Zobrazeno 1 - 10
of 69
pro vyhledávání: '"James J L Hodge"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158222 (2016)
Affect-induced cognitive judgement biases occur in both humans and animals. Animals in a more negative affective state tend to interpret ambiguous cues more negatively than animals in a more positive state and vice versa. Investigating animals' respo
Externí odkaz:
https://doaj.org/article/0c1d1e53a1894568b795931ccdf897ca
Autor:
Bilal eMalik, James J L Hodge
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Calcium (Ca2+) and Calmodulin (CaM)-dependent serine/threonine kinase II (CaMKII) plays a central role in synaptic plasticity and memory due to its ability to phosphorylate itself and regulate its own kinase activity. Autophosphorylation at threonine
Externí odkaz:
https://doaj.org/article/41a1f1d23d354c83bca9e6d16d9e159e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 6 (2013)
Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on a
Externí odkaz:
https://doaj.org/article/a35f6516027c4015b4a407271f6bcc76
Publikováno v:
Frontiers in Neural Circuits, Vol 7 (2013)
CaMKII is a central molecule in mechanisms of synaptic plasticity and memory. A vital feature of CaMKII in plasticity is its ability to switch to a calcium (Ca2+) independent constitutively active state after autophosphorylation at threonine 287 (T28
Externí odkaz:
https://doaj.org/article/59fb46426c8e4a96bd9fa578331d4fd4
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62445 (2013)
In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory
Externí odkaz:
https://doaj.org/article/1442a60120534175981982cfe0f069ed
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50279 (2012)
In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative me
Externí odkaz:
https://doaj.org/article/0c01fcc6412d4409ba113fd773e6ace2
Autor:
Sonia Cavaliere, James J L Hodge
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23898 (2011)
Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness. KCNQ2/3 channels form the native M-curre
Externí odkaz:
https://doaj.org/article/8f3e0681604f405ca0f8cf8ffd4e9502
Autor:
James J L Hodge
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 2 (2009)
Ion channels are the determinants of excitability; therefore, manipulation of their levels and properties provides an opportunity for the investigator to modulate neuronal and circuit function. There are a number of ways to suppress electrical activi
Externí odkaz:
https://doaj.org/article/6e99af35437b489daf7f4caf30b9dcc5
Publikováno v:
Clocks & Sleep, Vol 5, Iss 3, Pp 499-506 (2023)
Standardization plays a crucial role in ensuring the reliability, reproducibility, and interoperability of research data in the biomedical sciences. Metadata standards are one foundation for the FAIR (Findable, Accessible, Interoperable, and Reusable
Externí odkaz:
https://doaj.org/article/60a684a028224640a464538cffeb239e
Autor:
Amina Aboufares El Alaoui, Edgar Buhl, Sabrina Galizia, James J. L. Hodge, Luisa de Vivo, Michele Bellesi
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Prolonged cellular activity may overload cell function, leading to high rates of protein synthesis and accumulation of misfolded or unassembled proteins, which cause endoplasmic reticulum (ER) stress and activate the unfolded prot
Externí odkaz:
https://doaj.org/article/3e57547dfbcf4ac993fb19b4ab38e84b