Zobrazeno 1 - 10
of 105
pro vyhledávání: '"James J Kobie"'
Autor:
Michael S Piepenbrink, Jun-Gyu Park, Ashlesha Deshpande, Andreas Loos, Chengjin Ye, Madhubanti Basu, Sanghita Sarkar, Ahmed Magdy Khalil, David Chauvin, Jennifer Woo, Philip Lovalenti, Nathaniel B Erdmann, Paul A Goepfert, Vu L Truong, Richard A Bowen, Mark R Walter, Luis Martinez-Sobrido, James J Kobie
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010691 (2022)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the viru
Externí odkaz:
https://doaj.org/article/cdcf68c2004649efa158bcfc0b8de359
Autor:
Hong Zhu, Elizabeth Mathew, Sara M Connelly, Jeffrey Zuber, Mark Sullivan, Michael S Piepenbrink, James J Kobie, Mark E Dumont
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221550 (2019)
HIV envelope protein (Env) is the sole target of broadly neutralizing antibodies (BNAbs) that are capable of neutralizing diverse strains of HIV. While BNAbs develop spontaneously in a subset of HIV-infected patients, efforts to design an envelope pr
Externí odkaz:
https://doaj.org/article/d77aab13500143669e8882fa1284f23c
Autor:
Elizabeth Mathew, Hong Zhu, Sara M Connelly, Mark A Sullivan, Matthew G Brewer, Michael S Piepenbrink, James J Kobie, Stephen Dewhurst, Mark E Dumont
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205756 (2018)
As a step toward the development of variant forms of Env with enhanced immunogenic properties, we have expressed the glycoprotein in the yeast surface display system in a form that can be subjected to random mutagenesis followed by screening for form
Externí odkaz:
https://doaj.org/article/c0cf1fedace34778b6b72443b5a17aea
Autor:
Juan Pablo Jaworski, Peter Bryk, Zachary Brower, Bo Zheng, Ann J Hessell, Alexander F Rosenberg, Tong Tong Wu, Ignacio Sanz, Michael C Keefer, Nancy L Haigwood, James J Kobie
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172524 (2017)
Our central hypothesis is that protection against HIV infection will be powerfully influenced by the magnitude and quality of the B cell response. Although sterilizing immunity, mediated by pre-formed abundant and potent antibodies is the ultimate go
Externí odkaz:
https://doaj.org/article/156c2178b2e6495d8f1e8f9f33c0b041
Autor:
Michael S Piepenbrink, Memorie Samuel, Bo Zheng, Brittany Carter, Christopher Fucile, Catherine Bunce, Michelle Kiebala, Atif A Khan, Juilee Thakar, Sanjay B Maggirwar, Diane Morse, Alexander F Rosenberg, Norman J Haughey, William Valenti, Michael C Keefer, James J Kobie
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158641 (2016)
Injection drug use is a growing major public health concern. Injection drug users (IDUs) have a higher incidence of co-morbidities including HIV, Hepatitis, and other infections. An effective humoral response is critical for optimal homeostasis and p
Externí odkaz:
https://doaj.org/article/3df7b2ff0e9f4b809c0c9be0c9335168
Autor:
Michelle Kiebala, Meera V Singh, Michael S Piepenbrink, Xing Qiu, James J Kobie, Sanjay B Maggirwar
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130061 (2015)
Recent work has indicated that platelets, which are anucleate blood cells, significantly contribute to inflammatory disorders. Importantly, platelets also likely contribute to various inflammatory secondary disorders that are increasingly associated
Externí odkaz:
https://doaj.org/article/804e25646dab45c68cf5a43554a99490
Autor:
Tim R. Mosmann, Jonathan A. Rebhahn, Stephen C. De Rosa, Michael C. Keefer, M. Juliana McElrath, Nadine G. Rouphael, Giuseppe Pantaleo, Peter B. Gilbert, Lawrence Corey, James J. Kobie, Juilee Thakar
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe HVTN 105 vaccine clinical trial tested four combinations of two immunogens - the DNA vaccine DNA-HIV-PT123, and the protein vaccine AIDSVAX B/E. All combinations induced substantial antibody and CD4+ T cell responses in many participa
Externí odkaz:
https://doaj.org/article/52dd5afd41534ef9921ac84b943b0929
Autor:
Danielle C Alcéna, James J Kobie, Denise A Kaminski, Alexander F Rosenberg, Jonelle L Mattiacio, Matthew Brewer, Stephen Dewhurst, Carrie Dykes, Xia Jin, Michael C Keefer, Ignacio Sanz
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85098 (2013)
Potent HIV-1 specific broadly neutralizing antibodies (BNA) are uncommon in HIV infected individuals, and have proven hard to elicit by vaccination. Several, isolated monoclonal BNA are polyreactive and also recognize self-antigens, suggesting a brea
Externí odkaz:
https://doaj.org/article/edcffecc57734e67bebc81e134045933
Autor:
Daniel N. Streblow, Alec J. Hirsch, Jeffrey J. Stanton, Anne D. Lewis, Lois Colgin, Ann J. Hessell, Craig N. Kreklywich, Jessica L. Smith, William F. Sutton, David Chauvin, Jennifer Woo, Benjamin N. Bimber, Cierra N. LeBlanc, Sonia N. Acharya, Brian J. O’Roak, Harjinder Sardar, Mohammad M. Sajadi, Zahra R. Tehrani, Mark R. Walter, Luis Martinez-Sobrido, James J. Kobie, Rachel J. Reader, Katherine J. Olstad, Theodore R. Hobbs, Erica Ollmann Saphire, Sharon L. Schendel, Robert H. Carnahan, Jonas Knoch, Luis M. Branco, James E. Crowe, Koen K. A. Van Rompay, Phillip Lovalenti, Vu Truong, Donald N. Forthal, Nancy L. Haigwood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease in rhesus macaques inoculated with
Externí odkaz:
https://doaj.org/article/8766bd1dd34746b3b375ff5406037cd7
Autor:
James J Kobie, Danielle C Alcena, Bo Zheng, Peter Bryk, Jonelle L Mattiacio, Matthew Brewer, Celia Labranche, Faith M Young, Stephen Dewhurst, David C Montefiori, Alexander F Rosenberg, Changyong Feng, Xia Jin, Michael C Keefer, Ignacio Sanz
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35356 (2012)
The induction of a broadly neutralizing antibody (BNAb) response against HIV-1 would be a desirable feature of a protective vaccine. Vaccine strategies thus far have failed to elicit broadly neutralizing antibody responses; however a minority of HIV-
Externí odkaz:
https://doaj.org/article/18b57b77d009427dbc4266c3d36ce073