Zobrazeno 1 - 10
of 141
pro vyhledávání: '"James J Cox"'
Autor:
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114614- (2024)
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain
Externí odkaz:
https://doaj.org/article/cd2c68f5fde8412d87e766b66f097032
Autor:
Jennifer Koenig, Robert Werdehausen, John E Linley, Abdella M Habib, Jeffrey Vernon, Stephane Lolignier, Niels Eijkelkamp, Jing Zhao, Andrei L Okorokov, C Geoffrey Woods, John N Wood, James J Cox
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128830 (2015)
The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that regulate this gene are still incompletely understood. Here, we describe a novel natural
Externí odkaz:
https://doaj.org/article/8a1eee2c1c6e4b68bfb0e8d73bdc021d
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41750 (2012)
Genes encoding the α subunits of neuronal sodium channels have evolutionarily conserved sites of alternative splicing but no functional differences have been attributed to the splice variants. Here, using Na(V)1.7 as an exemplar, we show that the so
Externí odkaz:
https://doaj.org/article/53befd21fea34f689ca7fd9ad09d212d
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Hajar Mikaeili, Abdella M. Habib, Charlix Yeung, Sonia Santana-Varela, Ana P. Luiz, Kseniia Panteleeva, Sana Zuberi, Alkyoni Athanasiou-Fragkouli, Henry Houlden, John N. Wood, Andrei L. Okorokov, James J. Cox
Chronic pain affects millions of people worldwide. Studying pain insensitive individuals helps to identify novel analgesic strategies. Here we report how the recently discoveredFAAH-OUTlncRNA-encoding gene, which was found from studying a pain insens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6add5d7128622d82f1ba2c2edbf464c
https://doi.org/10.1101/2022.10.20.513066
https://doi.org/10.1101/2022.10.20.513066
Autor:
Annette Lischka, Petra Lassuthova, Arman Çakar, Christopher J. Record, Jonas Van Lent, Jonathan Baets, Maike F. Dohrn, Jan Senderek, Angelika Lampert, David L. Bennett, John N. Wood, Vincent Timmerman, Thorsten Hornemann, Michaela Auer-Grumbach, Yesim Parman, Christian A. Hübner, Miriam Elbracht, Katja Eggermann, C. Geoffrey Woods, James J. Cox, Mary M. Reilly, Ingo Kurth
Publikováno v:
Nature reviews disease primers
Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic neuropathy (HSAN). This heterogeneous group of disorders highlights the essenti
Publikováno v:
Medizinische Genetik. 32:233-241
Peripheral sensory neurons are afferent neurons that innervate the skin, joints, bones, muscles, and mucosal tissues. By converting different stimuli into action potentials, they transmit signals for the sensing of temperature, touch, pressure, or pa
Autor:
Jennifer R. Deuis, Lotten Ragnarsson, Samuel D. Robinson, Zoltan Dekan, Lerena Chan, Ai-Hua Jin, Poanna Tran, Kirsten L. McMahon, Shengnan Li, John N. Wood, James J. Cox, Glenn F. King, Volker Herzig, Irina Vetter
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2022)
Frontiers in Pharmacology, Vol 12 (2022)
Venoms from cone snails and arachnids are a rich source of peptide modulators of voltage-gated sodium (NaV) channels, however relatively few venom-derived peptides with activity at the mammalian NaV1.8 subtype have been isolated. Here, we describe th
Autor:
Tabea, Klasfauseweh, Mathilde R, Israel, Lotten, Ragnarsson, James J, Cox, Thomas, Durek, David A, Carter, Andreas, Leffler, Irina, Vetter, Jennifer R, Deuis
Publikováno v:
European journal of pharmacology. 925
QX-314 is a quaternary permanently charged lidocaine derivative that inhibits voltage-gated sodium channels (Na
Autor:
Tabea Klasfauseweh, Mathilde R. Israel, Lotten Ragnarsson, James J. Cox, Thomas Durek, David A. Carter, Andreas Leffler, Irina Vetter, Jennifer R. Deuis
Publikováno v:
European Journal of Pharmacology. 925:175013