Zobrazeno 1 - 10
of 58
pro vyhledávání: '"James J Burston"'
Autor:
Peter R W Gowler, Paul I Mapp, James J Burston, Mohsen Shahtaheri, David A Walsh, Victoria Chapman
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur
Externí odkaz:
https://doaj.org/article/8d13051dad184535946f9d1a321775e3
Autor:
James J Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, Jenna M Turner, Gareth J Hathway, Andrew J Bennett, David A Walsh, David A Kendall, Aron Lichtman, Victoria Chapman
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80440 (2013)
Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impact
Externí odkaz:
https://doaj.org/article/1f09b3967b034c029341bbbc8f278674
Autor:
Peter R W Gowler, Stephen G. Woodhams, Victoria Chapman, Amanda Lillywhite, Sara Vieira Gonçalves, Gareth J. Hathway, Li Li, David Watson, David A. Walsh, Meritxell Canals, James J. Burston
Publikováno v:
Pain Reports
PAIN Reports, Vol 6, Iss 4, p e956 (2021)
PAIN Reports, Vol 6, Iss 4, p e956 (2021)
Supplemental Digital Content is Available in the Text. Comorbid anxiety and osteoarthritis pain is associated with increased opioid intake. Our translational model identifies reduced opioid analgesia and endogenous opioid dysfunction as potential mec
Autor:
Gareth Hathway, David A. Walsh, Amanda Lillywhite, Li Li, Meritxell Canals, Stephen George Woodhams, David Watson, James J. Burston, Victoria Chapman, Peter R W Gowler
Chronic pain states such as osteoarthritis (OA) are often associated with negative affect, including anxiety and depression. This is, in turn, associated with greater opioid analgesic use, potentially contributing to current and future opioid crises.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dbbf51df6534c80ee9d314702561cd
https://doi.org/10.1101/2020.04.24.057570
https://doi.org/10.1101/2020.04.24.057570
Autor:
Victoria Chapman, Petros Pousinis, Catherine A. Ortori, Dave Barrett, James J. Burston, Peter R W Gowler
Publikováno v:
Metabolomics
Introduction Osteoarthritis (OA) is the most common form of joint disease, causing pain and disability. Previous studies have demonstrated the role of lipid mediators in OA pathogenesis. Objectives To explore potential alterations in the plasma lipid
Autor:
Ian M. Devonshire, Victoria Chapman, Luting Xu, Malcolm Prior, Sarina J. Iwabuchi, D. J. G. Watson, Charles M. Greenspon, Dorothee P. Auer, James J. Burston, Amanda Lillywhite
Publikováno v:
NeuroImage, Vol 157, Iss, Pp 500-510 (2017)
Neuroimage
Neuroimage
Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant sp
Autor:
Alasdair G. Kay, Alicia J. El Haj, Luting Xu, Hareklea Markides, Paul I. Mapp, Robert H. Morris, Oksana Kehoe, Devi Rani Sagar, James J. Burston, Victoria Chapman
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Stem Cells International
Stem Cells International
Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi
Autor:
Lilian N. Nwosu, Peter R.W. Gowler, James J. Burston, Biljana Rizoska, Karin Tunblad, Erik Lindström, Urszula Grabowska, Li Li, Dan F. McWilliams, David A. Walsh, Victoria Chapman
Publikováno v:
PAIN Reports, Vol 3, Iss 6, p e685 (2018)
Introduction:. The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of cathepsin K, on pain behaviour and joint pathology in a model
Autor:
Micah J. Niphakis, Victoria Chapman, David A. Barrett, Sarir Sarmad, James J. Burston, Paul I. Mapp, David A. Walsh, Benjamin F. Cravatt
Publikováno v:
British Journal of Pharmacology. 173:3134-3144
Background and purpose: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-rel
Autor:
David A. Walsh, Paul I. Mapp, Victoria Chapman, Mohsen Shahtaheri, James J. Burston, Peter R W Gowler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur