Zobrazeno 1 - 10
of 161
pro vyhledávání: '"James J, Moresco"'
Autor:
Xue Zhong, Nagesh Peddada, Jianhui Wang, James J. Moresco, Xiaowei Zhan, John M. Shelton, Jeffrey A. SoRelle, Katie Keller, Danielle Renee Lazaro, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Distinct pathways and molecules may support embryonic versus postnatal thymic epithelial cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC numbers and function are maintained postnatally. A viable missense al
Externí odkaz:
https://doaj.org/article/9bb9af5e62a640e19549ec5330ca64ad
Autor:
Ran Song, William McAlpine, Aaron M. Fond, Evan Nair-Gill, Jin Huk Choi, Elisabeth E. L. Nyström, Liisa Arike, Sydney Field, Xiaohong Li, Jeffrey A. SoRelle, James J. Moresco, Eva Marie Y. Moresco, John R. Yates, Parastoo Azadi, Josephine Ni, George M. H. Birchenough, Bruce Beutler, Emre E. Turer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. Using a forward genetic screen, we have fou
Externí odkaz:
https://doaj.org/article/c2c5a71364e54a7780fc6c6274ed1f2e
Autor:
Thu-Thuy Nguyen, Tae Heung Kim, Emily Bencosme-Cuevas, Jacquie Berry, Alex Samuel Kiarie Gaithuma, Moiz Ashraf Ansari, Tae Kwon Kim, Lucas Tirloni, Zeljko Radulovic, James J Moresco, John R Yates, Albert Mulenga
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1012032 (2024)
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human vector borne diseases for which there is no effective prevention method. Identification of tick saliva transmission factors of the LD agent is needed before the highly
Externí odkaz:
https://doaj.org/article/6061833a4c23447c8ecc79d6e1361558
Autor:
Albert Mulenga, Zeljko Radulovic, Lindsay Porter, Taylor Hollman Britten, Tae Kwon Kim, Lucas Tirloni, Alex Kiarie Gaithuma, Grace O. Adeniyi-Ipadeola, Jolene K. Dietrich, James J. Moresco, John R. Yates
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Ixodes scapularis long-term blood feeding behavior is facilitated by a tick secreted bio adhesive (tick cement) that attaches tick mouthparts to skin tissue and prevents the host from dislodging the attached tick. Understanding tick cement f
Externí odkaz:
https://doaj.org/article/b72626fb78f0460ebeeb45641900ac34
Autor:
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor
Externí odkaz:
https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6
Autor:
Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010710 (2023)
Prader-Willi syndrome (PWS) is a multisystem disorder with neurobehavioral, metabolic, and hormonal phenotypes, caused by loss of expression of a paternally-expressed imprinted gene cluster. Prior evidence from a PWS mouse model identified abnormal p
Externí odkaz:
https://doaj.org/article/511e07a3ded143c49933e62d23762e4c
Autor:
Kristina Seiler, Magali Humbert, Petra Minder, Iris Mashimo, Anna M. Schläfli, Deborah Krauer, Elena A. Federzoni, Bich Vu, James J. Moresco, John R. Yates, Martin C. Sadowski, Ramin Radpour, Thomas Kaufmann, Jean-Emmanuel Sarry, Joern Dengjel, Mario P. Tschan, Bruce E. Torbett
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-14 (2022)
Abstract The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously expressed, the less well-studied HK3 is primarily expressed in he
Externí odkaz:
https://doaj.org/article/0483ca7b4b974a9db20fe6d5d5f9e6fc
Autor:
Yang S Chen, Wanfu Hou, Sharon Tracy, Alex T Harvey, Vince Harjono, Fan Xu, James J Moresco, John R Yates III, Brian M Zid
Publikováno v:
eLife, Vol 11 (2022)
During times of unpredictable stress, organisms must adapt their gene expression to maximize survival. Along with changes in transcription, one conserved means of gene regulation during conditions that quickly repress translation is the formation of
Externí odkaz:
https://doaj.org/article/9a40172625d64ca686f4f4c4e251ccc3
Autor:
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Juan Carlos Izpisua Belmonte, Mo Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/fe63d9b64eec47f49dc6e724eaff5a8b
Autor:
Jordan E. Burke, Adam D. Longhurst, Prashanthi Natarajan, Beiduo Rao, John Liu, Jade Sales-Lee, Yasaman Mortensen, James J. Moresco, Jolene K. Diedrich, John R. Yates, Hiten D. Madhani
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2235-2244 (2019)
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dc
Externí odkaz:
https://doaj.org/article/7f7f371b930043a1aae902382619436c