Zobrazeno 1 - 10
of 395
pro vyhledávání: '"James J, Moon"'
Autor:
Laura Bricio-Moreno, Juliana Barreto de Albuquerque, Jake M. Neary, Thao Nguyen, Lucy F. Kuhn, YeePui Yeung, Kathryn M. Hastie, Sara Landeras-Bueno, Eduardo Olmedillas, Chitra Hariharan, Anusha Nathan, Matthew A. Getz, Alton C. Gayton, Ashok Khatri, Gaurav D. Gaiha, Erica Ollmann Saphire, Andrew D. Luster, James J. Moon
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Understanding adaptive immunity against SARS-CoV-2 is a major requisite for the development of effective vaccines and treatments for COVID-19. CD4+ T cells play an integral role in this process primarily by generating antiviral cytokines and providin
Externí odkaz:
https://doaj.org/article/c24e9f2a0035458781607e8fc3058230
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Despite significant advances in immune checkpoint blockade (ICB), immunosuppression mediated by tumor-associated myeloid cells (TAMCs) poses a major barrier to cancer immunotherapy. In addition, while immunogenic cell death (ICD) provides a
Externí odkaz:
https://doaj.org/article/bdd41061df664c3ba88533a3b50f245e
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/12db372f3f1a4d94803ae76580601a4b
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2ac6a4517a0a4621914573ed3263505a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/075a3dc42ac34f8188e90af3fc569470
Autor:
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila L. Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham, Alan G. Barbour, Catherine E. Costello, James J. Moon, Allen C. Steere
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
BACKGROUND Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthrit
Externí odkaz:
https://doaj.org/article/a775241c4c164c029eb30c87de7b5e80
Autor:
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112839- (2023)
Summary: Self-antigen-specific T cells are prevalent in the mature adaptive immune system but are regulated through multiple mechanisms of tolerance. However, inflammatory conditions such as tissue injury may allow these T cells to break tolerance an
Externí odkaz:
https://doaj.org/article/789163fd0bd44ba380335678039c2022
Autor:
John S. Schardt, Ghasidit Pornnoppadol, Alec A. Desai, Kyung Soo Park, Jennifer M. Zupancic, Emily K. Makowski, Matthew D. Smith, Hongwei Chen, Mayara Garcia de Mattos Barbosa, Marilia Cascalho, Thomas M. Lanigan, James J. Moon, Peter M. Tessier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Monoclonal antibodies that target SARS-CoV-2 with high affinity are valuable for a wide range of biomedical applications involving novel coronavirus disease (COVID-19) diagnosis, treatment, and prophylactic intervention. Strategies for the r
Externí odkaz:
https://doaj.org/article/75354dc4a1d54b489cf8d0e0fd26f7ef
IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses
Autor:
Daniel F. Camacho, Tania E. Velez, Maile K. Hollinger, Esther Wang, Chanie L. Howard, Eli P. Darnell, Domenick E. Kennedy, Paulette A. Krishack, Cara L. Hrusch, Marcus R. Clark, James J. Moon, Anne I. Sperling
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory aller
Externí odkaz:
https://doaj.org/article/7651a0c359e14735b6b32d72add5e4f5
Autor:
Marie-Ève Lebel, Marie Coutelier, Maria Galipeau, Claudia L. Kleinman, James J. Moon, Heather J. Melichar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyse
Externí odkaz:
https://doaj.org/article/d95861ab2e314e62a5e742bbc1326592