Zobrazeno 1 - 10
of 241
pro vyhledávání: '"James J, Bull"'
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 294-302 (2024)
Introduction Transmissible vaccines offer a novel approach to suppressing viruses in wildlife populations, with possible applications against viruses that infect humans as zoonoses – Lassa, Ebola, rabies. To ensure safety, current designs propose a
Externí odkaz:
https://doaj.org/article/075be305be1f4726bacb274ec1c03dc7
Publikováno v:
Cells, Vol 13, Iss 7, p 585 (2024)
Recombination among different phages sometimes facilitates their ability to grow on new hosts. Protocols to direct the evolution of phage host range, as might be used in the application of phage therapy, would then benefit from including steps to ena
Externí odkaz:
https://doaj.org/article/a0271e3f8b964e79abf59746515a637a
Publikováno v:
Evolutionary Applications, Vol 15, Iss 5, Pp 721-734 (2022)
Abstract Gene drives can potentially be used to suppress pest populations, and the advent of CRISPR technology has made it feasible to engineer them in many species, especially insects. What remains largely unknown for implementations is whether anti
Externí odkaz:
https://doaj.org/article/6b533199bcfe4d418a74681b8a290584
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010131 (2022)
The concept of a nucleic acid barcode applied to pathogen genomes is easy to grasp and the many possible uses are straightforward. But implementation may not be easy, especially when growing through multiple generations or assaying the pathogen long-
Externí odkaz:
https://doaj.org/article/88da24c921c6478eb075bffe73a67fe1
Autor:
Nathan C. Layman, Beth M. Tuschhoff, Andrew J. Basinski, Christopher H. Remien, James J. Bull, Scott L. Nuismer
Publikováno v:
Evolutionary Applications, Vol 14, Iss 2, Pp 348-359 (2021)
Abstract Genetically engineered organisms are prone to evolve in response to the engineering. This evolution is often undesirable and can negatively affect the purpose of the engineering. Methods that maintain the stability of engineered genomes are
Externí odkaz:
https://doaj.org/article/59eff813c01244cba7c1e7da5042072b
Autor:
James J. Bull, Richard Gomulkiewicz
Publikováno v:
PeerJ, Vol 10, p e13301 (2022)
Background The sterile insect technique (SIT) has been used to suppress and even extinguish pest insect populations. The method involves releasing artificially reared insects (usually males) that, when mating with wild individuals, sterilize the broo
Externí odkaz:
https://doaj.org/article/f1d9b6404a8e4b4783bb9efa7f0423b6
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 293 (2023)
Commercially available cellulases and amylases can disperse the pathogenic bacteria embedded in biofilms. This suggests that polysaccharide-degrading enzymes would be useful as antibacterial therapies to aid the treatment of biofilm-associated bacter
Externí odkaz:
https://doaj.org/article/47a2b52ec09f488c82020b3f60c935eb
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1709 (2022)
Background: The host ranges of individual phages tend to be narrow, yet many applications of phages would benefit from expanded host ranges. Empirical methods have been developed to direct the evolution of phages to attack new strains, but the method
Externí odkaz:
https://doaj.org/article/8bd0abbec73040078adf6e5a3341c137
Publikováno v:
Evolutionary Applications, Vol 12, Iss 8, Pp 1595-1609 (2019)
Abstract Transmissible vaccines offer a revolutionary approach for controlling infectious disease and may provide one of the few feasible methods for eliminating pathogens from inaccessible wildlife populations. Current efforts to develop transmissib
Externí odkaz:
https://doaj.org/article/40da1da2943e40ce85e8ee8626d59b4d
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008602 (2021)
Many viral infections can be prevented by immunizing with live, attenuated vaccines. Early methods of attenuation were hit-and-miss, now much improved by genetic engineering. However, even current methods operate on the principle of genetic harm, red
Externí odkaz:
https://doaj.org/article/013df5f259b94c5eabacef3fbb13b16e