Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James I.S. MacDonald"'
Publikováno v:
Journal of Biological Chemistry. 280:19461-19471
The human tumorous imaginal disc 1 (TID1) proteins including TID1(L) and TID1(S), members of the DnaJ domain protein family, are involved in multiple intracellular signaling pathways such as apoptosis induction, cell proliferation, and survival. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a34ab350a1aedeea068566edb34effe
https://doi.org/10.1074/jbc.m500313200
https://doi.org/10.1074/jbc.m500313200
Publikováno v:
Journal of Neurochemistry. 69:954-967
To investigate potential differences between the family of Trk receptors that might have differential consequences on cell signaling, we generated a rat TrkA homologue of the 14-amino acid kinase insert isoform of TrkC termed TrkAKi. Signal transduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fd3d2694a17b6a6c1c57ec47b993df
https://doi.org/10.1046/j.1471-4159.1997.69030954.x
https://doi.org/10.1046/j.1471-4159.1997.69030954.x
Publikováno v:
Journal of Biological Chemistry. 274:9861-9870
We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5fb94c2460119695eda3be35c72e0c
https://doi.org/10.1074/jbc.274.14.9861
https://doi.org/10.1074/jbc.274.14.9861
Publikováno v:
Journal of Biological Chemistry. 270:354-360
CTP:phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells. CT is found in both soluble and particulate forms, both of which are nuclear. We report here the identification of a 21-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c38a345f9f517b9ef657d2f2d9e7eca
https://doi.org/10.1074/jbc.270.1.354
https://doi.org/10.1074/jbc.270.1.354
Publikováno v:
Robarts Molecular Brain Publications
Ectopic expression of the TrkA receptor tyrosine kinase in tumors of the nervous system can mediate nerve growth factor (NGF)-dependent cell death by apoptosis and /or autophagy. Herein, we demonstrate that TrkA can also induce cell death in medullob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45ec1dd15ca7dd482544784865817c8
https://ir.lib.uwo.ca/mbrainpub/3
https://ir.lib.uwo.ca/mbrainpub/3
Autor:
Renée Phillips, Susan O. Meakin, Todd Hryciw, James I.S. MacDonald, Stephen H. Pasternak, Claudia Seah
Publikováno v:
Robarts Molecular Brain Publications
J. Neurochem. (2009) 112, 924–939. Abstract Fibroblast growth factor (FGF) mediated signaling is essential to many aspects of neural development. Activated FGF receptors signal primarily through the FGF receptor substrate (Frs) adapters, which incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39930872e646735638d90eee7c5a59f5
https://ir.lib.uwo.ca/mbrainpub/4
https://ir.lib.uwo.ca/mbrainpub/4
Publikováno v:
Biochimica et biophysica acta. 1763(4)
We have investigated the signaling properties of the fibroblast growth factor (FGF) receptor substrate 3 (FRS3), also known as SNT-2 or FRS2β, in neurotrophin-dependent differentiation in comparison with the related adapter FRS2 (SNT1 or FRS2α). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af16554fb537ed65e7d1abb833b90cb
https://pubmed.ncbi.nlm.nih.gov/16697063
https://pubmed.ncbi.nlm.nih.gov/16697063
Publikováno v:
The Journal of biological chemistry. 280(1)
Ras guanine-releasing factor 1 (RasGrf1), a guanine nucleotide exchange factor for members of the Ras and Rho family of GTPases, is highly expressed in the brain. It is regulated by two separate mechanisms, calcium regulation through interaction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d2e6417866f982e28fae51fe6c0433
https://pubmed.ncbi.nlm.nih.gov/15513915
https://pubmed.ncbi.nlm.nih.gov/15513915
Publikováno v:
The Journal of Cell Biology
We provide the first characterization of a novel signaling adapter, Nesca, in neurotrophic signal transduction. Nesca contains a RUN domain, a WW domain, a leucine zipper, a carboxyl-terminal SH3 domain, and several proline-rich regions. Nesca is hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc8c514d877bf65ec7ef9c3c4dbb3f6
https://pubmed.ncbi.nlm.nih.gov/15024033
https://pubmed.ncbi.nlm.nih.gov/15024033
Autor:
James I.S. MacDonald, Lynne C. Weaver, Daniel R. Marsh, Eilis F. Hamilton, Sharon T. Wong, Susan O. Meakin
Publikováno v:
Journal of neurotrauma. 19(12)
Increased intraspinal nerve growth factor (NGF) after spinal cord injury (SCI) is detrimental to the autonomic nervous system. Autonomic dysreflexia is a debilitating condition characterized by episodic hypertension, intense headache, and sweating. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9463789b4ccce607ec8b12e1e865d4c
https://pubmed.ncbi.nlm.nih.gov/12542855
https://pubmed.ncbi.nlm.nih.gov/12542855