Zobrazeno 1 - 10
of 473
pro vyhledávání: '"James I. Mullins"'
Autor:
Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The Antibody Mediated Prevention (AMP) trials (NCT02716675 and NCT02568215) demonstrated that passive administration of the broadly neutralizing monoclonal antibody VRC01 could prevent some HIV-1 acquisition events. Here, we use mathematical
Externí odkaz:
https://doaj.org/article/794805ba580c4e44895b377fd359c2eb
Autor:
Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/ef191c52261c47488786020343882bd3
Autor:
Daisy Ko, Sherry McLaughlin, Wenjie Deng, James I. Mullins, Joan Dragavon, Socorro Harb, Robert W. Coombs, Lisa M. Frenkel
Publikováno v:
Viruses, Vol 16, Iss 4, p 510 (2024)
HIV-1 typically infects cells via the CD4 receptor and CCR5 or CXCR4 co-receptors. Maraviroc is a CCR5-specific viral entry inhibitor; knowledge of viral co-receptor specificity is important prior to usage. We developed and validated an economical V3
Externí odkaz:
https://doaj.org/article/f23c85245d7049c8b39453509c2488f3
Autor:
Kelly E. Seaton, Yunda Huang, Shelly Karuna, Jack R. Heptinstall, Caroline Brackett, Kelvin Chiong, Lily Zhang, Nicole L. Yates, Mark Sampson, Erika Rudnicki, Michal Juraska, Allan C. deCamp, Paul T. Edlefsen, James I. Mullins, Carolyn Williamson, Raabya Rossenkhan, Elena E. Giorgi, Avi Kenny, Heather Angier, April Randhawa, Joshua A. Weiner, Michelle Rojas, Marcella Sarzotti-Kelsoe, Lu Zhang, Sheetal Sawant, Margaret E. Ackerman, Adrian B. McDermott, John R. Mascola, John Hural, M. Julianna McElrath, Philip Andrew, Jose A. Hidalgo, Jesse Clark, Fatima Laher, Catherine Orrell, Ian Frank, Pedro Gonzales, Srilatha Edupuganti, Nyaradzo Mgodi, Lawrence Corey, Lynn Morris, David Montefiori, Myron S. Cohen, Peter B. Gilbert, Georgia D. Tomaras
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104590- (2023)
Summary: Background: The phase 2b proof-of-concept Antibody Mediated Prevention (AMP) trials showed that VRC01, an anti-HIV-1 broadly neutralising antibody (bnAb), prevented acquisition of HIV-1 sensitive to VRC01. To inform future study design and d
Externí odkaz:
https://doaj.org/article/1fb6811de76c4d6b9e00985ef3384be8
Autor:
Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, James I. Mullins, Hans-Peter Kiem, Deborah Heydenburg Fuller, Christopher W. Peterson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which facilitates viral escap
Externí odkaz:
https://doaj.org/article/23b8184a8d714211a8e14e49ff22762b
Autor:
Basiel Cole, Laurens Lambrechts, Pierre Gantner, Ytse Noppe, Noah Bonine, Wojciech Witkowski, Lennie Chen, Sarah Palmer, James I. Mullins, Nicolas Chomont, Marion Pardons, Linos Vandekerckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir ma
Externí odkaz:
https://doaj.org/article/bb2639ad014b4e8797620272ce98b655
Autor:
Antonio Valentin, Cristina Bergamaschi, Margherita Rosati, Matthew Angel, Robert Burns, Mahesh Agarwal, Janina Gergen, Benjamin Petsch, Lidia Oostvogels, Edde Loeliger, Kara W. Chew, Steven G. Deeks, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens develop
Externí odkaz:
https://doaj.org/article/b7a5928e7818420ea6f7a20ebbe0d915
Autor:
Jessica E. Long, Diana M. Tordoff, Sari L. Reisner, Sayan Dasgupta, Kenneth H. Mayer, James I. Mullins, Javier R. Lama, Joshua T. Herbeck, Ann Duerr
Publikováno v:
The Lancet Regional Health. Americas, Vol 6, Iss , Pp 100121- (2022)
Summary: Background: Transgender women (TW) in Peru are disproportionately affected by HIV. The role that cisgender men who have sex with TW (MSTW) and their sexual networks play in TW's risk of acquiring HIV is not well understood. We used HIV seque
Externí odkaz:
https://doaj.org/article/0378a64952ee4e9d9d5baa07a00ea65b
Autor:
Laura E. Richert-Spuhler, Corinne M. Mar, Paurvi Shinde, Feinan Wu, Ting Hong, Evan Greene, Sharon Hou, Katherine Thomas, Raphael Gottardo, Nelly Mugo, Guy de Bruyn, Connie Celum, Jared M. Baeten, Jairam R. Lingappa, Jennifer M. Lund, Anna Wald, Mary S. Campbell, Lawrence Corey, Robert W. Coombs, James P. Hughes, Amalia Magaret, M. Juliana McElrath, Rhoda Morrow, James I. Mullins, David Coetzee, Kenneth Fife, Edwin Were, Max Essex, Joseph Makhema, Elly Katabira, Allan Ronald, Elizabeth Bukusi, Craig Cohen, Saidi Kapiga, Rachel Manongi, Carey Farquhar, Grace John-Stewart, James Kiarie, Sinead Delany-Moretlwe, Helen Rees, Glenda Gray, James McIntyre, Nelly Rwamba Mugo, Deborah Donnell, Lisa Frenkel, Craig W. Hendrix, Elioda Tumwesigye, Patrick Ndase, Eliabeth Bukusi, Jonathan Wangisi, James Campbell, Jordan Tappero
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100322- (2021)
Summary: We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to modify inflammatory responses. Using blood samples from individuals with and with
Externí odkaz:
https://doaj.org/article/77c9c8a5edec4baab70c11a3ba3a103b
Autor:
Xintao Hu, Zhongyan Lu, Antonio Valentin, Margherita Rosati, Kate E. Broderick, Niranjan Y. Sardesai, Preston A. Marx, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 9, Pp 2163-2177 (2018)
HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p
Externí odkaz:
https://doaj.org/article/345e21d02e5f4da798a547d65a96ab6f