Výsledky vyhledávání - "James I. K. Last"

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells

Autor: Amanda Dutton, Ciaran B. Woodman, Marilyn B. Chukwuma, James I. K. Last, Wenbin Wei, Martina Vockerodt, Karl R. N. Baumforth, Joanne R. Flavell, Martin Rowe, A. Malcolm R. Taylor, Lawrence S. Young, Paul G. Murray

Publikováno v: Blood. 109:2597-2603

Polycomb group (PcG) proteins are chromatin modifiers that are necessary for the maintenance and renewal of embryonic and adult stem cells. However, overexpression of the PcG protein, Bmi-1, causes lymphoma in transgenic mice. We show that Bmi-1 is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e6a0775c02c5f5ba97cbb028c4f08
https://doi.org/10.1182/blood-2006-05-020545

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Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity

Autor: Ian J. Sutton, James I. K. Last, Susan J. Ritchie, Hugh J. Harrington, Philip J. Byrd, A. Malcolm R. Taylor

Publikováno v: Annals of Neurology. 55:891-895

Ataxia telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder that arises because of mutations in the ATM gene. The 5762ins137 A→G point mutation activates a cryptic splice donor site resulting in a 137bp intronic insert being ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8332252c9dac782573ed9f00711ad8
https://doi.org/10.1002/ana.20139

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