Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James I. Griffin"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 89 (2021)
Despite the availability of molecularly targeted treatments such as antibodies and small molecules for human epidermal growth factor receptor 2 (HER2), hormone receptor (HR), and programmed death-ligand 1 (PD-L1), limited treatment options are availa
Externí odkaz:
https://doaj.org/article/8c29b1dad6914e5893c0a991bad61a30
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0300723 (2024)
Preclinical models of cancer are vital for assessing and predicting efficacies and toxicities of novel treatments prior to testing in human subjects. Current pancreatic tumor models exhibit variable growth rates, unpredictable tumor size after implan
Externí odkaz:
https://doaj.org/article/4e5da4f7c1f3486faa1b72bb112bddf3
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228557 (2020)
Early diagnosis along with new drugs targeted to cancer receptors and immunocheckpoints have improved breast cancer survival. However, full remission remains elusive for metastatic breast cancer due to dose-limiting toxicities of heavily used, highly
Externí odkaz:
https://doaj.org/article/cb89d7d76ccd4535a410f364e5bbf9bc
Autor:
Linxi Zhu, Jesse Yu, Lisa A. McConnachie, Qingxin Mu, Danny D. Shen, James I. Griffin, Simone Perazzolo, Rodney J. Y. Ho
Publikováno v:
Pharm Res
PURPOSE: To develop drug-combination nanoparticles (DcNPs) composed of hydrophilic gemcitabine (G) and hydrophobic paclitaxel (T) and deliver both drugs to metastatic cancer cells. METHODS: GT DcNPs were evaluated based on particle size and drug asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6aecfa50968a1232734efd62d0373
https://pubmed.ncbi.nlm.nih.gov/32968837
https://pubmed.ncbi.nlm.nih.gov/32968837
Autor:
Weston J. Smith, Vivian P. Vu, James I. Griffin, Lizanne G. Nilewski, Jessica F. Jones, Huy Tran, Dmitri Simberg, Nathan C. Gianneschi
Publikováno v:
Biomaterials. 161:57-68
Decoration of cell membranes with biomolecules, targeting ligands and imaging agents is an emerging strategy to improve functionality of cell-based therapies. Compared to covalent (e.g., click) chemistry or genetic expression on the cell surface, lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9492eaba4253ef74fd0354781eada15b
https://doi.org/10.1016/j.biomaterials.2018.01.029
https://doi.org/10.1016/j.biomaterials.2018.01.029
Autor:
Seyed Moein Moghimi, Donald S. Backos, Nirmal K. Banda, Guankui Wang, V. Michael Holers, Lin-Ping Wu, Dmitri Simberg, Barbara Brenneman, James I. Griffin, Fangfang Chen
Publikováno v:
Nature Nanotechnology. 12:387-393
When nanoparticles are intravenously injected into the body, complement proteins deposit on the surface of nanoparticles in a process called opsonization. These proteins prime the particle for removal by immune cells and may contribute toward infusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24471765e4177e425bc0eda961a995f0
https://doi.org/10.1038/nnano.2016.269
https://doi.org/10.1038/nnano.2016.269
Autor:
Dmitri Simberg, Guankui Wang, Radu Moldovan, Vivian P. Vu, Robert I. Scheinman, Weston J. Smith, Seyed Moein Moghimi, James I. Griffin, Dominik Stitch
Publikováno v:
ACS nano. 11(11)
Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynamics of non-PEGylated and PEGylated liposomes after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97a9b914a0b4d34739c43bbb511316a
https://pubmed.ncbi.nlm.nih.gov/29045127
https://pubmed.ncbi.nlm.nih.gov/29045127
Autor:
Dmitri Simberg, Siu Kit Kevin Cheng, Devatha P. Nair, Tomoko Hayashi, Dennis A. Carson, Manju Saraswathy, James I. Griffin
The bladder presents an attractive target for topical drug delivery. The barrier function of the bladder mucosa (urothelium) presents a penetration challenge for small molecules and nanoparticles. We found that focal mechanical injury of the urotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1caba37eef6f4a31566bbd5f7709931
https://europepmc.org/articles/PMC5618708/
https://europepmc.org/articles/PMC5618708/
Autor:
James I. Griffin, V. Michael Holers, Dmitri Simberg, Nirmal K. Banda, Seyed Moein Moghimi, Guankui Wang, Swetha Inturi, Barbara Brenneman
Publikováno v:
Frontiers in immunology, 2017, Vol.8, pp.151 [Peer Reviewed Journal]
Frontiers in Immunology
Frontiers in Immunology
Balancing surface functionalization and low immune recognition of nanomedicines is a major challenge. Opsonization with the third component of the complement protein (C3) plays a major role in immune cell recognition of nanomedicines. We used dextran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01191fe971284d22cb1d23ff5dbdfe3
Systemically injected drug delivery systems distribute into various organs and tissues, including liver, spleen and kidneys. Recent reports pointed out a significant accumulation of systemically injected nanoparticles in the skin. Skin constitutes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd022037c01779c0c85cad8f9311112e
https://europepmc.org/articles/PMC5617645/
https://europepmc.org/articles/PMC5617645/