Zobrazeno 1 - 10
of 24
pro vyhledávání: '"James I, MacDonald"'
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
Andrew Ward, Darren Yang, Wesley P. Wong, Serkan Cabi, Elisha Krieg, Bhavik Nathwani, Prakash Shrestha, Yi Luo, Toma E. Tomov, William M. Shih, James I. MacDonald, Hans T. Bergal, Alexander Johnson-Buck
Publikováno v:
Nature Nanotechnology. 16:1362-1370
Decoding the identity of biomolecules from trace samples is a longstanding goal in the field of biotechnology. Advances in DNA analysis have substantially affected clinical practice and basic research, but corresponding developments for proteins face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726d7e5e758032a33e31cc8662ea38e0
https://doi.org/10.1038/s41565-021-00979-0
https://doi.org/10.1038/s41565-021-00979-0
Publikováno v:
Paediatrics Publications
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The retinoblastoma tumour suppressor protein (RB) plays an important role in biological processes such as cell cycle control, DNA damage repair, epigenetic regulation, and genome stability. The canonical model of RB regulation is that cyclin-CDKs pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9be0b63c79d03d1f4bc3942d5d930d0
https://ir.lib.uwo.ca/paedpub/1152
https://ir.lib.uwo.ca/paedpub/1152
SUMMARYGenome-wide CRISPR screens are an effective discovery tool for genes that underlie diverse cellular mechanisms that can be scored through cell fitness. Loss-of-function screens are particularly challenging compared to gain-of-function because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbe66325a0c930d8eefde76265851e75
https://doi.org/10.1101/2020.06.04.134841
https://doi.org/10.1101/2020.06.04.134841
Autor:
Prakash, Shrestha, Darren, Yang, Toma E, Tomov, James I, MacDonald, Andrew, Ward, Hans T, Bergal, Elisha, Krieg, Serkan, Cabi, Yi, Luo, Bhavik, Nathwani, Alexander, Johnson-Buck, William M, Shih, Wesley P, Wong
Publikováno v:
Nature nanotechnology. 16(12)
Decoding the identity of biomolecules from trace samples is a longstanding goal in the field of biotechnology. Advances in DNA analysis have substantially affected clinical practice and basic research, but corresponding developments for proteins face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cced109efbc98b7858e4295730d4e1d
https://pubmed.ncbi.nlm.nih.gov/34675411
https://pubmed.ncbi.nlm.nih.gov/34675411
Autor:
Asghar Talebian, Susan O. Meakin, James I. MacDonald, Jennifer Leuenberger, Stephen H. Pasternak, Claudia Seah, Chunhui Li, Stephen W. Michnick
Publikováno v:
Paediatrics Publications
Macropinocytosis is a normal cellular process by which cells internalize extracellular fluids and nutrients from their environment and is one strategy that Ras-transformed pancreatic cancer cells use to increase uptake of amino acids to meet the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b32b689878fb97efa50f2d2ae93887
https://doi.org/10.1128/mcb.00255-16
https://doi.org/10.1128/mcb.00255-16
Publikováno v:
Angewandte Chemie. 128:8727-8731
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52729a4de21389a2ea7e48a188876cd
https://doi.org/10.1002/ange.201602353
https://doi.org/10.1002/ange.201602353
Autor:
Kareem M. El Muslemany, James I. MacDonald, Ioana L. Aanei, Adel M. ElSohly, Matthew B. Francis, Nina B. Hentzen
Publikováno v:
Journal of the American Chemical Society. 139(10)
The synthesis of complex protein-based bioconjugates has been facilitated greatly by recent developments in chemoselective methods for biomolecular modification. The oxidative coupling of o-aminophenols or catechols with aniline functional groups is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21c3340a2ba4fbee5d0f82f1e952df8
https://pubmed.ncbi.nlm.nih.gov/28207247
https://pubmed.ncbi.nlm.nih.gov/28207247
Autor:
Michael J. Thwaites, Ian Welch, Paul G. Cantalupo, James I. MacDonald, Gustavo Leone, James M. Pipas, Jean-Leon Chong, Maria Teresa Sáenz-Robles, P. M. Stafford, Matthew J. Cecchini, Frederick A. Dick, Srikanth Talluri, Sarah M. Francis, Daniel Thompsen Passos
Publikováno v:
Paediatrics Publications
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report, we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1fe65729195b15e8e3b13ea856a76a
https://doi.org/10.1128/mcb.01589-13
https://doi.org/10.1128/mcb.01589-13
Autor:
Yudith Ramos-Valdes, Pirunthan Perampalam, Gabriel E. DiMattia, James I. MacDonald, Larissa Litovchick, Frederick A. Dick
Publikováno v:
Molecular cancer research : MCR. 15(4)
Epithelial ovarian cancer (EOC) generates multicellular aggregates called spheroids that detach from the primary tumor and disseminate through ascites. Spheroids possess a number of characteristics of tumor dormancy including withdrawal from the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf037f8d1448b9163da76c4dff8ac36
https://pubmed.ncbi.nlm.nih.gov/28031411
https://pubmed.ncbi.nlm.nih.gov/28031411