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pro vyhledávání: '"James Hughes-Hallett"'
Autor:
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1331-1346 (2017)
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. We find that the mTORC1 pathway i
Externí odkaz:
https://doaj.org/article/2f396a16f2994d80bba511cc91261878
Publikováno v:
Bio-Protocol, Vol 11, Iss 7 (2021)
The Target of Rapamycin kinase Complex I (TORC1) is the master regulator of cell growth and metabolism in eukaryotes. In the presence of pro-growth hormones and abundant nutrients, TORC1 is active and drives protein, lipid, and nucleotide synthesis b
Externí odkaz:
https://doaj.org/article/b05cda5863894d05a3875e863df509b4
Autor:
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj
Publikováno v:
Nature Communications. 13
Purine nucleotides are necessary for various biological processes related to cell proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-dependent reactions, the impact of changes in cellular purine levels on
Autor:
James Hughes-Hallett, Issam Ben-Sahra, John M. Asara, Rebecca C. Timson, Gerta Hoxhaj, Erika Ilagan, Brendan D. Manning, Min Yuan
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1331-1346 (2017)
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. We find that the mTORC1 pathway i