Zobrazeno 1 - 10
of 106
pro vyhledávání: '"James Hubert"'
Autor:
Douglas G. Johns, Sheng‐Ping Wang, Raymond Rosa, James Hubert, Suoyu Xu, Ying Chen, Thomas Bateman, Robert O. Blaustein
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib d
Externí odkaz:
https://doaj.org/article/c8e1dc786577458ead4c45f5d1a68e5f
Autor:
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp
Externí odkaz:
https://doaj.org/article/bd0a1abbb701431196775362cf9f8457
Autor:
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1223-1231 (2012)
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mic
Externí odkaz:
https://doaj.org/article/6c63ed70b4314113b68773d0b93c3352
We introduce MOS, a software application designed to facilitate the deployment, integration, management, and analysis of mathematical optimization models. MOS approaches mathematical optimization at a higher level of abstraction than existing optimiz
Externí odkaz:
http://arxiv.org/abs/2210.03813
Autor:
Robert O. Blaustein, Sheng-Ping Wang, James Hubert, Thomas Bateman, Douglas G. Johns, Suoyu Xu, Ray Rosa, Ying Chen
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad465789ceb40706052713bb2f4e0244
https://doaj.org/article/c8e1dc786577458ead4c45f5d1a68e5f
https://doaj.org/article/c8e1dc786577458ead4c45f5d1a68e5f
Autor:
David G. McLaren, CarolAnn Keohan, Stephanie Williams, Steven R. Bartz, Andy Liaw, Yong Ma, Shirly Pinto, Karen O. Akinsanya, Stephen F. Previs, Yanqing Kan, Marija Tadin-Strapps, Steven J. Stout, Kristian K. Jensen, Ablatt Mahsut, James Hubert, David Coelho, Martin Koser, Gail Forrest, Kithsiri Herath, Satya Yendluri, Shubing Wang, Sheng-Ping Wang
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
Journal of Lipid Research
Journal of Lipid Research
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af37a914ad8babe8855bb8f3efecb08f
http://www.sciencedirect.com/science/article/pii/S0022227520345417
http://www.sciencedirect.com/science/article/pii/S0022227520345417
Autor:
James, Hubert M.
Publikováno v:
Science, 1949 Sep 01. 110(2854), 254-256.
Externí odkaz:
https://www.jstor.org/stable/1676261
Publikováno v:
Journal of the American College of Surgeons. 229:e100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4097cd28a644d6251f016881320d188c
https://doi.org/10.1016/j.jamcollsurg.2019.08.987
https://doi.org/10.1016/j.jamcollsurg.2019.08.987
Autor:
Marc L. Reitman, Ann E. Weber, Douglas J. MacNeil, Alison M. Strack, Liping Wang, Drew T. Weingarth, Jie Pan, Susan J. Lee, Scott D. Edmondson, Su Qian, James Hubert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2911-2915
A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e404299f5f1bca8802c531b821e538c
https://doi.org/10.1016/j.bmcl.2011.03.069
https://doi.org/10.1016/j.bmcl.2011.03.069