Zobrazeno 1 - 10
of 32
pro vyhledávání: '"James Hose"'
Publikováno v:
eLife, Vol 11 (2022)
Stress defense and cell growth are inversely related in bulk culture analyses; however, these studies miss substantial cell-to-cell heterogeneity, thus obscuring true phenotypic relationships. Here, we devised a microfluidics system to characterize m
Externí odkaz:
https://doaj.org/article/2dd2e93fa21a4ea383f1ecfdd4dffd62
Publikováno v:
eLife, Vol 10 (2021)
Copy number variation through gene or chromosome amplification provides a route for rapid phenotypic variation and supports the long-term evolution of gene functions. Although the evolutionary importance of copy-number variation is known, little is u
Externí odkaz:
https://doaj.org/article/60c4fbf3b4ee4f4b847914fd36d28baa
Autor:
James Hose, Leah E Escalante, Katie J Clowers, H Auguste Dutcher, DeElegant Robinson, Venera Bouriakov, Joshua J Coon, Evgenia Shishkova, Audrey P Gasch
Publikováno v:
eLife, Vol 9 (2020)
Aneuploidy is highly detrimental during development yet common in cancers and pathogenic fungi – what gives rise to differences in aneuploidy tolerance remains unclear. We previously showed that wild isolates of Saccharomyces cerevisiae tolerate ch
Externí odkaz:
https://doaj.org/article/015b68d9383a453c8abee8df8945d841
Autor:
Maria Sardi, Vaishnavi Paithane, Michael Place, De Elegant Robinson, James Hose, Dana J Wohlbach, Audrey P Gasch
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007217 (2018)
Cellulosic plant biomass is a promising sustainable resource for generating alternative biofuels and biochemicals with microbial factories. But a remaining bottleneck is engineering microbes that are tolerant of toxins generated during biomass proces
Externí odkaz:
https://doaj.org/article/8c9636feeed74395b7be1ed65a02ec32
Autor:
Audrey P Gasch, Feiqiao Brian Yu, James Hose, Leah E Escalante, Mike Place, Rhonda Bacher, Jad Kanbar, Doina Ciobanu, Laura Sandor, Igor V Grigoriev, Christina Kendziorski, Stephen R Quake, Megan N McClean
Publikováno v:
PLoS Biology, Vol 15, Iss 12, p e2004050 (2017)
From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcrip
Externí odkaz:
https://doaj.org/article/51d8d3ea4fa0474dbdc545da373ef4c2
Autor:
Deborah Chasman, Yi‐Hsuan Ho, David B Berry, Corey M Nemec, Matthew E MacGilvray, James Hose, Anna E Merrill, M Violet Lee, Jessica L Will, Joshua J Coon, Aseem Z Ansari, Mark Craven, Audrey P Gasch
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 11, Pp 1-23 (2014)
Abstract Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet knowledge of the complete stress‐activated regulatory network as well as design principles for signal integration remains incomplete. We developed
Externí odkaz:
https://doaj.org/article/06b8235ccb524af8a37b83247b850aa4
Publikováno v:
eLife, Vol 5 (2016)
In our prior work by Hose et al., we performed a genome-sequencing survey and reported that aneuploidy was frequently observed in wild strains of S. cerevisiae. We also profiled transcriptome abundance in naturally aneuploid isolates compared to isog
Externí odkaz:
https://doaj.org/article/8c811a0c6b904ee88e52a87c782ff8a7
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/b4190a990f334352814ac9166ad96b14
Autor:
M Violet Lee, Scott E Topper, Shane L Hubler, James Hose, Craig D Wenger, Joshua J Coon, Audrey P Gasch
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-12 (2011)
Abstract The transcriptome and proteome change dynamically as cells respond to environmental stress; however, prior proteomic studies reported poor correlation between mRNA and protein, rendering their relationships unclear. To address this, we combi
Externí odkaz:
https://doaj.org/article/b781cc2aee754377a36fca0dc42dfafe
Publikováno v:
eLife, Vol 4 (2015)
Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuplo
Externí odkaz:
https://doaj.org/article/4bbf92d5c31740ccb98691b403a85116