Zobrazeno 1 - 10
of 36
pro vyhledávání: '"James Heym"'
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d09a810f898eefeb7fda3442e4b30f
https://doi.org/10.1021/jm050069n
https://doi.org/10.1021/jm050069n
Publikováno v:
Neuropsychopharmacology. 14:225-231
N-demethylation of the selective serotonin reuptake inhibitor sertraline to desmethylsertraline yields a compound with 10- to 20-fold less potency at blocking serotonin (5-HT) reuptake as measured in vitro. In the present study desmethylsertraline (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b1a7dbbb3eaece78cdffc2e7309bf7
https://doi.org/10.1016/0893-133x(95)00112-q
https://doi.org/10.1016/0893-133x(95)00112-q
Autor:
Carol A. Burkhart, James Heym, B. K. Koe, J. L. Ives, L. K. Torgersen, Macor John E, David W. Schulz, J. A. Nielsen, Kevin Ryan, M. E. Newman, Lorraine A. Lebel
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eab1f743fccc4ea2326e82a5270c27c
https://doi.org/10.1002/chin.199104230
https://doi.org/10.1002/chin.199104230
Autor:
James Heym, James P. Rizzi, Karen J. Guarino, J. L. Ives, Terry J. Rosen, Jolanta Nowakowski, June Daffeh, Arthur Adam Nagel, Seeger Thomas Francis, Alan H. Ganong, Anne W. Schmidt, Chester J. Siok, Stafford McLean, Lawrence A. Vincent
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7872c01fd2095f9a8852ba4938bc0a6
https://doi.org/10.1002/chin.199110163
https://doi.org/10.1002/chin.199110163
Autor:
Fredric J. Vinick, J. S. Furman, Patricia A. Seymour, Howard Harry R, Lawrence A. Vincent, Linda Reynolds, Arthur Adam Nagel, Seeger Thomas Francis, J. A. Iii Lowe, P. R. Maloney, James Heym, Frank E. Ewing, M. E. Newman, G. Robinson, Anne W. Schmidt
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8490a5c1116ea797891f6e624cafa93c
https://doi.org/10.1002/chin.199146221
https://doi.org/10.1002/chin.199146221
Autor:
Zack Saud, Victoria J. Tyrrell, Andreas Zaragkoulias, Majd B. Protty, Evelina Statkute, Anzelika Rubina, Kirsten Bentley, Daniel A. White, Patricia Dos Santos Rodrigues, Robert C. Murphy, Harald Köfeler, William J. Griffiths, Jorge Alvarez-Jarreta, Richard William Brown, Robert G. Newcombe, James Heyman, Manon Pritchard, Robert WJ. Mcleod, Arvind Arya, Ceri-Ann Lynch, David Owens, P Vince Jenkins, Niklaas J. Buurma, Valerie B. O’Donnell, David W. Thomas, Richard J. Stanton
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100208- (2022)
The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its molecular composition is undetermined. Addressing this knowledge gap could support the design of antiviral agents
Externí odkaz:
https://doaj.org/article/6b2447ff65c14140a877f16e61623047
Autor:
Linda Reynolds, John A. Lowe, Alan H. Ganong, Kara G. Pratt, Seeger Thomas Francis, James Heym, Stafford McLean, Dianne K. Bryce, Chester J. Siok
Publikováno v:
Science. 251:437-439
CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7b5638657fc9714321e1818598314a
https://doi.org/10.1126/science.1703324
https://doi.org/10.1126/science.1703324
Autor:
Dianne K. Bryce, Kelly P. Longo, Manoj C. Desai, Stafford McLean, R.M. Snider, Terry J. Rosen, Anne W. Schmidt, James Heym
Publikováno v:
Regulatory peptides. 46(1-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58efa5b150b71214df13a9b82f661678
https://pubmed.ncbi.nlm.nih.gov/8210497
https://pubmed.ncbi.nlm.nih.gov/8210497
Autor:
James Heym, B. K. Koe, Lorraine A. Lebel, L. K. Torgersen, M. E. Newman, David W. Schulz, Macor John E, Carol A. Burkhart, Kevin Ryan, J. A. Nielsen, J. L. Ives
Publikováno v:
Serotonin: Molecular Biology, Receptors and Functional Effects ISBN: 9783034872614
The in vitro and in vivo characteristics of CP-93,129 [Structure 1 in Figure 1, 3-(1,2,5,6-tetrahydropyrid-4-yl)-pyrrolo[3,2-b]pyrid-5-one] are described. This rotationally restricted phenolic analog of RU-24,969 is a potent (15 nm) and selective (20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee362e0297f11b0faa89b6ff36cc81b9
https://doi.org/10.1007/978-3-0348-7259-1_45
https://doi.org/10.1007/978-3-0348-7259-1_45
