Zobrazeno 1 - 10
of 26
pro vyhledávání: '"James Hejna"'
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes. Nuclear comple
Externí odkaz:
https://doaj.org/article/8fe9549407f44530a4bb84f3c415fd49
Publikováno v:
Nucleic Acids Research
We demonstrate an application of atomic force microscopy (AFM) for the structural analysis of long single-stranded RNA (>1 kb), focusing on 28S ribosomal RNA (rRNA). Generally, optimization of the conditions required to obtain three-dimensional (3D)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2036d87dd2cb1a651e46cf5ddeb5a145
https://doi.org/10.1093/nar/gkx502
https://doi.org/10.1093/nar/gkx502
Autor:
Robb E. Moses, Susan B. Olson, Navid Ziaie, Scott Rennie, Nichole Owen, Amy E. Hanlon Newell, Asia D. Mitchell, James Hejna
Publikováno v:
Cytogenetic and Genome Research. 144:255-263
Biallelic mutations in BLM cause Bloom syndrome (BS), a genome instability disorder characterized by growth retardation, sun sensitivity and a predisposition to cancer. As evidence of decreased genome stability, BS cells demonstrate not only elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da81fa69a80ae06d196e6fa0464d31e1
https://doi.org/10.1159/000375247
https://doi.org/10.1159/000375247
Publikováno v:
Journal of Biological Chemistry. 288:22437-22450
Naturally transformable bacteria recombine internalized ssDNA with a homologous resident duplex (chromosomal transformation) or complementary internalized ssDNAs (plasmid or viral transformation). Bacillus subtilis competence-induced DprA, RecA, SsbB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48cd206fba920c7216c79e12dbc4fbf
https://doi.org/10.1074/jbc.m113.478347
https://doi.org/10.1074/jbc.m113.478347
Publikováno v:
Journal of Nanomedicine Research. 4
The first observation of double-stranded DNA by atomic force microscopy in the late 1980’s greatly encouraged many biological researchers to jump into the nano-world. Here we briefly review the history of how AFM has been utilized to reveal nanomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8e73929cbd70966d7b539919b73cc8
https://doi.org/10.15406/jnmr.2016.04.00089
https://doi.org/10.15406/jnmr.2016.04.00089
Publikováno v:
DNA Replication, Recombination, and Repair ISBN: 9784431558712
Fanconi anemia (FA) is a hereditary disorder characterized by bone marrow failure and genome instability that is ascribed to defective DNA interstrand cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7989b5c9da2480a7428cf3a88de4bf
https://doi.org/10.1007/978-4-431-55873-6_8
https://doi.org/10.1007/978-4-431-55873-6_8
Publikováno v:
Cell Biology International. 34:893-899
The FA (Fanconi anaemia) FANCD2 protein is pivotal in the cellular response to DNA interstrand cross-links. Establishing cells expressing exogenous FANCD2 has proven to be difficult compared with other DNA repair genes. We find that in transformed no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d337d6baf17c927387be8bc928b2d156
https://doi.org/10.1042/cbi20090251
https://doi.org/10.1042/cbi20090251
Autor:
James Hejna, Yassmine Akkari, Petra M. Jakobs, Roger A. Schultz, Andrew Hemphill, P.S. North, Markus Grompe, Susan B. Olson, Scott Rennie, Robb E. Moses, Amy E. Hanlon Newell, I.D. Hickson, Daniel Pauw
Publikováno v:
Hemphill, A.W.; Akkari, Y.; Newell, A.H.; Schultz, R.A.; Grompe, M.; North, P.S.; Hickson, I.D.; Jakobs, P.M.; Rennie, S.; Pauw, D.; Hejna, J.; Olson, S.B.; Moses, R.E. (2009). Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents. Cytogenetic and genome research, 125(3), pp. 165-75. Basel: Karger 10.1159/000230001
The Bloom protein (BLM) and Topoisomerase IIIalpha are found in association with proteins of the Fanconi anemia (FA) pathway, a disorder manifesting increased cellular sensitivity to DNA crosslinking agents. In order to determine if the association r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4152bb62c0b317a81397fbccda199811
https://doi.org/10.1159/000230001
https://doi.org/10.1159/000230001
Autor:
Donald A. Bruun, Yassmine Akkari, Stephen N. Jones, Susan B. Olson, James Hejna, Petra M. Jakobs, K. Hejna, Robb E. Moses, Aaron Hemphill, Yumi Torimaru, L. Thrun
Publikováno v:
Molecular Genetics and Metabolism. 94:38-45
The protein encoded by SNM1 in Saccharomyces cerevisiae has been shown to act specifically in DNA interstrand crosslinks (ICL) repair. There are five mammalian homologs of SNM1, including Artemis, which is involved in V(D)J recombination. Cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ce8e1784e54685691d05752131d17a
https://doi.org/10.1016/j.ymgme.2007.11.012
https://doi.org/10.1016/j.ymgme.2007.11.012
Autor:
Susan B. Olson, Muhsen Al-Dhalimy, Lauren Mathewson, Megan L. Holtorf, Robb E. Moses, James Hejna, Jennie Hines, Aaron Hemphill
Publikováno v:
Journal of Biological Chemistry. 283:9844-9851
The disease Fanconi anemia is a genome instability syndrome characterized by cellular sensitivity to DNA interstrand cross-linking agents, manifest by decreased cellular survival and chromosomal aberrations after such treatment. There are at least 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c99ee6b61bb2b15c58fd9608e4f19d
https://doi.org/10.1074/jbc.m709076200
https://doi.org/10.1074/jbc.m709076200