Zobrazeno 1 - 10
of 43
pro vyhledávání: '"James H. Wible"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 35:87-96
This study evaluated diclofenac concentrations in plasma, selected hind limb tissues and synovial fluid after repeated topical applications of two diclofenac formulations. Group 1 Gottingen minipigs (n = 18) were administered diclofenac sodium 2.0% t
Autor:
James H. Wible, Andrew A. Brayman, Christy K. Holland, E. Carr Everbach, Michalakis Averkiou, Junru Wu, Douglas L. Miller
Publikováno v:
Journal of Ultrasound in Medicine. 27:611-632
Diagnostic ultrasound contrast agents have been developed for enhancing the echogenicity of blood and for delineating other structures of the body. Approved agents are suspensions of gas bodies (stabilized microbubbles), which have been designed for
Autor:
Alicia M. Napoli, John Carson Allen, James H. Wible, Jennifer C. Lee, Michael D. Elliott, Raymond J. Kim, Timothy S. E. Albert, Michele Parker, Robert M. Judd
Publikováno v:
Circulation. 117:629-637
Background— The identification and assessment of myocardial infarction (MI) are important for therapeutic and prognostic purposes, yet current recommended diagnostic strategies have significant limitations. We prospectively tested the performance o
Publikováno v:
American Journal of Roentgenology. 189:1539-1544
The purpose of this study was to use three analytic methods to measure serum calcium concentration to assess the magnitude and time course of the effects of four gadolinium-based contrast agents.After providing informed consent, 12 healthy adult volu
Publikováno v:
Journal of Magnetic Resonance Imaging. 19:133-140
Purpose To evaluate the safety of OptiMARK® (gadoversetamide injection) administered via power injector. Materials and Methods The study population included 144 healthy volunteers aged 18 years or older randomly assigned to one of seven treatment gr
Autor:
I. Kofi Adzamli, James H. Wible, M. Peri Periasamy, Max D. Adams, Jon M. Chia, Sebastian Flacke, John S. Allen, Christine H. Lorenz
Publikováno v:
Radiology. 226:731-738
To determine the contrast agent behavior of gadolinium-based (extracellular and albumin-binding) and manganese-based contrast media for late-enhancement imaging of myocardial infarction.Coronary ligation was performed in 30 rats, and they were serial
Autor:
James H. Wible, Alexander L. Klibanov, Gary H. Brandenburger, Jolette K. Wojdyla, Michael S. Hughes
Publikováno v:
Academic Radiology. 9:S41-S45
Disappearance of ultrasound (US) contrast agents (gasfilled microbubbles) after contrast agent administration in the bloodstream occurs by way of several mechanisms. First, microbubbles are filtered and captured by various organs, including uptake by
Autor:
Adams, Michael R. Hynes, Karen P. Galen, James H. Wible, Steven J. Barco, Troup Cm, Jolette K. Wojdyla, MacDonald, Periasamy Mp
Publikováno v:
Investigative Radiology. 36:401-412
RATIONALE AND OBJECTIVES A series of preclinical tests were undertaken during the developmental process to determine the safety profile of gadoversetamide injection (OptiMARK). METHODS Acute intravenous, acute intracisternal, and repeated-dose toxici
Publikováno v:
Investigative Radiology. 36:292-298
This study assessed the cardiovascular effects of gadoversetamide and other gadolinium chelates administered at high rates of injection.Anesthetized beagles were instrumented to record the electrocardiogram and to measure arterial blood pressure. In
Publikováno v:
Investigative Radiology. 33:871-879
Inhaled gas mixtures with increased amounts of oxygen cause air containing ultrasound contrast agents to lose efficacy faster than during the inhalation of air. The authors hypothesized that contrast materials containing relatively insoluble gases wo