Zobrazeno 1 - 10
of 42
pro vyhledávání: '"James H. Nettles"'
Autor:
Lee M. Greenberger, James P. Snyder, James H. Nettles, Daniel B. Morilla, Sylvia Musto, Xingzhi Tan, Tami Annable, Frank Loganzo, Malathi Hari
Supplementary Methods, Table S1, and Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca061ceeaa1e350cdcad6d22ac13913
https://doi.org/10.1158/1535-7163.22487253.v1
https://doi.org/10.1158/1535-7163.22487253.v1
Autor:
Lee M. Greenberger, James P. Snyder, James H. Nettles, Daniel B. Morilla, Sylvia Musto, Xingzhi Tan, Tami Annable, Frank Loganzo, Malathi Hari
Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well understood. We sought to characterize the resistance mechanisms that develop upon chronic expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5148b28f08d4a0c6373d0e8916ec00f7
https://doi.org/10.1158/1535-7163.c.6532473.v1
https://doi.org/10.1158/1535-7163.c.6532473.v1
Autor:
Joseph A Hollenbaugh, Jadd Shelton, Sijia Tao, Sheida Amiralaei, Peng Liu, Xiao Lu, Russell W Goetze, Longhu Zhou, James H Nettles, Raymond F Schinazi, Baek Kim
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169052 (2017)
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD
Externí odkaz:
https://doaj.org/article/7585f5c3a1dc4457859860a505db1ff0
Autor:
Debra A Wadford, Robert C Kauffman, Jesse D Deere, Scott T Aoki, Richard A Stanton, Joanne Higgins, Koen K A Van Rompay, Andradi Villalobos, James H Nettles, Raymond F Schinazi, Niels C Pedersen, Thomas W North
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86997 (2014)
RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1 (HIV-1) within the backbone of SIVmac239. It has been used in a non-human primate model for s
Externí odkaz:
https://doaj.org/article/5f1423224fd94d54b2ae48fbe6d694ee
Autor:
Margaret Sharenko, James H. Nettles, Mark Hyman Rapaport, Dedric Carroll, Erika R. Larson, Pamela J. Schettler, Becky Kinkead
Publikováno v:
Focus (American Psychiatric Publishing). 16(1)
This article reviews the current state of knowledge of the role of massage therapy in the treatment of common psychiatric disorders and symptoms. It briefly discusses the prevalence of psychiatric disorders and the popularity of complementary and int
Autor:
Boadie W. Dunlop, Dedric Carroll, Mylin A. Torres, Margaret Sharenko, James H. Nettles, Erika R. Larson, Becky Kinkead, Mark Hyman Rapaport, Pamela J. Schettler, Sherry A. Edwards, Andrew H. Miller, Jeffrey J. Rakofsky
Publikováno v:
Cancer. 124:546-554
BACKGROUND Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. In this study, we evaluated the efficacy of weekly Swedish massage therapy (SMT) versus an act
Autor:
Catherine Montero, James H. Nettles, Mervi Detorio, Emily T. Hammond, Michel Feraud, Raymond F. Schinazi, Richard A. Stanton, Robert A. Domaoal, Maryam Ehteshami, Xiao Lu
Publikováno v:
Bioorg Med Chem Lett
A library of 585 compounds built off a 7-azaindole core was evaluated for anti-HIV-1 activity, and ten hits emerged with submicromolar potency and therapeutic index >100. Of these, three were identified as non-nucleoside reverse transcriptase (RT) in
Autor:
Raymond F. Schinazi, Sijia Tao, Tony Whitaker, Sebastien Boucle, Tamara R. McBrayer, James H. Nettles, Franck Amblard, Steven J. Coats, Chengwei Li, Richard A. Stanton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3711-3715
The design and synthesis of new non-symmetrical NS5A inhibitors with sulfur containing amino acids is reported along with their ability to block HCV replication in an HCV 1b replicon system. These compounds display EC50 values in the picomolar range
Autor:
Raymond F. Schinazi, James H. Nettles, Steven J. Coats, Hongwang Zhang, Tamara R. McBrayer, Longhu Zhou, Joshua Broyde, Richard A. Stanton, Junxing Shi, James J. Kohler, Tony Whitaker, Franck Amblard
Publikováno v:
Journal of Medicinal Chemistry
Symmetric, dimeric daclatasvir (BMS-790052) is the clinical lead for a class of picomolar inhibitors of HCV replication. While specific, resistance-bearing mutations at positions 31 and 93 of domain I strongly suggest the viral NS5A as target, struct
Autor:
Sheida Amiralaei, Raymond F. Schinazi, Jadd R. Shelton, Longhu Zhou, Russell W. Goetze, Joseph A. Hollenbaugh, Xiao Lu, James H. Nettles, Sijia Tao, Baek Kim, Peng Liu
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169052 (2017)
PLoS ONE
PLoS ONE
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD