Zobrazeno 1 - 10
of 245
pro vyhledávání: '"James H. Meador-Woodruff"'
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Schizophrenia is a complex and multifactorial disorder associated with altered neurotransmission as well as numerous signaling pathway and protein trafficking disruptions. The pH of intracellular organelles involved in protein trafficking is
Externí odkaz:
https://doaj.org/article/18f02550c16b49ef9b70d0f2efbbff81
Schizophrenia (SCZ) is a chronic psychiatric disorder that is associated with neuronal dysfunction. Recently, the autophagy pathway in the brain has become a target of investigation in this illness. Autophagy is a homeostatic process that serves as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f292c6a57a2f77d9a320a5edb50e5983
https://doi.org/10.21203/rs.3.rs-1896079/v1
https://doi.org/10.21203/rs.3.rs-1896079/v1
Publikováno v:
Molecular Psychiatry. 26:6868-6879
The AKT-mTOR signaling transduction pathway plays an important role in neurodevelopment and synaptic plasticity. mTOR is a serine/threonine kinase that modulates signals from multiple neurotransmitters and phosphorylates specific proteins to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c8dc6ef9b64d51575f608dca2e18e2
https://doi.org/10.1038/s41380-021-01135-9
https://doi.org/10.1038/s41380-021-01135-9
Autor:
Robert E. McCullumsmith, James H. Meador-Woodruff, Anita Pinner, Toni M. Mueller, Khaled Alganem
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-9 (2020)
Translational Psychiatry
Translational Psychiatry
The pathophysiology of schizophrenia includes altered neurotransmission, dysregulated intracellular signaling pathway activity, and abnormal dendritic morphology that contribute to deficits of synaptic plasticity in the disorder. These processes all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac4a4fce5cfce92e5d8b644b703e47a
http://link.springer.com/article/10.1038/s41398-019-0610-7
http://link.springer.com/article/10.1038/s41398-019-0610-7
Publikováno v:
Molecular psychiatry
Abnormalities in protein localization, function, and post-translational modifications (PTMs) are targets of schizophrenia (SCZ) research. As a major contributor to the synthesis, folding, trafficking, and modification of proteins, the endoplasmic ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8851bbb78b8e26b2e5b5d68382f5096
http://europepmc.org/articles/PMC7113111
http://europepmc.org/articles/PMC7113111
Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in Mammalian frontal cortex.
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94255 (2014)
Protein glycosylation may contribute to the evolution of mammalian brain complexity by adapting excitatory neurotransmission in response to environmental and social cues. Balanced excitatory synaptic transmission is primarily mediated by glutamatergi
Externí odkaz:
https://doaj.org/article/e877a02b15f24fff950a05351b17ec2c
Autor:
Xiaojun Wu, James Reigle, Erica A K DePasquale, James H. Meador-Woodruff, Vahram Haroutunian, Rammohan Shukla, Emily Devine, Margaret Hahn, Micah Simmons, Christy Au-Yeung, Khaled Alganem, Jarek Meller, Chang-Gyu Hahn, Xiaolu Zhang, Hunter M. Eby, Roshanak Asgariroozbehani, Robert E. McCullumsmith
Publikováno v:
Molecular psychiatry. 26(12)
While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac833ff095fae4b1578dd65e7ecd839
https://pubmed.ncbi.nlm.nih.gov/34272489
https://pubmed.ncbi.nlm.nih.gov/34272489
Publikováno v:
Molecular psychiatry. 26(11)
The AKT-mTOR signaling transduction pathway plays an important role in neurodevelopment and synaptic plasticity. mTOR is a serine/threonine kinase that modulates signals from multiple neurotransmitters and phosphorylates specific proteins to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7f8916d454925513532ad77358de6fa
https://pubmed.ncbi.nlm.nih.gov/33990769
https://pubmed.ncbi.nlm.nih.gov/33990769
Publikováno v:
Schizophrenia research. 223
Though the pathophysiology of schizophrenia remains poorly understood, altered brain energy metabolism is increasingly implicated. Here, we conduct meta-analyses of the available human studies measuring lactate or pH in schizophrenia brain and discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59093a8bad7bd6a7e3afa0a7ff559ed
https://pubmed.ncbi.nlm.nih.gov/32958361
https://pubmed.ncbi.nlm.nih.gov/32958361
Publikováno v:
npj Schizophrenia, Vol 6, Iss 1, Pp 1-16 (2020)
NPJ Schizophrenia
NPJ Schizophrenia
Research investigating the pathophysiology of schizophrenia has not yet precisely defined the molecular phenotype of this disorder. Many studies have investigated cellular dysfunction by examining expression levels of molecular targets in postmortem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2f5ec52cdcd845d19e68bc0f4fa2d3
https://doi.org/10.1038/s41537-020-0093-9
https://doi.org/10.1038/s41537-020-0093-9