Zobrazeno 1 - 10
of 457
pro vyhledávání: '"James H. McKerrow"'
Autor:
Mahmud Usman, Audu Joseph Natala, Isa Danladi Jatau, Ndudim Isaac Ogo, Ghulam Jeelani, Yasuyuki Goto, Tomoyoshi Nozaki, James H. McKerrow, Emmanuel Oluwadare Balogun
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionFemale sand flies are hematophagous, feeding on animals and in the process serve as vectors for Leishmania, the parasites that cause leishmaniasis in humans. Leishmaniasis are a group of parasitic neglected tropical diseases in 98 countri
Externí odkaz:
https://doaj.org/article/0f389d7b814b47fbaf717d3083f23ad8
Autor:
Mateus Sá Magalhães Serafim, Simone Queiroz Pantaleão, Elany Barbosa da Silva, James H. McKerrow, Anthony J. O’Donoghue, Bruno Eduardo Fernandes Mota, Kathia Maria Honorio, Vinícius Gonçalves Maltarollo
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Computer-Aided Drug Design (CADD) approaches, such as those employing quantitative structure-activity relationship (QSAR) methods, are known for their ability to uncover novel data from large databases. These approaches can help alleviate the lack of
Externí odkaz:
https://doaj.org/article/e2db8cf43a7740b480f9cbd0085bc576
Autor:
Jean A. Bernatchez, Yun-Seo Kil, Elany Barbosa da Silva, Diane Thomas, Laura-Isobel McCall, Karen L. Wendt, Julia M. Souza, Jasmin Ackermann, James H. McKerrow, Robert H. Cichewicz, Jair L. Siqueira-Neto
Publikováno v:
ACS Omega, Vol 7, Iss 9, Pp 7675-7682 (2022)
Externí odkaz:
https://doaj.org/article/a44ac6911af84676a0399e9101b954d0
Autor:
Esdras Matheus Gomes da Silva, Karina Mastropasqua Rebello, Young-Jun Choi, Vitor Gregorio, Alexandre Rossi Paschoal, Makedonka Mitreva, James H. McKerrow, Ana Gisele da Costa Neves-Ferreira, Fabio Passetti
Publikováno v:
Pathogens, Vol 11, Iss 11, p 1273 (2022)
RNA sequencing (RNA-Seq) and mass-spectrometry-based proteomics data are often integrated in proteogenomic studies to assist in the prediction of eukaryote genome features, such as genes, splicing, single-nucleotide (SNVs), and single-amino-acid vari
Externí odkaz:
https://doaj.org/article/946fa43d3952454b918b331539a85356
Autor:
Ittipat Meewan, Jacob Kattoula, Julius Y. Kattoula, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, James H. McKerrow, Jair Lage de Siqueira-Neto, Anthony J. O’Donoghue, Ruben Abagyan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 744 (2022)
One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key
Externí odkaz:
https://doaj.org/article/657345c2310e45a7868c20618d38774e
Autor:
Adwaita R. Parab, Diane Thomas, Sharon Lostracco-Johnson, Jair L. Siqueira-Neto, James H. McKerrow, Pieter C. Dorrestein, Laura-Isobel McCall
Publikováno v:
Pathogens, Vol 10, Iss 5, p 593 (2021)
Cutaneous leishmaniasis (CL) is the most common disease form caused by a Leishmania parasite infection and considered a neglected tropical disease (NTD), affecting 700,000 to 1.2 million new cases per year in the world. Leishmania major is one of sev
Externí odkaz:
https://doaj.org/article/c5dc602a072f4fc3bee7b6e86933c2a9
Autor:
Rahul Tyagi, Christina A. Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin, James H. McKerrow, Case W. McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W. Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva
Publikováno v:
Pathogens, Vol 10, Iss 1, p 71 (2021)
Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult para
Externí odkaz:
https://doaj.org/article/4b9a387fd8184bb3b46400e12541ea35
Autor:
Jean A. Bernatchez, Emily Chen, Mitchell V. Hull, Case W. McNamara, James H. McKerrow, Jair L. Siqueira-Neto
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 472 (2020)
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, affects between 6 and 7 million people worldwide, with an estimated 300,000 to 1 million of these cases in the United States. In the chronic phase of infection, T. cruzi can caus
Externí odkaz:
https://doaj.org/article/82e0aa90e04d44c59825e25e98d6ef55
Autor:
Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J. O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H. McKerrow, Charles S. Craik, Conor R. Caffrey, José F. Tort
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue mi
Externí odkaz:
https://doaj.org/article/d4c2423d90c340b9bc971306ed846e6a
Autor:
Anjan Debnath, Andrew T. Nelson, Angélica Silva-Olivares, Mineko Shibayama, Dionicio Siegel, James H. McKerrow
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Primary amebic meningoencephalitis (PAM) is a fatal infection caused by the free-living ameba Naegleria fowleri, popularly known as the “brain-eating ameba.” The drugs of choice in treating PAM are the antifungal amphotericin B and an antileishma
Externí odkaz:
https://doaj.org/article/30fad2f52c5d423d826a91d1e9c3fd37