Zobrazeno 1 - 10
of 38
pro vyhledávání: '"James H. Ludens"'
Autor:
Stephen J. Humphrey, James H. Ludens
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:894-903
We determined the effects of the K-adenosine triphosphate (ATP)-blocking diuretic PNU-37883A on plasma renin activity (PRA) in conscious and anesthetized dogs. In conscious dogs, oral PNU-37883A (6-60 mg/kg) was less potent than hydrochlorothiazide (
Autor:
Jui R. Shah, James Laredo, Matthew J. Hamilton, Keizo Kimura, James H. Ludens, Zhuo Ren Lu, Paolo Manunta, John M. Hamlyn, James P. Hamilton, Bruce P. Hamilton
Publikováno v:
Clinical and Experimental Hypertension. 20:523-533
The human circulation contains four readily distinguishable biologically active inhibitors of the sodium pump that appear to be endogenous to mammals. Of these, one has been purified to homogeneity and by numerous chromatographic, mass spectral, bioc
Autor:
Garner T. Haupert, James H. Ludens, Nina Berova, Koji Nakanishi, Lee-Chiang Lo, Adrienne A. Tymiak, Ning Zhao
Publikováno v:
Biochemistry. 34:9893-9896
The specific, high affinity binding of plant-derived digitalis glycosides by the mammalian sodium and potassium transporting adenosine triphosphatase (Na,K-ATPase, or sodium pump), a plasma membrane enzyme with critical physiological importance in ma
Publikováno v:
American Journal of Physiology-Renal Physiology. 269:F242-F247
Previous reports have shown that K+ channel openers elevate plasma renin activity in vivo and stimulate renin release (RR) from juxtaglomerular (JG) cells in vitro. Therefore, we examined whether the K+ channel blocker, glyburide, inhibits basal RR o
Publikováno v:
Journal of Cardiovascular Pharmacology. 22:S38-S41
Previous studies demonstrated that ouabain-like compound (OLC) is widely distributed in mammalian species and is found in a variety of different tissues. Although much evidence suggests that OLC is endogenous to mammals, little information is availab
Autor:
Donald W. DuCharme, Douglas W. Harris, Michael A. Clark, Karen P. Kolbasa, John M. Hamlyn, James H. Ludens, Jed F. Fisher
Publikováno v:
Hypertension. 17:936-943
Recently, attempts to purify and identify a circulating inhibitor of the sodium pump have been successful. Based on the outcome of mass spectral analysis of purified inhibitor, we raised in rabbits antibodies to conjugates of the commercially availab
Autor:
Douglas W. Harris, John M. Hamlyn, Donald W. DuCharme, James H. Ludens, Michael A. Clark, B. S. Lutzke, F Mandel, D M Sutter, W R Mathews
Publikováno v:
Hypertension. 17:923-929
In previous reports, we described the isolation and characterization of an endogenous digitalislike factor (EDLF). In this report, we describe a unique combination of bioassay and large-scale purification methodology that made possible the purificati
Autor:
Douglas W. Harris, James H. Ludens, W R Mathews, John M. Hamlyn, Donald W. DuCharme, F Mandel, Michael A. Clark
Publikováno v:
Hypertension. 17:930-935
A sodium pump inhibitor has been isolated from human plasma and extensively purified. This material, endogenous digitalislike factor, was examined by a variety of mass spectrometric techniques. A low-resolution fast atom bombardment mass spectrometri
Publikováno v:
European Journal of Pharmacology. 193:275-281
Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied in conscious normotensive rats either after a single administra
Publikováno v:
Journal of cardiovascular pharmacology. 25(3)
The ATP-sensitive K + channel blocker U-37883A was given intravenously (i.v.) to rats to determine if pharmacologic diversity among ATP-sensitive K + channels observed in vitro is also apparent in vivo. Vascular K + channel blockade was quantified as