Výsledky vyhledávání - "James H. Herts"

Abstract LB009: Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment

Autor: Jason W. Eng, L.A. Naiche, Bhairavi Swaminathan, Yu Kato, Krishna Thakkar, Katherine Ann Alexander, Rahul Vadakath, James H. Herts, Rajyasree Emmadi, Junji Matsui, Jan K. Kitajewski

Publikováno v: Cancer Research. 83:LB009-LB009

The Notch signaling pathway, particularly endothelial Notch signaling, plays a key role in tumor formation and angiogenesis. Inhibiting Notch1 or its ligand, Delta-like ligand 4 (Dll4), can induce hypersprouting of the tumor vasculature and thus can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94b5a687b72b028931d5c398e5e91c3a
https://doi.org/10.1158/1538-7445.am2023-lb009

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Abstract 1488: A novel Notch4 neutralizing antibody inhibits angiogenesis and tumor growth via a distinct mechanism from endothelial Notch1 inhibition

Autor: Sarita Das, Krishna Thakkar, Jan Kitajewski, Bhairavi Swaminathan, James H. Herts, Yu Kato, Qanber Raza, Jason W. Eng, L. A. Naiche, Junji Matsui, Rajyasree Emmadi

Publikováno v: Cancer Research. 80:1488-1488

Endothelial Notch signaling is critical for tumor angiogenesis and growth. Inhibitors of Notch1 or its ligand Dll4 cause tumor vessel hypersprouting but interfere with vessel perfusion causing reduced tumor growth. Unfortunately, normal tissue vessel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07f5dd18658b9cb23be66552c2ba84f2
https://doi.org/10.1158/1538-7445.am2020-1488

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