Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James H. Frederich"'
Publikováno v:
ACS Omega, Vol 5, Iss 39, Pp 25029-25035 (2020)
Externí odkaz:
https://doaj.org/article/4891be44636e411581e091eee26dcc6d
Publikováno v:
Organic Letters. 24:6499-6504
A stereoselective synthetic entry point to the 5-8-5 carbocyclic core of the ophiobolins was developed. This strategy exploits the chiral tertiary alcohol of ophiobolin A to guide assmebly of the 5-8-5 scaffold in a single step via a photoinitiated c
Publikováno v:
Organic Letters. 24:1907-1912
Publikováno v:
Angew Chem Int Ed Engl
Methyl groups are ubiquitous in biologically active molecules. Thus, new tactics to introduce this alkyl fragment into polyfunctional structures are of significant interest. With this goal in mind, a direct method for the Markovnikov hydromethylation
Publikováno v:
Journal of the American Chemical Society. 144(14)
A new polyene cyclization strategy exploiting β-ionyl derivatives was developed. Photoinduced deconjugation of the extended π-system within these chromophores unveils a contrathermodynamic polyene that engages in a Heck bicyclization to afford [4.4
Publikováno v:
Organic letters. 24(10)
A method for the photoinduced evolution of atomic oxygen from pyridazine
Publikováno v:
ACS Chemical Biology. 15:305-310
Fusicoccin A (FC) is a diterpene glycoside that stabilizes protein–protein interactions (PPIs) between 14–3–3 adapter proteins and their phosphoprotein interaction partners. Recently, FC has gained attention for its pro-apoptotic and neuroprote
Publikováno v:
Asian Journal of Organic Chemistry. 8:1111-1114
Autor:
Maribel Borger, James H. Frederich
Publikováno v:
Org Lett
A method to transform pyridazine N-oxides into 2-aminofurans using a combination of UV light and transition metal catalysis has been developed. These electron-rich species exhibit a surprising range of useful reactivity, including the ability to part
Publikováno v:
Chemical Science. 9:5389-5393
A 5–8–5 carbocyclic ring system forms the core of over 30 distinct natural products. Several members of this family have gained attention for their diverse activity in cell culture. In these cases, biological function is mediated by the arrangeme