Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James H. Dawahare"'
Autor:
Christopher D Kegelman, Hope B Pearson, Joel D. Boerckel, Liming Zhao, Devon E. Mason, James H. Dawahare, Melissa A. Kacena
Publikováno v:
Tissue Eng Part A
Insufficient blood vessel supply is a primary limiting factor for regenerative approaches to large bone defect repair. Recombinant bone morphogenetic protein-2 (BMP-2) delivery induces robust bone formation and has been observed to enhance neovascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f011afb5099b5e942a4d28c1c6a310
https://doi.org/10.1089/ten.tea.2018.0326
https://doi.org/10.1089/ten.tea.2018.0326
Autor:
Joseph M. Collins, Joel D. Boerckel, Pinar Zorlutuna, Sherry L. Voytik-Harbin, Mervin C. Yoder, James H. Dawahare, Devon E. Mason, Yang Lin, Trung Dung Nguyen
Publikováno v:
The Journal of Cell Biology
The importance of transcription during cell motility is controversial. Mason et al. show that YAP/TAZ-mediated transcription is required to limit cytoskeletal tension generation and permit persistent cell motility. This pathway is defined as a negati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b196a112b83d9e64de122ce79a9178d
https://doi.org/10.1083/jcb.201806065
https://doi.org/10.1083/jcb.201806065
Autor:
Madhura P. Nijsure, Kelsey M Jordan, Christopher D Kegelman, Joel D. Boerckel, James H. Dawahare, Ling Qin, Yasaman Moharrer, Hope B Pearson
In response to bone fracture, periosteal progenitor cells proliferate, expand, and differentiate to form cartilage and bone in the fracture callus. These cellular functions require the coordinated activation of multiple transcriptional programs, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a16402c0405c8bd96c8a170d3e6780
Autor:
Daniel S. Alt, Honghyun Park, Yuxuan Cheng, Joel D. Boerckel, P. C. Wong, Felicia He, Anna D. Dikina, Samuel Herberg, Yu Bin Lee, Phuong N. Dang, Alexandra McMillan, Rui Tang, James H. Dawahare, Eben Alsberg, Daniel Varghai, Kentaro Umemori, Anna M. McDermott, Jung Youn Shin
Publikováno v:
Science Advances
Mesenchymal condensations promote defect repair by mimicking cellular, morphogenetic, and mechanical aspects of bone development.
Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell c
Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60f8942e445a052dfb5cdf82e165d23
https://doi.org/10.1126/sciadv.aax2476
https://doi.org/10.1126/sciadv.aax2476
Autor:
Joel D. Boerckel, Hope B Pearson, Daniel J. Kelly, Eben Alsberg, Amit Patwa, Anna M. McDermott, Devon E. Mason, James H. Dawahare, Samuel Herberg, Mark W. Grinstaff, Rui Tang, Joseph M. Collins
Publikováno v:
Science Translational Medicine. 11
Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature bone. However, natural fractur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc79e16ab18d83b751e874e794276150
https://doi.org/10.1126/scitranslmed.aav7756
https://doi.org/10.1126/scitranslmed.aav7756
Autor:
Samuel Herberg, Honghyun Park, Felicia He, Phuong N. Dang, Anna D. Dikina, Daniel Varghai, Yuxuan Cheng, Joel D. Boerckel, Alexandra McMillan, Yu Bin Lee, Daniel S. Alt, Jung Youn Shin, P. C. Wong, Anna M. McDermott, Eben Alsberg, James H. Dawahare, Kentaro Umemori, Rui Tang
Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation and is directed by local morphogen signals and mechanical cues. Here, we aimed to mimic these developmental conditions for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8351e76ec2eba1111980c4f1ed9262
https://doi.org/10.1101/561837
https://doi.org/10.1101/561837
Autor:
Devon E. Mason, Liming Zhao, James H. Dawahare, Joel D. Boerckel, Christopher D Kegelman, Hope B Pearson, Melissa A. Kacena
Insufficient blood vessel supply is a primary limiting factor for regenerative approaches to large bone defect repair. Recombinant BMP-2 delivery induces robust bone formation and has been observed to enhance neovascularization, but whether the angio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc412bbb4a7e80b05ec48a519b4538d
https://doi.org/10.1101/464396
https://doi.org/10.1101/464396
Autor:
James H. Dawahare, Mervin E Yoder, Yang Lin, Trung Dung Nguyen, Devon E. Mason, Sherry L. Voytik-Harbin, Joel D. Boerckel, Pinar Zorlutuna
Cell migration initiates by traction generation through reciprocal actomyosin tension and focal adhesion reinforcement, but continued motility requires adaptive cytoskeletal remodeling and adhesion release. Here, we asked whetherde novogene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbe82694968adb19511003a7d4827ba
https://doi.org/10.1101/265744
https://doi.org/10.1101/265744
Autor:
Christopher D Kegelman, Alexander G. Robling, Joel D. Boerckel, James H. Dawahare, Genevieve D. Vigil, Devon E. Mason, Scott S. Howard, Teresita Bellido, Daniel J. Horan
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5)
The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each has been observed to promote or inhibit osteogenesis in vitro, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51e751cae856c3ee0cc5971914575c1
https://pubmed.ncbi.nlm.nih.gov/29401582
https://pubmed.ncbi.nlm.nih.gov/29401582
Autor:
Anna M. McDermott, Samuel Herberg, Devon E. Mason, Hope B. Pearson, James H. Dawahare, Joseph M. Collins, Rui Tang, Amit N. Patwa, Mark W. Grinstaff, Daniel J. Kelly, Eben Alsberg, Joel D. Boerckel
Large bone defects cannot heal without intervention and have high complication rates even with the best treatments available. In contrast, bone fractures naturally healing with high success rates by recapitulating the process of bone development thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bd09b4effdf2c93392e443e27f49c4