Zobrazeno 1 - 10
of 44
pro vyhledávání: '"James H. Cook"'
Autor:
Eric P. Gillis, Kyle Parcella, Michael Bowsher, James H. Cook, Christiana Iwuagwu, B. Narasimhulu Naidu, Manoj Patel, Kevin Peese, Haichang Huang, Lourdes Valera, Chunfu Wang, Kasia Kieltyka, Dawn D. Parker, Jean Simmermacher, Eric Arnoult, Robert T. Nolte, Liping Wang, John A. Bender, David B. Frennesson, Mark Saulnier, Alan Xiangdong Wang, Nicholas A. Meanwell, Makonen Belema, Umesh Hanumegowda, Susan Jenkins, Mark Krystal, John F. Kadow, Mark Cockett, Robert Fridell
Publikováno v:
Journal of Medicinal Chemistry. 66:1941-1954
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec60862845d7a9e3c5ea18ee8c48c091
https://doi.org/10.1021/acs.jmedchem.2c01732
https://doi.org/10.1021/acs.jmedchem.2c01732
Autor:
Hyunsoo Park, James H. Cook, Ivar M. McDonald, Bradley C. Pearce, Matthew D. Hill, Haiquan Fang, John E. Macor, Lizbeth Gallagher, F. Christopher Zusi, Richard E. Olson, Linda J. Bristow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5002-5005
We describe an efficient and convergent synthesis of a series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c17ad27adf8439455974f7b5770b18
https://doi.org/10.1016/j.bmcl.2017.10.009
https://doi.org/10.1016/j.bmcl.2017.10.009
Autor:
Regina Miller, Nicholas J. Lodge, John E. Macor, Wendy Clarke, Lizbeth Gallagher, Linda J. Bristow, Daniel G. Morgan, Christiana I. Iwuagwu, Ryan Westphal, Haiquan Fang, Kimberley A. Lentz, Debra J. Post-Munson, Amy Easton, Matthew D. Hill, Bei Wang, Robert A. Mate, Ivar M. McDonald, James H. Cook, Yulia Benitex, Dalton King, Thaddeus F. Molski, Ronald J. Knox, F. Christopher Zusi, Richard E. Olson, Rex Denton, Jingsong Fan, Rulin Zhao, Robert Zaczek
Publikováno v:
ACS Medicinal Chemistry Letters. 8:366-371
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4993c640b254a344e08c8bc412ffe3
https://doi.org/10.1021/acsmedchemlett.7b00032
https://doi.org/10.1021/acsmedchemlett.7b00032
Autor:
Kevin Peese, Joseph E. Carpenter, James H. Cook, Gillis Eric P, Catherine A. Bolger, Peter S. Dragovich, T. G. Murali Dhar, Achal Pashine, J. Robert Merritt
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014e3316d1824afef46c3b6e89c3031b
https://doi.org/10.29200/acsmedchemrev-v53.ch29
https://doi.org/10.29200/acsmedchemrev-v53.ch29
Autor:
James H. Cook
Of all that has been written of the cowboy and the life of the cattle range, very little has been written by the principal actors themselves. The same is equally true of the famous government scouts, mail riders and other adventurous figures, who wer
Autor:
Regina Miller, Michele Matchett, Nicholas J. Lodge, Yulia Benitex, Thaddeus F. Molski, Wendy Clarke, John E. Macor, Rulin Zhao, Robert Zaczek, Linda J. Bristow, Amy Easton, Christiana I. Iwuagwu, JoAnne E Natale, Haiquan Fang, Ronald J. Knox, Baoqing Ma, F. Christopher Zusi, Siva Digavalli, James H. Cook, Matthew D. Hill, Francine L. Healy, Debra J. Post-Munson, Jingfang Qian Cutrone, Daniel G. Morgan, Bei Wang, Richard E. Olson, Qi Gao, Rex Denton, Robert A. Mate, Ivar M. McDonald, Dalton King, Meredith Ferrante, Kimberley A. Lentz, Kelli M. Jones, Judith A. Siuciak, Lizbeth Gallagher
Publikováno v:
Journal of medicinal chemistry. 59(24)
The design and synthesis of a series of quinuclidine-containing spirooxazolidines (“spiroimidates”) and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7168f463fa8dafe0bc3dd8512c11678
https://pubmed.ncbi.nlm.nih.gov/27958732
https://pubmed.ncbi.nlm.nih.gov/27958732
Autor:
Daniel G. Morgan, Wendy Clarke, Nicholas J. Lodge, Yulia Benitex, John E. Macor, Debra J. Post-Munson, Ivar M. McDonald, Richard E. Olson, Dalton King, Rex Denton, Amy Easton, Ronald J. Knox, Kimberley A. Lentz, Christiana I. Iwuagwu, Matthew D. Hill, F. Christopher Zusi, Haiquan Fang, Robert Zaczek, Linda J. Bristow, Robert A. Mate, James H. Cook, Regina Miller
We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c72cac8d11dcb33041f5390751e60f
https://europepmc.org/articles/PMC5238485/
https://europepmc.org/articles/PMC5238485/
Autor:
Lizbeth Gallagher, Debra Post-Munson Amy Easton, Ivar M. McDonald, Dalton King, Nicholas J. Lodge, Regina Miller, Robert Zaczek, John E. Macor, James H. Cook, F. Christopher Zusi, Ronald J. Knox, Linda J. Bristow, Yulia Benitex, Judy Siuciak, Matthew D. Hill, Daniel G. Morgan, Robert A. Mate, Christiana I. Iwuagwu, Haiquan Fang, Richard E. Olson
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c9a03ebb524178d61755d17d99cd4c
https://pubmed.ncbi.nlm.nih.gov/28169167
https://pubmed.ncbi.nlm.nih.gov/28169167
Autor:
Debra J. Post-Munson, Ping Chen, Linda J. Bristow, Daniel G. Morgan, Ryan Westphal, Kelli M. Jones, Adam Hendricson, Lizbeth Gallagher, Dalton King, Yulia Benitex, Richard Pieschl, Digavalli V. Sivarao, Christiana I. Iwuagwu, Robert Zaczek, Regina Lidge, Nicholas J. Lodge, John E. Macor, Amy Easton, James H. Cook, Yu-Wen Li, Thaddeus F. Molski, Richard E. Olson, Christopher Daly
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0159996 (2016)
PLoS ONE, Vol 11, Iss 7, p e0159996 (2016)
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e845cf9f7d9cd9aa45b681f10cc5d9bb
http://europepmc.org/articles/PMC4965148
http://europepmc.org/articles/PMC4965148
Publikováno v:
Journal of Geriatric Physical Therapy. 28:34-38
Although exercise has both physical and psychological benefits, most older adults do not exercise on a regular basis. Physical therapists need to explore ways to encourage sustained commitment. This article proposes that cognitive factors contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a94fa695717b556952f5cc7af3dfa7
https://doi.org/10.1519/00139143-200508000-00001
https://doi.org/10.1519/00139143-200508000-00001