Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James H. Bourell"'
Autor:
Kevin R Clark, Thomas R. Gadek, Martin E. Struble, James H. Bourell, Denise A. Ockey, Jenna Dotson, John T. Stults
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:37-44
A novel class of nonpeptide inhibitors of stromelysin (MMP-3) has been discovered with the use of mass spectrometry. The method relies on the development of structure–activity relationships by mass spectrometry (SAR by MS) and utilizes information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b66b0c91c5bac46b85e9ceadce0c11c
https://doi.org/10.1016/j.bmc.2003.10.053
https://doi.org/10.1016/j.bmc.2003.10.053
Autor:
William J. Henzel, James H. Bourell, Christopher Grimley, Susan C. Wong, Todd M. Billeci, John T. Stults
Publikováno v:
Methods. 6:239-247
A method for in situ digestion that allows high recovery of peptides at the low picomole level from two-dimensional gel electroblotted proteins is described. Peptides obtained from in situ digests were analyzed by matrix-assisted laser desorption/ io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138a25a2728bca89389bbf915cda1bc5
https://doi.org/10.1006/meth.1994.1026
https://doi.org/10.1006/meth.1994.1026
Publikováno v:
Analytical Chemistry. 66:2088-2095
Mass spectrometry has been used to confirm the correct protein expression of Fab and F(ab')2 fragments of the humanized anti-p185HER2 antibody huMAb4D5. These data demonstrate that electrospray ionization mass spectrometry can be used routinely to me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eece5fd7903aae3e9dbfa38b1b5ec64c
https://doi.org/10.1021/ac00085a026
https://doi.org/10.1021/ac00085a026
Autor:
James H. Bourell, Glenn C. Rice, Daniel G. Yansura, William J. Henzel, Steven A. Spencer, Richard Horuk, Elaine N. Unemori, Dorothea Reilly
Publikováno v:
Journal of Biological Chemistry. 268:541-546
Human melanoma growth stimulating activity (MGSA) is a mitogenic factor first identified in the conditioned media of human melanoma cells. Structurally, MGSA belongs to a superfamily of proteins that includes interleukin-8 (IL-8) and platelet factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd7126522d8024600e1325fda46a309
https://doi.org/10.1016/s0021-9258(18)54185-5
https://doi.org/10.1016/s0021-9258(18)54185-5
Publikováno v:
Journal of Biological Chemistry. 266:22063-22066
Tissue factor, a 45-kilodalton membrane glycoprotein, is an essential cofactor for the plasma serine protease factor VII which activates factor X in the first step of the extrinsic coagulation cascade. Two adjacent lysine residues (numbers 165 and 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8962cad60161d71e5c1c734e1339df28
https://doi.org/10.1016/s0021-9258(18)54745-1
https://doi.org/10.1016/s0021-9258(18)54745-1
Autor:
Victor Ling, Gary R. Laramee, John W. Winslow, Eleanor Canova-Davis, James H. Bourell, John T. Stults, Richard Vandlen, Ernst H. Rinderknecht, Patrick R. Griffin
Publikováno v:
Biological Mass Spectrometry. 19:655-664
Mass spectrometry has played a key role in characterizing the primary structure of native and recombinant relaxin, a peptide hormone that induces ripening of the cervix prior to childbirth. The peptide is composed of two chains, A and B, and is forme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c4941456b9486bb1cfd77b95a2134c
https://doi.org/10.1002/bms.1200191105
https://doi.org/10.1002/bms.1200191105
Publikováno v:
Journal of Chromatography A. 512:299-314
The combination of high-performance displacement chromatography with continuous flow fast atom bombardment (FAB)-mass spectrometry (MS) offers a means of overcoming the sample capacity limitations imposed by the low flow-rates tolerated in microbore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73270e55a2846501762f9cb6ce8ace3f
https://doi.org/10.1016/s0021-9673(01)89497-8
https://doi.org/10.1016/s0021-9673(01)89497-8
Publikováno v:
Analytical Biochemistry. 187:228-233
An HPLC system incorporating a packed capillary C18 column has been utilized for high sensitivity peptide mapping and preparative collection for protein sequencing. This system combined with a Frit-FAB mass spectrometer interface also provides the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30e55dd64d76e01f0ba84d1467fcb15
https://doi.org/10.1016/0003-2697(90)90448-i
https://doi.org/10.1016/0003-2697(90)90448-i
Autor:
M Brochier, James H. Bourell, James A. Wells, Steven H. Bass, Michael G. Mulkerrin, N McFarland, Germaine Fuh, David R. Light
Publikováno v:
Journal of Biological Chemistry. 265:3111-3115
A gene fragment encoding the extracellular domain of the human growth hormone (hGH) receptor from liver was cloned into a plasmid under control of the Escherichia coli alkaline phosphatase promoter and the heat-stable enterotoxin (StII) signal peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca6dbb93c9898891d8653e399e2899b
https://doi.org/10.1016/s0021-9258(19)39741-8
https://doi.org/10.1016/s0021-9258(19)39741-8
Autor:
Wayne J. Fairbrother, James H. Bourell, Beth L. Gillece-Castro, Laura DeForge, Paul H. Slagle, Henry B. Lowman, Cynthia M. Wirth
Publikováno v:
The Journal of biological chemistry. 271(24)
Interleukin-8 (IL-8), a CXC chemokine, is known to bring about chemotaxis and activation of neutrophils through high affinity binding to at least two distinct receptors, receptor-A and receptor-B. The IL-8 homolog melanoma growth stimulating activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4a2be78515fc114029a733d6c499d7
https://pubmed.ncbi.nlm.nih.gov/8662882
https://pubmed.ncbi.nlm.nih.gov/8662882