Výsledky vyhledávání - "James H Wikel"

Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models

Autor: Emily Hulsey, Olivia Babb, Silpa Gampala, Bumsoo Han, Rachel A. Caston, Randall Wireman, Hye-ran Moon, Andi R. Masters, James H. Wikel, Melissa L. Fishel, George E. Sandusky, Millie M. Georgiadis, Mark R. Kelley, Sara K. Quinney, Nayela N. Chowdhury

Publikováno v: Cancer Research. 81:1452-1452

Targeted therapy for cancer using small molecules has progressed exponentially, but agents that can affect cancer cells rather than non-tumorigenic cells are crucial to avoid pernicious side effects. AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f26d119d57c371c631e2636829c28ab
https://doi.org/10.1158/1538-7445.am2021-1452

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Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization

Autor: Fenil Shah, Timothy W. Corson, Rania S. Sulaiman, Trupti Shetty, Mark R. Kelley, Kamakshi Sishtla, James H. Wikel, Melissa L. Fishel, Bomina Park, Sheik Pran Babu Sardar Pasha

Publikováno v: J Pharmacol Exp Ther

Ocular neovascular diseases like wet age-related macular degeneration are a major cause of blindness. Novel therapies are greatly needed for these diseases. One appealing antiangiogenic target is reduction-oxidation factor 1-apurinic/apyrimidinic end

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Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy

Autor: James H. Wikel, Mark R. Kelley, Chunlu Guo, Michael R. Vasko, Melissa L. Fishel, Karen E. Pollok, Barbara J. Bailey, Randy Wireman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 359(2)

Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially debilitating side effect of a number of chemotherapeutic agents. There are currently no U.S. Food and Drug Administration-approved interventions or prevention strategies for CIPN. Alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53932b7391d11bc3851cbbfbf7b3b882
https://pubmed.ncbi.nlm.nih.gov/27608656

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Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

Autor: Charles M. Beasley, Steven A. Wrighton, James H. Wikel, William J. Crumb, Christopher Carlson, Sean Ekins, R. Dustan Sarazan

Publikováno v: Pharmaceutical Research. 23:1133-1143

To evaluate in vitro and computationally model the effects of selected antipsychotic drugs on several ionic currents that contribute to changes in the action potential in cardiac tissue.Fourteen antipsychotic drugs or metabolites were examined to det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37310dab3af464164f65554b1daac37
https://doi.org/10.1007/s11095-006-0070-7

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Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

Autor: Mark A. Winter, James H. Wikel, Lu-Bin Lan, John D. Schuetz, Sean Ekins, Kazuto Yasuda, Anne H. Dantzig, Robert L. Shepard, Brenda F. Leake, Erin G. Schuetz, Steven A. Wrighton, Richard B. Kim

Publikováno v: Molecular Pharmacology. 61:964-973

P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavailability and tissue penetration of a variety of structurally divergent molecules. A better understanding of the structural requirements of modulators of P-gp function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8af447e299be29454bd336e72bc016
https://doi.org/10.1124/mol.61.5.964

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Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

Autor: James H. Wikel, Erin G. Schuetz, Robert L. Shepard, Anne H. Dantzig, Brenda F. Leake, Richard B. Kim, Lu-Bin Lan, Mark A. Winter, Steven A. Wrighton, Kazuto Yasuda, Sean Ekins, John D. Schuetz

Publikováno v: Molecular Pharmacology. 61:974-981

Using in vitro data, we previously built Catalyst 3-dimensional quantitative structure activity relationship (3D-QSAR) models that qualitatively rank and predict IC(50) values for P-glycoprotein (P-gp) inhibitors. These models were derived and tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e3662b48b7b989b3f0dd59f2a785b
https://doi.org/10.1124/mol.61.5.974

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Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Autor: Gregory L. Durst, Richard A. Lewis, Loncharich Richard James, Robert E. Stratford, James H. Wikel, Sean Ekins, David A. Thorner

Publikováno v: Journal of Chemical Information and Computer Sciences. 41:1578-1586

Multiple three-dimensional quantitative structure-activity relationship (3D-QSAR) approaches were applied to predicting passive Caco-2 permeability for a series of 28 inhibitors of rhinovirus replication. Catalyst, genetic function approximation (GFA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd699c1a3dc061e66657ac27a1655a5
https://doi.org/10.1021/ci010330i

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Progress in predicting human ADME parameters in silico

Autor: Gabriele Cruciani, James H. Wikel, Steven A. Wrighton, Sean Ekins, Peter W. Swaan, Chris L. Waller

Publikováno v: Journal of Pharmacological and Toxicological Methods. 44:251-272

Understanding the development of a scientific approach is a valuable exercise in gauging the potential directions the process could take in the future. The relatively short history of applying computational methods to absorption, distribution, metabo

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https://doi.org/10.1016/s1056-8719(00)00109-x

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Application of MS-WHIM Descriptors: 3. Prediction of Molecular Properties

Autor: James H. Wikel, Gianpaolo Bravi

Publikováno v: Quantitative Structure-Activity Relationships. 19:39-49

MS-WHIM descriptors were developed in attempt to capture global 3D chemical information at molecular surface level. Initially, they contained information about size, shape and electrostatic distribution of a molecule. More recently they were enriched

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25de1b1b0bfb3d7069c111d930275a34
https://doi.org/10.1002/(sici)1521-3838(200002)19:1<39::aid-qsar39>3.0.co

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