Zobrazeno 1 - 10
of 874
pro vyhledávání: '"James H Doroshow"'
Autor:
Jiamo Lu, Guojian Jiang, Yongzhong Wu, Smitha Antony, Jennifer L Meitzler, Agnes Juhasz, Han Liu, Krishnendu Roy, Hala Makhlouf, Rodrigo Chuaqui, Donna Butcher, Mariam M Konaté, James H Doroshow
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233208 (2020)
To facilitate functional investigation of the role of NADPH oxidase 1 (NOX1) and associated reactive oxygen species in cancer cell signaling, we report herein the development and characterization of a novel mouse monoclonal antibody that specifically
Externí odkaz:
https://doaj.org/article/ebb8d7dabc614df08b60c032e03783fa
Autor:
Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199361 (2018)
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents fo
Externí odkaz:
https://doaj.org/article/f5177b4e279648b6b9d11f4b1381c950
Publikováno v:
Cancer Informatics, Vol 16 (2017)
Cellular glycosylation processes are vital to cell functioning. In malignant cells, they are profoundly altered. We used time-course gene expression data from the NCI-60 cancer cell lines treated with 11 antitumor agents to analyze expression changes
Externí odkaz:
https://doaj.org/article/3cfe3fa4e9cd4e3b8d817d51c70fa28d
Autor:
Jiuping Ji, Yiping Zhang, Christophe E Redon, William C Reinhold, Alice P Chen, Laura K Fogli, Susan L Holbeck, Ralph E Parchment, Melinda Hollingshead, Joseph E Tomaszewski, Quentin Dudon, Yves Pommier, James H Doroshow, William M Bonner
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171582 (2017)
Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs), but the variability of H2AX expression in different cell and tissue types makes it difficult to interpret the meaning of the γ-H2AX level. Furthermore, the assa
Externí odkaz:
https://doaj.org/article/c5271db0c4334b48803bddf775b6a904
Autor:
Priya Balasubramanian, Robert J Kinders, Shivaani Kummar, Vishal Gupta, David Hasegawa, Anoop Menachery, Scott M Lawrence, Lihua Wang, Katherine Ferry-Galow, Darren Davis, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175414 (2017)
Circulating tumor cells (CTCs) are increasingly employed for research and clinical monitoring of cancer, though most current methods do not permit the isolation of non-epithelial tumor cells. Furthermore, CTCs isolated with antibody-dependent methods
Externí odkaz:
https://doaj.org/article/5a1c9b8ca8394270b95ad7bdc380301a
Autor:
Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, Eric M. Jones, Li Chen, Jianwen Fang, Joel Morris, Jeffrey A. Moscow, James H. Doroshow, Beverly A. Teicher
Publikováno v:
SLAS Discovery, Vol 29, Iss 7, Pp 100186- (2024)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates genes of drug transporters and metabolic enzymes to detoxify small molecule xenobiotics. It has a complex role in cancer biology, influencing both the progr
Externí odkaz:
https://doaj.org/article/d5d6e57234014b9b957345d8f7354e31
Autor:
Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTHistone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such t
Externí odkaz:
https://doaj.org/article/76cdf0bfff0e453b87e8b5bd10e9b649
Autor:
William C Reinhold, Sudhir Varma, Fabricio Sousa, Margot Sunshine, Ogan D Abaan, Sean R Davis, Spencer W Reinhold, Kurt W Kohn, Joel Morris, Paul S Meltzer, James H Doroshow, Yves Pommier
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101670 (2014)
Exome sequencing provides unprecedented insights into cancer biology and pharmacological response. Here we assess these two parameters for the NCI-60, which is among the richest genomic and pharmacological publicly available cancer cell line database
Externí odkaz:
https://doaj.org/article/057d0edf6e504c459a7b470d013e1b18
Autor:
R Steven Esworthy, Byung-Wook Kim, Guillermo E Rivas, Thomas L Leto, James H Doroshow, Fong-Fong Chu
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44262 (2012)
Mice that are deficient for glutathione peroxidases 1 and 2 (GPX) show large variations in the penetrance and severity of colitis in C57BL/6J and 129S1/SvImJ backgrounds. We mapped a locus contributing to this difference to distal chromosome 2 (∼11
Externí odkaz:
https://doaj.org/article/3056a4521df64603834eeefdeb122086
Autor:
Thomas D Pfister, Melinda Hollingshead, Robert J Kinders, Yiping Zhang, Yvonne A Evrard, Jiuping Ji, Sonny A Khin, Suzanne Borgel, Howard Stotler, John Carter, Raymond Divelbiss, Shivaani Kummar, Yves Pommier, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50494 (2012)
Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a c
Externí odkaz:
https://doaj.org/article/fc45c0d607034df99dbf3dba3216402a