Zobrazeno 1 - 4
of 4
pro vyhledávání: '"James G. Tarrant"'
Autor:
Darlene Romashko, James G. Tarrant, Felix Weng, Keith R. Hornberger, Matthew R. Medeiros, Andrew Kleinberg, Peter Meyn, Dan Maarten Berger, Mark Albertella, William Peick, An-Hu Li, Mark Bittner, Jing Wang, Hanqing Dong, Paul Maresca, Mark J. Mulvihill, Earl W. May, Wilde Victoria Lynn, Kam W. Siu, Brianna Tokar, Michael Tanowitz, Michael J. Gray, Andrew P. Crew, Andrew Cooke
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(16)
The discovery and potency optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. Micromolar hits taken from high-throughput screening were optimized for biochemical and cellular mechanistic potency to ∼10 nM, as exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539f984e43b2488a1efbebe0b4c06384
https://pubmed.ncbi.nlm.nih.gov/23850198
https://pubmed.ncbi.nlm.nih.gov/23850198
Autor:
Marian Vargas, James A. Sikorski, Kirsten N. Hosein, Steve M. Bruno, D. R. Wilkinson, Scott A. Petrich, James G. Tarrant, Fred A. Hicks, John T. Gupton
Publikováno v:
Tetrahedron. 51:1575-1584
The reaction of unsymmetrical vinylogous iminum salts and related analogs with β-aminocrotononitrile to yield 2,3,6-trisubstituted pyridines with regioselective control is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdda88901cc443739fff50b0e804c372
https://doi.org/10.1016/0040-4020(94)01039-3
https://doi.org/10.1016/0040-4020(94)01039-3
Autor:
James A. Sikorski, John T. Gupton, Fred A. Hicks, Kirsten N. Hosein, D. R. Wilkinson, James G. Tarrant, Scott A. Petrich, Steve M. Bruno, Marian Vargas
Publikováno v:
ChemInform. 26
The reaction of unsymmetrical vinylogous iminum salts and related analogs with β-aminocrotononitrile to yield 2,3,6-trisubstituted pyridines with regioselective control is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662820c53c8eefdb351d3d80f0e0e31d
https://doi.org/10.1002/chin.199530158
https://doi.org/10.1002/chin.199530158
Publikováno v:
Synthetic Communications. 22:3205-3214
An efficient and convenient synthesis of chain lengthened homologs of the important fungicide Metalaxyl is described. The starting material utilized is 2,6-dimethylaniline and the sequence is accomplished utilizing Grignard reactions and ruthenium ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c65a7fd16b897c879159952c526f481
https://doi.org/10.1080/00397919208021134
https://doi.org/10.1080/00397919208021134