Zobrazeno 1 - 10
of 41
pro vyhledávání: '"James G. Simmons"'
Autor:
Praveen Sethupathy, Bailey C.E. Peck, P. Kay Lund, James G. Simmons, John Sincavage, Sydney Feinstein, Amanda T. Mah
Publikováno v:
The Journal of Biological Chemistry
Proliferation and differentiation of intestinal epithelial cells (IECs) occur in part through precise regulation of key transcription factors, such as SOX9. MicroRNAs (miRNAs) have emerged as prominent fine-tuners of transcription factor expression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468f525f9550618aebeef78955d6dbe2
https://pubmed.ncbi.nlm.nih.gov/27261459
https://pubmed.ncbi.nlm.nih.gov/27261459
Publikováno v:
Molecular Cancer Research. 9:1718-1731
The IL-6/STAT3 and TNFα/NFκB pathways are emerging as critical mediators of inflammation-associated colon cancer. TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/dextran sodium sulfate (AOM/DSS) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175f54a2398d626fafa5181e95354e9a
https://doi.org/10.1158/1541-7786.mcr-10-0210
https://doi.org/10.1158/1541-7786.mcr-10-0210
Autor:
Brooks Scull, Ginny H. Lee, P. Kay Lund, James G. Simmons, Kirk K. McNaughton, Heather R. Wilkins, Scott T. Magness, Nicole M. Ramocki
Publikováno v:
Endocrinology. 149:261-267
Reduced apoptosis of crypt stem/progenitor cells and elevated insulin and IGFs are linked to colon cancer risk. Insulin receptor substrate-1 (IRS-1) mediates the actions of insulin, IGF-I, and IGF-II, but the role of endogenous IRS-1 in crypt apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dc54dbec5b2cc9edfd62e804f0883d
https://doi.org/10.1210/en.2007-0869
https://doi.org/10.1210/en.2007-0869
Autor:
James G. Simmons, Warren S. Alexander, Rachael Rigby, Pauline K. Lund, Christopher J. Greenhalgh
Publikováno v:
Oncogene. 26:4833-4841
Intestinal injury or chronic inflammation induce cytokines that promote crypt regeneration and mucosal repair. If excessive or prolonged, such mechanisms may increase colon cancer risk. Factors that terminate or limit cytokine action in intestinal ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42faea0bfb948dc4c3cad2d6c01779a4
https://doi.org/10.1038/sj.onc.1210286
https://doi.org/10.1038/sj.onc.1210286
Autor:
Kirk K. McNaughton, James G. Simmons, Christopher J. Greenhalgh, Nicole M. Ramocki, Carmen Z. Michaylira, P. Kay Lund, C. Kirby Tanner, John T. Woosley
Publikováno v:
Endocrinology. 147:1632-1641
GH may improve intestinal growth or function in patients with short bowel syndrome. Excessive trophic effects of GH or IGF-I may contribute to neoplastic growth or increased colorectal cancer risk in acromegaly. Identification of mechanisms that limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8e91a2c4e7de4e568d79c3aa06a8ed
https://doi.org/10.1210/en.2005-1241
https://doi.org/10.1210/en.2005-1241
Autor:
Shira Fruchtman, James G. Simmons, Megan E. Miller, Denise M. Ney, Carmen Z. Michaylira, Christopher J. Greenhalgh, P. Kay Lund
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G342-G350
Growth hormone (GH) and IGF-I play important roles in wound healing during intestinal injury and inflammation, but there is also indirect evidence that locally expressed IGF-I may act to induce excessive collagen deposition, which can lead to intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4156a2c169d3dbf5251072ddee20cc
https://doi.org/10.1152/ajpgi.00413.2004
https://doi.org/10.1152/ajpgi.00413.2004
Autor:
P. Kay Lund, James G. Simmons, Bailey C.E. Peck, Praveen Sethupathy, Scott T. Magness, Amanda Mah
Publikováno v:
The FASEB Journal. 28
Precise regulation of SOX9 expression is critical for normal proliferation and differentiation in the intestinal epithelium. microRNAs (miRNAs) have emerged as prominent fine-tuners of gene expression. In silico sequence analyses revealed a putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1cf55aa74f0d2a23ffbeb8becc735f
https://doi.org/10.1096/fasebj.28.1_supplement.lb744
https://doi.org/10.1096/fasebj.28.1_supplement.lb744
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 276:G817-G827
Paracrine and autocrine actions of the insulin-like growth factors (IGFs) are inferred by local expression within the bowel. CCD-18Co cells, IEC-6 cells, and immunoneutralization were used to analyze whether IGFs have direct autocrine or paracrine ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76c2c16cfd24b6c309791240b5bdcae
https://doi.org/10.1152/ajpgi.1999.276.4.g817
https://doi.org/10.1152/ajpgi.1999.276.4.g817