Zobrazeno 1 - 10
of 289
pro vyhledávání: '"James G. Kench"'
Autor:
Ngee-Soon Lau, Mark Ly, Claude Dennis, Andrew Jacques, Marti Cabanes-Creus, Shamus Toomath, Joanna Huang, Nicole Mestrovic, Paul Yousif, Sumon Chanda, Chuanmin Wang, Leszek Lisowski, Ken Liu, James G. Kench, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Current machine perfusion technology permits livers to be preserved ex situ for short periods to assess viability prior to transplant. Long-term normothermic perfusion of livers is an emerging field with tremendous potential for the assessme
Externí odkaz:
https://doaj.org/article/141a2c9c97cb419e918d58706a370ec6
Autor:
Mark Ly, BMed, MS, Ngee-Soon Lau, MD, FRACS, Catriona McKenzie, MBBS, FRCPA, James G. Kench, MBBS, FRCPA, Geoffrey McCaughan, MBBS, PhD, FRACP, Michael Crawford, MBBS, MMed, FRACS, Carlo Pulitano, MD, PhD, FRACS
Publikováno v:
Transplantation Direct, Vol 9, Iss 3, p e1443 (2023)
Introduction. Biliary complications are a common cause of morbidity after liver transplantation and associated with bile duct injury. To reduce injury, a bile duct flush is performed with high-viscosity preservation solution. It has been suggested th
Externí odkaz:
https://doaj.org/article/0fdef2e62bed4bb28aace87a14bb57ab
Autor:
Mark Ly, Ngee-Soon Lau, Catriona McKenzie, James G. Kench, Doruk Seyfi, Avik Majumdar, Ken Liu, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 21, p 6793 (2023)
Introduction: Histological injury to the biliary tree during organ preservation leads to biliary strictures after liver transplantation. The Bile Duct Injury (BDI) score was developed to assess histological injury and identify the grafts most likely
Externí odkaz:
https://doaj.org/article/88cbcdb551da4d06902044d633a31214
Publikováno v:
Journal of Transplantation, Vol 2023 (2023)
Introduction. Histopathological assessment of liver biopsies is the current “gold standard” for diagnosing graft dysfunction after liver transplantation (LT), as graft dysfunction can have nonspecific clinical presentations and inconsistent patte
Externí odkaz:
https://doaj.org/article/3d518d51ba2e45baaf9a24f2964fb847
Autor:
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc‐Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 10, Pp n/a-n/a (2022)
Abstract Background Prostate cancer is a clinically heterogeneous disease with a subset of patients rapidly progressing to lethal‐metastatic prostate cancer. Current clinicopathological measures are imperfect predictors of disease progression. Epig
Externí odkaz:
https://doaj.org/article/ce0e644fc6654c8a9b89ff431e3a8d9b
Autor:
Helen Ke, MBBS (Hons), Anthony J. Gill, AM, MBBS, FRCPA, Catriona McKenzie, MBBS (Hons1), FRCPA, James G. Kench, MBBS, Bsc(Med), FRCPA, Renee C.F. Chan, MBBS(Hons1), FRCPA, Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP, Michael Fulham, MBBS(Hons), FRACP, Cherry Koh, MBBS (Hons), MS, FRACS, Steven Kao, BHB, MBChB, PhD, FRACP
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 11, Pp 100236- (2021)
Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been de
Externí odkaz:
https://doaj.org/article/4276d0c706c24f83ba19a45b265d9305
Autor:
April Morrow, Emily Hogden, Yoon-Jung Kang, Julia Steinberg, Karen Canfell, Michael J. Solomon, James G. Kench, Anthony J. Gill, Tim Shaw, Nicholas Pachter, Bonny Parkinson, Luke Wolfenden, Gillian Mitchell, Finlay Macrae, Kathy Tucker, Natalie Taylor
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Lynch syndrome (LS) is an inherited, cancer predisposition syndrome associated with an increased risk of colorectal, endometrial and other cancer types. Identifying individuals with LS allows access to cancer risk management strat
Externí odkaz:
https://doaj.org/article/8102e42f5ac24c69a569a0be9c74833c
Autor:
Shalima S. Nair, Phuc-Loi Luu, Wenjia Qu, Madhavi Maddugoda, Lily Huschtscha, Roger Reddel, Georgia Chenevix-Trench, Martina Toso, James G. Kench, Lisa G. Horvath, Vanessa M. Hayes, Phillip D. Stricker, Timothy P. Hughes, Deborah L. White, John E. J. Rasko, Justin J.-L. Wong, Susan J. Clark
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-20 (2018)
Abstract Background Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technologies, whole genome bi
Externí odkaz:
https://doaj.org/article/4b0c244e8fac47f18cdf2eed2689bdf4
Autor:
James M. Henderson, Michelle S. W. Xiang, Jiali Carrie Huang, Stefanie Wetzel, Linxuan Jiang, Jack H. Lai, Wengen Wu, James G. Kench, William W. Bachovchin, Ben Roediger, Geoffrey W. McCaughan, Hui Emma Zhang, Mark D. Gorrell
Publikováno v:
Cancers, Vol 13, Iss 21, p 5495 (2021)
The mRNA expression of the dipeptidyl peptidase 4 (DPP4) gene family is highly upregulated in human hepatocellular carcinoma (HCC) and is associated with poor survival in HCC patients. Compounds that inhibit the DPP4 enzyme family, such as talabostat
Externí odkaz:
https://doaj.org/article/04651d7d2ee047aa86a1c58c3e6fff83
Autor:
Fátima Valdés-Mora, Cathryn M. Gould, Yolanda Colino-Sanguino, Wenjia Qu, Jenny Z. Song, Kylie M. Taylor, Fabian A. Buske, Aaron L. Statham, Shalima S. Nair, Nicola J. Armstrong, James G. Kench, Kenneth M. L. Lee, Lisa G. Horvath, Minru Qiu, Alexei Ilinykh, Nicole S. Yeo-Teh, David Gallego-Ortega, Clare Stirzaker, Susan J. Clark
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistri
Externí odkaz:
https://doaj.org/article/d2ff8d2d6d19424694b455f94d09d58c