Zobrazeno 1 - 10
of 627
pro vyhledávání: '"James G. Herman"'
Autor:
Kathleen Kennedy, Ignacio Jusue-Torres, Ian D. Buller, Emily Rossi, Apurva Mallisetty, Kristen Rodgers, Beverly Lee, Martha Menchaca, Mary Pasquinelli, Ryan H. Nguyen, Frank Weinberg, Israel Rubinstein, James G. Herman, Malcolm Brock, Lawrence Feldman, Melinda C. Aldrich, Alicia Hulbert
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Despite recent advances in lung cancer therapeutics and improving overall survival, disparities persist among socially disadvantaged populations. This study aims to determine the effects of neighborhood deprivation indices (NDI) o
Externí odkaz:
https://doaj.org/article/60ad4de4b5b14a6990346e0debb7c4cb
Autor:
Yang Zhao, Christine M. O'Keefe, Kuangwen Hsieh, Leslie Cope, Sonali C. Joyce, Thomas R. Pisanic, James G. Herman, Tza‐Huei Wang
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract There remains tremendous interest in developing liquid biopsy assays for detection of cancer‐specific alterations, such as mutations and DNA methylation, in cell‐free DNA (cfDNA) obtained through noninvasive blood draws. However, liquid
Externí odkaz:
https://doaj.org/article/ff0a5e42f18e4cf0b64f4e54e2e61f2c
Publikováno v:
SLAS Technology, Vol 27, Iss 3, Pp 172-179 (2022)
Variation in methylcytosine is perhaps the most well-studied epigenetic mechanism of gene regulation. Methods that have been developed and implemented for assessing DNA methylation require sample DNA to be extracted, purified and chemically-processed
Externí odkaz:
https://doaj.org/article/55fbef407ad245bd8f7c981f0d95493c
Publikováno v:
Epigenetics, Vol 17, Iss 2, Pp 191-201 (2022)
The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide techniques, with recent public efforts yielding immense data sets of diverse malignancies repr
Externí odkaz:
https://doaj.org/article/58daba9259c643ea8da3f38b15c66f5d
Autor:
Marina Baretti, Enusha Karunasena, Marianna Zahurak, Rosalind Walker, Yang Zhao, Thomas R. Pisanic 2nd, Tza‐Huei Wang, Tim F. Greten, Austin G. Duffy, Elske Gootjes, Gerrit Meijer, Henk M.W. Verheul, Nita Ahuja, James G. Herman, Nilofer S. Azad
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 954-963 (2021)
Abstract We previously reported CHFR methylation in a subset of colorectal cancer (CRC; ∼30%) with high concordance with microsatellite instability (MSI). We also showed that CHFR methylation predicted for sensitivity to docetaxel, whereas the MSI
Externí odkaz:
https://doaj.org/article/34db3bb082a1446e8841a22732e2f3de
Autor:
Malabika Sen, Audrey Kindsfather, Ludmila Danilova, Feng Zhang, Raffaele Colombo, Matthew G. LaPorte, Brenda F. Kurland, Donna M. Huryn, Peter Wipf, James G. Herman
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 604-617 (2020)
Signal Transducers and Activators of Transcription-3 (STAT3), a potent oncogenic transcription factor, is constitutively activated in lung cancer, but mutations in pathway genes are infrequent. Protein Tyrosine Phosphatase Receptor-T (PTPRT) is an en
Externí odkaz:
https://doaj.org/article/333860db35804967959dcc5164891d1b
Publikováno v:
Biomarker Research, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among multiple tumors of the same typ
Externí odkaz:
https://doaj.org/article/761e0a5819454996828b4c822c5af76c
Autor:
Hongxia Li, Meiying Zhang, Enqiang Linghu, Fuyou Zhou, James G. Herman, Liming Hu, Mingzhou Guo
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background The role of TMEM176A in human hepatocellular carcinoma (HCC) is unknown. This study explored the epigenetic regulation and function of TMEM176A in human HCC. Materials and methods Twelve HCC cell lines and 126 cases of primary can
Externí odkaz:
https://doaj.org/article/7c8abbe1c4bb4992ad18564053f1145d
Autor:
Wenji Yan, Kongming Wu, James G. Herman, Xiuduan Xu, Yunsheng Yang, Guanghai Dai, Mingzhou Guo
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear. Methods Eight CRC cell lines and 237 cases of primary CRC were a
Externí odkaz:
https://doaj.org/article/50e3374182e04d598f49b864e57d68bf
Autor:
Yuzhu Wang, Tao He, James G. Herman, Enqiang Linghu, Yunsheng Yang, François Fuks, Fuyou Zhou, Linjie Song, Mingzhou Guo
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background ZNF331 was reported to be a transcriptional repressor. Methylation of the promoter region of ZNF331 has been found frequently in human esophageal and gastric cancers. The function and methylation status of ZNF331 remain to be eluc
Externí odkaz:
https://doaj.org/article/9debd5d1b158464a927114b65d20df77