Výsledky vyhledávání - "James G. Davidson"

Mucohalic acid in Lewis acid catalyzed Mukaiyama aldol reaction: a concise method for highly functionalized γ-substituted γ-butenolides

Autor: Daniel Belmont, James G. Davidson, Ji Zhang, Timothy T. Curran, Paul Angell

Publikováno v: Tetrahedron Letters. 46:2029-2032

The first Mukaiyama aldol reaction on mucohalic acid ( 1a / b ) has been achieved. Reaction of 1 with various ketene silyl acetals or silyl enol ethers in the presence of a Lewis acid provides the γ-substituted γ-butenolides in good to excellent yi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b929ce7c5ba87ebb75729c933d03e454
https://doi.org/10.1016/j.tetlet.2005.01.147

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First Direct Reductive Amination of Mucochloric Acid: A Simple and Efficient Method for Preparing Highly Functionalized α,β-Unsaturated γ-Butyrolactams

Autor: James G. Davidson, Ji Zhang, Peter G. Blazecka

Publikováno v: Organic Letters. 5:553-556

[reaction: see text] The first direct reductive amination of mucochloric acid (1) has been accomplished. Reaction of 1 with various alkyl, aryl, and benzylamines, followed by reduction in the same pot, provides an efficient method of obtaining N-benz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a7cdd0a8d36958c70aaee1b3f7fd03
https://doi.org/10.1021/ol0274662

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The Chemical Development of CI-972 and CI-1000: A Continuous Nitration, A MgCl2/Et3N-Mediated C-Alkylation of a Chloronitropyrimidine, A Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine

Autor: Margaret E. Kelly, Philip J. Fiore, Gary J. Dozeman, Randall L. De Jong, Ronald E. Seamans, Punam Giri, James G. Davidson, and Timothy P. Puls

Publikováno v: Organic Process Research & Development. 5:216-225

Efficient, large-scale processes were developed for the preparation of the potent PNP inhibitors 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride, monohydrate (1) and 2-amino-3,5-dihydro-7-(3-thienylmeth-yl)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5888302fd97ac7d5a4c3de5ca7ddf5c
https://doi.org/10.1021/op000298d

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A Direct and Efficient Synthesis of 5′-Deoxy-2′, 3′

Autor: Phillip J. Fiore, James G. Davidson

Publikováno v: Nucleosides and Nucleotides. 10:1477-1483

A direct and efficient synthesis of 5′-deoxy-2′,3′-O-isopropylideneinosine, 7, from readily available inosine is described. An example of a potentially general synthesis of N -substituted-5′-deoxyadenosines from 7 is also described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::997d34635924c6bc080e4a866befdd95
https://doi.org/10.1080/07328319108046676

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Amino Acid Esters and Amides for Reductive Amination of Mucochloric Acid: Synthesis of Novel γ-Lactams, Short Peptides and Antiseizure Agent Levetiracetam (Keppra®)

Autor: Ji Zhang, James G. Davidson, Yun Huang, Koushik Das Sarma

Publikováno v: ChemInform. 37

A simple methodology utilizing mucochloric acid anddifferent α- and β-amino acid esters, amides and shortpeptides for the synthesis of novel γ-lactam and γ-lactam-based short peptides was developed. The synthesis of an antiseizure agent, Levetira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059adeecd6baf7702dd1e2222a13f1e1
https://doi.org/10.1002/chin.200650122

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Efficient synthesis of novel gamma-substituted gamma-butenolides by Lewis acid catalyzed addition of metal enolates of active methylene compounds to mucohalic acids

Autor: Timothy T. Curran, Ji Zhang, Daniel Belmont, Koushik Das Sarma, James G. Davidson

Publikováno v: The Journal of organic chemistry. 70(15)

Lewis acid catalyzed addition of active methylene compounds to mucochloric acid (1) and mucobromic acid (2) affording Knoevenagel aldol adducts, gamma-substituted gamma-butenolides, has been explored. Catalytic efficiencies of various Lewis acids hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35576598b96892ca9cb858e35b539282
https://pubmed.ncbi.nlm.nih.gov/16018682

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Reinvestigation of Mucohalic Acids, Versatile and Useful Building Blocks for Highly Functionalized α,β-Unsaturated γ-Butyrolactones

Autor: Daniel Belmont, Peter G. Blazecka, Ji Zhang, James G. Davidson

Publikováno v: ChemInform. 34

[reaction: see text] Mucohalic acids (mucochloric acid (1, 3,4-dichloro-5-hydroxy-5H-furan-2-one) and mucobromic acid (2, 3,4-dibromo-5-hydroxy-5H-furan-2-one)) are inexpensive, commercially available starting materials with multiple functional group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b90714ca9c80bed586cc8c6ed53918
https://doi.org/10.1002/chin.200317096

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