Zobrazeno 1 - 10
of 56
pro vyhledávání: '"James G. Cronin"'
Autor:
M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101900- (2024)
The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients
Externí odkaz:
https://doaj.org/article/3288d1dd7df84df79eb03d5700edacb0
Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria
Autor:
Thomas J. R. Ormsby, Sian E. Owens, Matthew L. Turner, James G. Cronin, John J. Bromfield, I. Martin Sheldon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Treating cell lines with glucocorticoids offers protection against the damage caused by subsequent exposure to selected bacterial pore-forming toxins, and is dependent on the glucocorticoid receptor.
Externí odkaz:
https://doaj.org/article/37c56c1d42024598a0cbc0976eec8687
Autor:
Nicholas Jones, Julianna Blagih, Fabio Zani, April Rees, David G. Hill, Benjamin J. Jenkins, Caroline J. Bull, Diana Moreira, Azari I. M. Bantan, James G. Cronin, Daniele Avancini, Gareth W. Jones, David K. Finlay, Karen H. Vousden, Emma E. Vincent, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Myeloid cells are able to utilize a variety of monosaccharides from our diet, including fructose. Here the authors show that when monocytes are reliant on fructose as a carbon energy source they are reprogrammed towards oxidative metabolism, glutamin
Externí odkaz:
https://doaj.org/article/e704cf7cb7a0484a9ad0d96a44d08b6a
Autor:
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis. O
Externí odkaz:
https://doaj.org/article/142f04d5f4314de7ab090c03825dae45
Autor:
Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.
Externí odkaz:
https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
Autor:
Megan Chambers, April Rees, James G. Cronin, Manju Nair, Nicholas Jones, Catherine A. Thornton
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning
Externí odkaz:
https://doaj.org/article/e07fc9a780dc474e81eb9343a9d5d7a7
Autor:
Nicholas Jones, James G. Cronin, Garry Dolton, Silvia Panetti, Andrea J. Schauenburg, Sarah A. E. Galloway, Andrew K. Sewell, David K. Cole, Catherine A. Thornton, Nigel J. Francis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the
Externí odkaz:
https://doaj.org/article/4e275e64803946f49058ddf4bb81a441
Autor:
Luisa C. Carneiro, Carmen Bedford, Sarah Jacca, Alfonso Rosamilia, Vera F. de Lima, Gaetano Donofrio, I. Martin Sheldon, James G. Cronin
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Bovine herpesvirus-4 (BoHV-4) and bovine viral diarrhea virus (BVDV) infect the uterus of cattle, often resulting in reduced fertility, or abortion of the fetus, respectively. Here, exposure of primary bovine endometrial cells to BoHV-4 or BVDV modul
Externí odkaz:
https://doaj.org/article/4850b77eca5543159a6aa11e60c3bcde
Autor:
Benjamin J. Jenkins, Julianna Blagih, Fernando M. Ponce-Garcia, Mary Canavan, Nancy Gudgeon, Simon Eastham, David Hill, Megan M. Hanlon, Eric H. Ma, Emma L. Bishop, April Rees, James G. Cronin, Elizabeth C. Jury, Sarah K. Dimeloe, Douglas J. Veale, Catherine A. Thornton, Karen H. Vousden, David K. Finlay, Ursula Fearon, Gareth W. Jones, Linda V. Sinclair, Emma E. Vincent, Nicholas Jones
Publikováno v:
Cell Metabolism.
Autor:
April Rees, Oliver Richards, Megan Chambers, Benjamin J Jenkins, James G Cronin, Catherine A Thornton
Publikováno v:
Clinical and Experimental Immunology. 208:132-146
Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunome