Zobrazeno 1 - 10
of 20
pro vyhledávání: '"James G. Bilsland"'
Autor:
Christine Haldon, Janine Cumberbatch, Alan Wheeldon, Kevin R. Oliver, Fraser Murray, George McAllister, James G. Bilsland, Julie Goddard, Ignacio Munoz-Sanjuan
Publikováno v:
Journal of Neuroscience Methods. 157:54-63
Neural stem cells reside in the subventricular zone and the dentate gyrus of the hippocampus in adult mammalian brain. In the hippocampus, a number of factors are reported to modulate the rate of neural progenitor proliferation in the hippocampus, su
Autor:
Charlotte Dale, George McAllister, Robert P. Heavens, James G. Bilsland, Donna McLaren, Matthew Thakur, Paul C. Guest, Timothy P. Bonnert, Ignacio Munoz-Sanjuan
Publikováno v:
European Journal of Neuroscience. 24:661-675
Adult mouse subventricular zone (SVZ) neural progenitor cells (NPCs) retain the capacity to generate multiple lineages in vitro and in vivo. Thus far, the mechanisms involved in the regulation of these cells have not been well elucidated. We have car
Autor:
Marjorie S. Minkoff, James G. Bilsland, Paul C. Guest, Kamran Salim, Ignacio Munoz-Sanjuan, Laura Kehoe
Publikováno v:
Stem Cells and Development. 15:461-470
The use of neural precursor cells (NPCs) represents a promising repair strategy for many neurological disorders. This requires an understanding of the molecular events and biological features that regulate the self-renewal of NPCs and their different
Autor:
Scott J. Pollack, L Young, Sarah J. Harper, Franz Hefti, James G. Bilsland, Neil Wilkie, Peter B. Wingrove, Semantha Ellis
Publikováno v:
Journal of Neurochemistry. 78:1135-1145
Neurotrophin binding to the extracellular surface of the Trk family of tyrosine kinase receptors leads to the activation of multiple signalling cascades, culminating in neuroregenerative effects, including neuronal survival and neurite outgrowth. Sin
Publikováno v:
Journal of Neuroscience Methods. 92:75-85
Neurite outgrowth from dorsal root ganglion (DRG) explants is a method of evaluating neurotrophic activity of growth factors and neurotrophin mimetics. The drawbacks to this approach are the difficulties in quantifying the response. Neurite counts ar
Autor:
Ruth O'Donnell, Raymond G. Hill, James G. Bilsland, Christopher John Swain, Smith David W, Desmond O'Connor, Sarah J. Harper, Michael Rigby, Susan Boyce, Franz Hefti, D Evans, Louise Hewson, L Young, G Mason, L. Bristow, Brian John Williams
Publikováno v:
Neuroscience. 88:257-267
The putative neurotrophic effects of the immunophilin ligand GPI-1046 were evaluated in established experimental systems of neuron survival and axon growth in vitro and in vivo. GPI-1046 marginally increased neurite outgrowth of chick dorsal root gan
Autor:
Robert P. Heavens, Ignacio Munoz-Sanjuan, Paul J. Whiting, Timothy P. Bonnert, Alan Wheeldon, Andrew Mead, Matthew Thakur, Petr Znamenskiy, George McAllister, Kerry A. Waters, Vahri Beaumont, James G. Bilsland, Sarah Almond
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 33(3)
The receptor tyrosine kinase product of the anaplastic lymphoma kinase (ALK) gene has been implicated in oncogenesis as a product of several chromosomal translocations, although its endogeneous role in the hematopoietic and neural systems has remaine
Autor:
Heather A. Skynner, Paul C. Guest, Kamran Salim, George McAllister, Ignacio Munoz-Sanjuan, James G. Bilsland, Timothy P. Bonnert
Publikováno v:
Stem cells and development. 16(1)
The use of neural precursor cells (NPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features that control NPC proliferation and their differentiation into neurons, astrocytes,
Autor:
Sarah J. Harper, James G. Bilsland
Publikováno v:
Neuroreport. 14(7)
CEP-1347 inhibits the signalling pathway of c-jun-N-terminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth; NGF withdrawal results in apoptot
Autor:
Sophie Roy, Franz Hefti, Steve Xanthoudakis, Sarah J. Harper, Yongxin Han, Donald W. Nicholson, James G. Bilsland, Erich L. Grimm
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7)
Parkinson's disease is characterized by a loss of dopaminergic nigrostriatal neurons. This neuronal loss is mimicked by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). MPP+toxicity is mediated through inhibition of mitochondrial complex I, decreas