Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James G. Begley"'
Autor:
Georg Waeg, James G. Begley, Robert D. Azbill, Joe E. Springer, Robert J. Mark, Mark P. Mattson
Publikováno v:
Journal of Neurochemistry. 68:2469-2476
Traumatic injury to the spinal cord initiates a host of pathophysiological events that are secondary to the initial insult. One such event is the accumulation of free radicals that damage lipids, proteins, and nucleic acids. A major reactive product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f93d59e49663b9bc33a5d52ef73fad6
https://doi.org/10.1046/j.1471-4159.1997.68062469.x
https://doi.org/10.1046/j.1471-4159.1997.68062469.x
Autor:
James B. Hutchins, Mark P. Mattson, Annadora J. Bruce-Keller, James G. Begley, K. Hensley, D. Allan Butterfield, Dale E. Bredesen, Weiming Fu
Publikováno v:
Journal of Neurochemistry. 70:31-39
The bcl-2 protooncogene product possesses antiapoptotic properties in neuronal and nonneuronal cells. Recent data suggest that Bcl-2's potency as a survival factor hinges on its ability to suppress oxidative stress, but neither the subcellular site(s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac4661af20bb05bb29d0d4d7eaa0d8b
https://doi.org/10.1046/j.1471-4159.1998.70010031.x
https://doi.org/10.1046/j.1471-4159.1998.70010031.x
Publikováno v:
Brain Research. 807:167-176
Synapse loss in cerebral cortex and hippocampus is a prominent feature of Alzheimer's disease (AD) that is correlated with cognitive impairment. Postsynaptic regions of dendrites are subjected to particularly high levels of calcium influx and oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a3b33df89d953ec24cc9f50a639c1
https://doi.org/10.1016/s0006-8993(98)00763-x
https://doi.org/10.1016/s0006-8993(98)00763-x
Publikováno v:
Experimental Neurology. 153:35-48
Increasing evidence indicates that neurons die by apoptosis, an active form of cell death involving a relatively stereotyped series of biochemical changes that culminate in nuclear fragmentation, in many different developmental and pathophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301b9c88cc0a95e837064e5ae85243f0
https://doi.org/10.1006/exnr.1998.6863
https://doi.org/10.1006/exnr.1998.6863
Publikováno v:
Journal of Neuroscience Research. 50:522-530
Synapse loss, deposits of amyloid beta-peptide (Abeta), impaired energy metabolism, and cognitive deficits are defining features of Alzheimer's disease (AD). Estrogen replacement therapy reduces the risk of developing AD in postmenopausal women. Beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::603a75d5887e40727368c29d48363823
https://doi.org/10.1002/(sici)1097-4547(19971115)50:4<522::aid-jnr3>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19971115)50:4<522::aid-jnr3>3.0.co
Publikováno v:
Brain Research. 771:147-153
Amyloid beta-peptide (A beta) is produced by many different cell types and circulates in blood and cerebrospinal fluid in a soluble form. In Alzheimer's disease (AD), A beta forms insoluble fibrillar aggregates that accumulate in association with cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc0c700f891c81f99e203074c273de5
https://doi.org/10.1016/s0006-8993(97)00824-x
https://doi.org/10.1016/s0006-8993(97)00824-x
Autor:
Mark P. Mattson, James G. Begley
Publikováno v:
Amyloid. 3:28-40
The presence ofprothrontbin, thrombin receptors and thrombin inhibitors in the brain, together with recent evidence that thrombin can affect neuronal outgrowth and survival, suggests that thrombin signaling may be involved in neuronal plasticity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35334cab1c91589f0099d5a88810f121
https://doi.org/10.3109/13506129609014352
https://doi.org/10.3109/13506129609014352
Publikováno v:
International Journal of Hyperthermia. 11:379-388
Chemosensitization by two nitroimidazoles (NIs), metronidazole (METRO) and misonidazole (MISO), of the anti-tumour effect of alkylating agents was studied at three different temperatures: room temperature (RT), 37 and 41.5 degrees C. Three alkylating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ea6eb43bf1119d8e98d07c771557ef
https://doi.org/10.3109/02656739509022473
https://doi.org/10.3109/02656739509022473
Publikováno v:
Radiation Oncology Investigations. 3:64-71
Recently, various chemicals that attack the regulatory system for cell growth have been developed as potential antitumor agents. We have tested the effect of an inhibitor of protein kinase C (PKC) on cell proliferation and cytotoxicity together with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca8ee911023196f2092ef08294a9083
https://doi.org/10.1002/roi.2970030205
https://doi.org/10.1002/roi.2970030205
Publikováno v:
The Journal of biological chemistry. 274(11)
Telomerase is a protein-RNA enzyme complex that adds a six-base DNA sequence (TTAGGG) to the ends of chromosomes and thereby prevents their shortening. Reduced telomerase activity is associated with cell differentiation and accelerated cellular senes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50770536c5715b4bcf60797cfd051cf
https://pubmed.ncbi.nlm.nih.gov/10066788
https://pubmed.ncbi.nlm.nih.gov/10066788