Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

Autor: Alexander P. Nesmith, Megan L. McCain, Robert N. Willette, Pu Qin, Sean P. Sheehy, David J. Behm, Mackenzie A. Eagleson, Anna Grosberg, Kevin Kit Parker, John P. Ferrier, James G Falls, David Krull, Patrick H. Campbell, Erding Hu

Publikováno v: Sheehy, SP; Grosberg, A; Qin, P; Behm, DJ; Ferrier, JP; Eagleson, MA; et al.(2017). Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. EXPERIMENTAL BIOLOGY AND MEDICINE, 242(17), 1643-1656. doi: 10.1177/1535370217701006. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/81v8p0s0

In vitro studies of cardiac physiology and drug response have traditionally been performed on individual isolated cardiomyocytes or isotropic monolayers of cells that may not mimic desired physiological traits of the laminar adult myocardium. Recent

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http://www.escholarship.org/uc/item/81v8p0s0