Zobrazeno 1 - 10
of 53
pro vyhledávání: '"James G Cronin"'
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1118 (2020)
Lipids are critical for maintaining homeostasis and cellular metabolism. However, the dysregulation of lipid metabolism contributes to the pathogenesis of chronic inflammatory diseases and is a hallmark of several cancer types. Tumours exist in a mic
Externí odkaz:
https://doaj.org/article/cf497419fbdc43bbb90a0c4246ce8573
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151416 (2016)
Defences against the bacteria that usually infect the endometrium of postpartum cattle are impaired when there is metabolic energy stress, leading to endometritis and infertility. The endometrial response to bacteria depends on innate immunity, with
Externí odkaz:
https://doaj.org/article/ee9b439c6a1c4c64a268de234edd6fff
Autor:
M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101900- (2024)
The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients
Externí odkaz:
https://doaj.org/article/3288d1dd7df84df79eb03d5700edacb0
Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria
Autor:
Thomas J. R. Ormsby, Sian E. Owens, Matthew L. Turner, James G. Cronin, John J. Bromfield, I. Martin Sheldon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Treating cell lines with glucocorticoids offers protection against the damage caused by subsequent exposure to selected bacterial pore-forming toxins, and is dependent on the glucocorticoid receptor.
Externí odkaz:
https://doaj.org/article/37c56c1d42024598a0cbc0976eec8687
Autor:
Nicholas Jones, Julianna Blagih, Fabio Zani, April Rees, David G. Hill, Benjamin J. Jenkins, Caroline J. Bull, Diana Moreira, Azari I. M. Bantan, James G. Cronin, Daniele Avancini, Gareth W. Jones, David K. Finlay, Karen H. Vousden, Emma E. Vincent, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Myeloid cells are able to utilize a variety of monosaccharides from our diet, including fructose. Here the authors show that when monocytes are reliant on fructose as a carbon energy source they are reprogrammed towards oxidative metabolism, glutamin
Externí odkaz:
https://doaj.org/article/e704cf7cb7a0484a9ad0d96a44d08b6a
Autor:
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis. O
Externí odkaz:
https://doaj.org/article/142f04d5f4314de7ab090c03825dae45
Autor:
Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.
Externí odkaz:
https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
Autor:
Megan Chambers, April Rees, James G. Cronin, Manju Nair, Nicholas Jones, Catherine A. Thornton
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning
Externí odkaz:
https://doaj.org/article/e07fc9a780dc474e81eb9343a9d5d7a7
Autor:
Benjamin J. Jenkins, Julianna Blagih, Fernando M. Ponce-Garcia, Mary Canavan, Nancy Gudgeon, Simon Eastham, David Hill, Megan M. Hanlon, Eric H. Ma, Emma L. Bishop, April Rees, James G. Cronin, Elizabeth C. Jury, Sarah K. Dimeloe, Douglas J. Veale, Catherine A. Thornton, Karen H. Vousden, David K. Finlay, Ursula Fearon, Gareth W. Jones, Linda V. Sinclair, Emma E. Vincent, Nicholas Jones
Publikováno v:
Cell Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4bdbc86d08e780e4898fb46228013a
https://doi.org/10.1016/j.cmet.2023.05.001
https://doi.org/10.1016/j.cmet.2023.05.001
Autor:
April Rees, Oliver Richards, Megan Chambers, Benjamin J Jenkins, James G Cronin, Catherine A Thornton
Publikováno v:
Clinical and Experimental Immunology. 208:132-146
Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b245359ac79346b1678cd2510b227c0c
https://doi.org/10.1093/cei/uxac003
https://doi.org/10.1093/cei/uxac003