Zobrazeno 1 - 10 of 51 pro vyhledávání: '"James G, Karras"'
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Data from Inhibition of Growth and Metastasis of Human Hepatocellular Carcinoma by Antisense Oligonucleotide Targeting Signal Transducer and Activator of Transcription 3
Autor: Hong Zhang, James G. Karras, Youngsoo Kim, Zhao-You Tang, Yin-Kun Liu, Rui-Xia Sun, Sheng-Long Ye, Wen-Chang Li
Purpose: Hepatocellular carcinoma (HCC) is an aggressive malignancy and is a devastating clinical complication of chronic liver disease. Therapeutic options are limited mainly because the genetic and biochemical understanding of this disease remains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c87bca438910e76219d389df5091d48
https://doi.org/10.1158/1078-0432.c.6518362
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4
Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
Autor: Kevin C. Welch, Kathryn E. Hulse, Robert C. Kern, Julie A. Poposki, Homayon Banie, Pejman Soroosh, James G. Karras, Anju T. Peters, Stephanie Shintani Smith, Leslie C. Grammer, Joseph R. Raviv, David B. Conley, Whitney W. Stevens, Atsushi Kato, Aiko I. Klingler, Omid Akbari, Bruce K. Tan, Robert P. Schleimer, Gavin Lewis
Publikováno v: Immunity, Inflammation and Disease. 5:233-243
Background Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are released from T cells, innate lymphoid cells (ILC) are also known to produce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12fd3acaee26da21ce93c8fa1fb1f479
https://doi.org/10.1002/iid3.161
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6
Reflections on MicroRNAs in Chronic Pulmonary Disease: Looking into the miR-ror and Crystal Ball
Autor: James G. Karras, Guizhen Sun, Aimee L. Jackson, Jia Tay
Publikováno v: Inflammation & Allergy-Drug Targets. 12:88-98
Chronic respiratory diseases are a significant health problem requiring novel approaches to both complement existing therapies and provide breakthrough medicines. Recent clinical advances in understanding the behavior of inhaled oligonucleotides prov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f34c5af639373c72bd48e578938d6
https://doi.org/10.2174/1871528111312020003
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7
Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivity
Autor: Vipul Bhargava, James G. Karras, Nisheel Patel, Bowen Wang, Homayon Banie, Pejman Soroosh, Anuk Das, German R. Aleman Muench, Ishwarya Sankaranarayanan, Gavin Lewis, Matteo Cesaroni, Hadi Maazi, Omid Akbari, Takahiro Sato
Publikováno v: The Journal of allergy and clinical immunology. 141(3)
Background Allergic asthma is a prevalent inflammatory disease of the airways caused by dysregulated immune balance in the lungs with incompletely understood pathogenesis. The recently identified type 2 innate lymphoid cells (ILC2s) play significant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d763abe36fe4225f3e9c4999a525d7a
https://pubmed.ncbi.nlm.nih.gov/28579374
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8
Transcription Factor Signal Transducer and Activator of Transcription 5 Promotes Growth of Human Prostate Cancer Cells In vivo
Autor: Marja T. Nevalainen, James G. Karras, Benjamin E. Leiby, Robert A. Kirken, Ayush Dagvadorj
Publikováno v: Clinical Cancer Research. 14:1317-1324
Purpose: Signal transducer and activator of transcription 5a/b (Stat5a/b) is the key mediator of prolactin effects in prostate cancer cells via activation of Janus-activated kinase 2. Prolactin is a locally produced growth factor in human prostate ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6887544af27114deb23e5a1cdf9616
https://doi.org/10.1158/1078-0432.ccr-07-2024
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Autocrine Prolactin Promotes Prostate Cancer Cell Growth via Janus Kinase-2-Signal Transducer and Activator of Transcription-5a/b Signaling Pathway
Autor: Sean P. Collins, Jean-Baptiste Jomain, Hongzhen Li, James G. Karras, Junaid Abdulghani, Marja T. Nevalainen, Kalle Alanen, Vincent Goffin, Tapio Visakorpi, Tuomas Mirtti, Ayush Dagvadorj, Tobias Zellweger, Lukas Bubendorf, Martti Nurmi
Publikováno v: Endocrinology. 148:3089-3101
The molecular mechanisms that promote progression of localized prostate cancer to hormone-refractory and disseminated disease are poorly understood. Prolactin (Prl) is a local growth factor produced in high-grade prostate cancer, and exogenously adde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1caa8948b9c9fcf36387f818d02a39
https://doi.org/10.1210/en.2006-1761
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10
Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice
Autor: Cathie York-Defalco, Brianna Bender, Mausumee Guha, Doreen A. Miller, Jeffrey R. Crosby, Susan Gregory, Thomas P. Condon, Brett P. Monia, Richard S. Geary, James G. Karras, David Tung
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 321:938-946
The B7-family molecule CD86, expressed on the surface of pulmonary and thoracic lymph node antigen-presenting cells, delivers essential costimulatory signals for T-cell activation in response to inhaled allergens. CD86-CD28 signaling is involved in p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aad10384ad1c791cf1bb7af37aaad8
https://doi.org/10.1124/jpet.106.119214
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