Zobrazeno 1 - 5
of 5
pro vyhledávání: '"James Federico"'
Autor:
W. Scott Hopkins, Evan Shepherdson, Mitch Verbuyst, Chang Liu, John S. Janiszewski, Daniel W. Kung, Justin G. Stroh, James Federico, Christian Ieritano, Hui Zhang, Jefry E. Shields, Luke Melo, Bradley B. Schneider, J. C. Yves Le Blanc, J. Larry Campbell, Moaraj Hasan, Dalia Naser, Gregory W. Kauffman
Publikováno v:
ACS Central Science
ACS Central Science, Vol 3, Iss 2, Pp 101-109 (2017)
ACS Central Science, Vol 3, Iss 2, Pp 101-109 (2017)
The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4461395c33bc77be1520a814cb315b6
http://europepmc.org/articles/PMC5324087
http://europepmc.org/articles/PMC5324087
Autor:
Kuang Tongtao, Wang Zhibo, Yuanqiang Long, Jian Li, Xin Ran, Jinshan Chen, David W. Piotrowski, Hua Yi, Cristiano Ruch Werneck Guimarães, Chonggang Liu, Frank Rong, Shai Li, Heather N. Frost, Guoyun Bai, Junwei Shen, Jieyang Tan, James Federico, Hua Yu, Kexin Xu, Li Chen, Liu Bo, Ai Chaowu, Yingfu Li, Chen Yuanwei, Zhilong Jiang, Geng Xi, Hongyun Qiao, Carrie Whitney-Pickett, Magee Thomas Victor, Bo Shan, Kai Wu, Matthew D. Troutman, Mark C. Noe, Dale Gordon Mcleod, Youpei Chen, Jing Du, Gilles H. Goetz, Dapeng Zhao, Qiu Gao, Li Xiaoyong, Changqing Shi
Publikováno v:
Tetrahedron Letters. 54:3298-3301
We report novel syntheses of 12-membered macrocyclic templates and a library of 4000 macrocyclic analogs. The key macrocyclization step was performed at up to 100 g scale without resorting to syringe pumps, flow reactors or large volumes of solvent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e188654e519db141ac2ddc51f9b94f
https://doi.org/10.1016/j.tetlet.2013.04.058
https://doi.org/10.1016/j.tetlet.2013.04.058
Autor:
Hui Zhang, Russ Smith, Caroline A. Lee, Manthena V.S. Varma, Matthew D. Troutman, Charles J. Rotter, James Federico, Theodore E. Liston, Sarah Kempshall, Katherine S. Fenner, Ralph E. Davidson, Xun Zhang, John P. Umland, Carrie Whitney-Pickett, Li Di, Bo Feng, Yurong Lai, Ayman El-Kattan, Eric L. Reyner, David F. Gebhard
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4974-4985
Permeability is an important property of drug candidates. The Madin-Darby canine kidney cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK cells is the presence of endogenous transporters of nonhuman origin. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3a981abdfe2a87c8847b6b6db20f3f
https://doi.org/10.1002/jps.22674
https://doi.org/10.1002/jps.22674
Autor:
Matthew D. Troutman, John P. Umland, Mary Piotrowski, Veronica Zelesky, Kevin M. Whalen, Jason Gobey, James Federico, Hui Zhang, Theodore E. Liston, Brendon Kapinos, Carrie Funk, Walter Mitchell, Mike West, John S. Janiszewski, Richard P. Schneider
Publikováno v:
Bioanalysis. 4(9)
Background: The number of new chemical entities and types of in vitro and in vivo samples that require bioanalysis in drug discovery is large and diverse. In addition, method development time is limited as data turnaround is the highest priority. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad215c10e3a3f0414bf30a8269041480
https://pubmed.ncbi.nlm.nih.gov/22612685
https://pubmed.ncbi.nlm.nih.gov/22612685
Autor:
Mark J. Cole, John P. Umland, Matt D. Troutman, Mike West, Veronica Zelesky, Kevin M. Whalen, Cornelis E.C.A. Hop, Kelly Jenkins, Suzanne Krueger, John R. Soglia, Walter Mitchell, Stefan J. Steyn, Theodore E. Liston, Ralph E. Davidson, John S. Janiszewski, James Federico, Rebecca Lebowitz, David B. Duignan, Mark Snyder, Sabrina X. Zhao, Christine Taylor
Publikováno v:
Current drug metabolism. 9(9)
Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery and development and several reliable in vitro ADME models are available. Recently higher throughput in vitro ADME screening facilities h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf04fdfcf299c68d4bb5442bcd49710a
https://pubmed.ncbi.nlm.nih.gov/18991580
https://pubmed.ncbi.nlm.nih.gov/18991580