Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James Faeder"'
Autor:
Robin Schmucker, Gabriele Farina, James Faeder, Fabian Fröhlich, Ali Sinan Saglam, Tuomas Sandholm
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009689 (2021)
The design of efficient combination therapies is a difficult key challenge in the treatment of complex diseases such as cancers. The large heterogeneity of cancers and the large number of available drugs renders exhaustive in vivo or even in vitro in
Externí odkaz:
https://doaj.org/article/c89445c6309146cd8335d42850a913e4
Autor:
James Faeder, Robert P Sheehan, William F Hawse, Matthew J Gable, Robin E C Lee, Penelope A Morel
Publikováno v:
The Journal of Immunology. 198:150.19-150.19
Antigen stimulation of the T cell receptor in a naïve cell triggers a complex network of signaling pathways that collectively determine whether it adopts a tolerogenic, Treg, or immunogenic, Th, phenotype. The complexity of this network presents a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da7f6d6a8b461058b268aebbc960b3d
https://doi.org/10.4049/jimmunol.198.supp.150.19
https://doi.org/10.4049/jimmunol.198.supp.150.19
Publikováno v:
The Journal of Immunology. 194:49.2-49.2
IL-17 is a pro-inflammatory cytokine that promotes autoimmunity and protects against certain pathogens. Here, we present a computational model of signaling downstream of the IL-17 receptor. To manage the complexity of the system we use a rule-based m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1055a37fe5542f729c58be1daaeecf9b
https://doi.org/10.4049/jimmunol.194.supp.49.2
https://doi.org/10.4049/jimmunol.194.supp.49.2
Publikováno v:
The Journal of Immunology. 194:201.15-201.15
Antigen stimulation of the T cell receptor (TCR) in a naïve T cell triggers a complex network of signaling pathways that determine whether the cell becomes a tolerogenic T regulatory (Treg) or immunogenic T helper (TH) cell. We previously developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c86c7c378d8b51092fcc8803ba19c52
https://doi.org/10.4049/jimmunol.194.supp.201.15
https://doi.org/10.4049/jimmunol.194.supp.201.15
Publikováno v:
The Journal of Immunology. 192:182.6-182.6
IL-17 is a pro-inflammatory cytokine that promotes autoimmunity and protects against certain pathogens. Here, we present a computational model of signaling downstream of the IL-17 receptor. To manage the complexity of the system we use a rule-based m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70060ccf30af0b26275824304b5aecd2
https://doi.org/10.4049/jimmunol.192.supp.182.6
https://doi.org/10.4049/jimmunol.192.supp.182.6
Publikováno v:
The Journal of Immunology. 192:63.8-63.8
Naïve CD4+ T cells differentiate into either helper (Th) or regulatory (Treg) cells following encounter with antigen. T cell fate is in part determined by signaling strength where lower TCR and AKT/mTOR signaling favors Treg differentiation and high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b1ef13cdecc24ff65968a8aeb27714
https://doi.org/10.4049/jimmunol.192.supp.63.8
https://doi.org/10.4049/jimmunol.192.supp.63.8
Publikováno v:
The Journal of Immunology. 192:63.1-63.1
We have recently published a mathematical model that demonstrates that differential activation of signaling pathways downstream of TCR by high and low concentrations of antigen can be modeled by varying the duration of antigen stimulation, which resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecb085c1679baec2c3480b704da0d7e
https://doi.org/10.4049/jimmunol.192.supp.63.1
https://doi.org/10.4049/jimmunol.192.supp.63.1
Publikováno v:
The Journal of Immunology. 184:36.52-36.52
Peripheral naïve T-cells differentiate into regulatory, helper and other effector cells in response to a cognate antigen. The relative numbers produced of each cell type are critical for immune tolerance and affect tumor and immune-related patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c372c42523850d23e8c458d13bd1196f
https://doi.org/10.4049/jimmunol.184.supp.36.52
https://doi.org/10.4049/jimmunol.184.supp.36.52
Publikováno v:
In Biophysical Journal January 2010 98(3) Supplement 1:257a-257a
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a334930a74e1fdc3587e5f25f9c406ff
http://www.scopus.com/inward/record.url?eid=2-s2.0-84872298430&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84872298430&partnerID=MN8TOARS
