Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James F. Simpson"'
Publikováno v:
Genes. 13(9)
Elucidating the actions of genetic polymorphisms associated with the risk of Alzheimer's disease (AD) may provide novel insights into underlying mechanisms. Two polymorphisms have implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::092c7813423b31c6c192e1693918a90a
https://pubmed.ncbi.nlm.nih.gov/36140776
https://pubmed.ncbi.nlm.nih.gov/36140776
An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain
Autor:
Benjamin C. Shaw, Henry C. Snider, Andrew K. Turner, Diana J. Zajac, James F. Simpson, Steven Estus
Publikováno v:
J Alzheimers Dis
Background: Genetic variants in TREM2 are strongly associated with Alzheimer’s disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described. Objective: Recognizing that alternative splice variants can resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e8ad2d84eeafaf45364ffaf5dce05
https://pubmed.ncbi.nlm.nih.gov/35527547
https://pubmed.ncbi.nlm.nih.gov/35527547
Publikováno v:
Genes
Volume 12
Issue 7
Genes, Vol 12, Iss 1008, p 1008 (2021)
Volume 12
Issue 7
Genes, Vol 12, Iss 1008, p 1008 (2021)
Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal through imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6952c6950dd495ee274143224032f9
https://pubmed.ncbi.nlm.nih.gov/34208838
https://pubmed.ncbi.nlm.nih.gov/34208838
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e33923 (2012)
The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU
Externí odkaz:
https://doaj.org/article/99ee7dac0e6d4d618827f496ed6cc3a5
Autor:
Paul K. Crane, Christopher Medway, Shobha Potluri, Joe Chiles, James F. Simpson, Shubhabrata Mukherjee, Ying Liang, Christian M. Paumi, Dianna S. Howard, Steven G. Younkin, David W. Fardo, Steven Estus, Hualin S. Xi, Manasi Malik
Publikováno v:
Human Molecular Genetics. 24:3557-3570
The CD33 single-nucleotide polymorphism (SNP) rs3865444 has been associated with the risk of Alzheimer's disease (AD). Rs3865444 is in linkage disequilibrium with rs12459419 which has been associated with efficacy of an acute myeloid leukemia (AML) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9649e260cc51681dd1e60e650d48d22b
https://doi.org/10.1093/hmg/ddv092
https://doi.org/10.1093/hmg/ddv092
Publikováno v:
Journal of Alzheimer's disease : JAD. 59(2)
Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer’s disease (AD). In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ~1.9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9abff5d0e675a7f206cbf56ec0329f
https://pubmed.ncbi.nlm.nih.gov/28655137
https://pubmed.ncbi.nlm.nih.gov/28655137
Autor:
Crisley de Camargo, Mercival R. Francisco, James F. Simpson, Luís Fábio Silveira, Paulo V. Davanço, Mariellen C. Costa, Natasha M. Laganaro, Paulo R. R. Oliveira, Roberto M. A. Azeredo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0169636 (2017)
PLoS ONE, Vol 12, Iss 1, p e0169636 (2017)
The conservation of many endangered taxa relies on hybrid identification, and when hybrids become morphologically indistinguishable from the parental species, the use of molecular markers can assign individual admixture levels. Here, we present the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ccccb6421cdbfe958db6a11b369575
http://europepmc.org/articles/PMC5215914
http://europepmc.org/articles/PMC5215914
Publikováno v:
Journal of Neurochemistry. 115:614-624
As low-density lipoprotein receptor (LDLR) contributes to cholesterol and amyloid beta homeostasis, insights into LDLR regulation may facilitate our understanding of cardiovascular disease and Alzheimer's disease. Previously, we identified LDLR isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f00d251b3683b02ffc5c70d57809005
https://doi.org/10.1111/j.1471-4159.2010.06972.x
https://doi.org/10.1111/j.1471-4159.2010.06972.x
Autor:
James F. Simpson, Mathew J. Thayer, Olga N. Ponomoreva, Robert W. Burman, Phillip A. Yates, Mitchell S. Turker
Publikováno v:
Molecular and Cellular Biology. 23:4461-4470
Mouse Aprt constructs that are highly susceptible to DNA methylation-associated inactivation in embryonal carcinoma cells were transfected into differentiated cells, where they were expressed. Construct silencing was induced by either whole-cell fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceb6ebebc3662d5419110a123430fd4
https://doi.org/10.1128/mcb.23.13.4461-4470.2003
https://doi.org/10.1128/mcb.23.13.4461-4470.2003
Autor:
C. Jeffrey Woodbury, James F. Simpson, H. Richard Koerber, John N. Burkett, Melissa Zwick, Brian M. Davis, Kathryn M. Albers
Publikováno v:
The Journal of Neuroscience. 22:4057-4065
Most, if not all, nociceptor sensory neurons are dependent on nerve growth factor (NGF) during early embryonic development. A large subpopulation of these sensory neurons loses NGF dependency between embryonic day 16 and postnatal day 14 and become r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858489d5affa1d2c72dd51626e3e4d85
https://doi.org/10.1523/jneurosci.22-10-04057.2002
https://doi.org/10.1523/jneurosci.22-10-04057.2002