Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James F. Hochadel"'
Publikováno v:
Toxic Substance Mechanisms. 18:129-137
Cadmium is a known carcinogen that often targets male reproductive tissues. In many cells cadmium induces expression of the proto-oncogenes c-myc and c-jun. Several steroid hormones can modify the effects of cadmium, including testosterone. Thus, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438a698989a04f0f463088072eb6623d
https://doi.org/10.1080/107691899229098
https://doi.org/10.1080/107691899229098
Publikováno v:
Toxicological Sciences. 45:204-211
Arsenic exposure is clearly linked to human cancer. In rodent cells, arsenic has been reported to induce aberrant gene expression, including activation of the proto-oncogene c-myc. Abnormal or altered expression of such oncogenes can be involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfe6e30604da62fb977de1052d83111
https://doi.org/10.1006/toxs.1998.2539
https://doi.org/10.1006/toxs.1998.2539
Publikováno v:
Toxicological Sciences. 45:204-211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36f861f59220b221f7434177358f5102
https://doi.org/10.1093/toxsci/45.2.204
https://doi.org/10.1093/toxsci/45.2.204
Autor:
George T. Smith, R. Rita Misra, James F. Hochadel, Michael P. Waalkes, John C. Cook, David A. Wink
Publikováno v:
Chemical Research in Toxicology. 9:326-332
Cadmium is carcinogenic in humans and rodents. Although extensive evidence indicates that the toxicity and genotoxicity of Cd is ameliorated by binding to cysteine clusters in metallothionein (MT), the factors governing Cd release at intracellular ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296f18538dc21c6152ed4ae1502f2530
https://doi.org/10.1021/tx950109y
https://doi.org/10.1021/tx950109y
Publikováno v:
Advances in experimental medicine and biology. 537
We have used a mathematical/compartmental modeling approach along with a number of rationally designed complementary in vivo and in vitro systems to investigate the effects of administration of various retinoids and/or drug combinations on normal phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88d3378063a04864a69e5f5c7760d050
https://pubmed.ncbi.nlm.nih.gov/14995044
https://pubmed.ncbi.nlm.nih.gov/14995044
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461347590
Vitamin A-related compounds (retinoids) play critical roles in cell growth and differentia-tion (Roberts and Sporn, 1984). Since unregulated cell growth and differentiation are factors associated with most types of cancer, there has been a great deal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bee672d335ceacbdb82a3bcf0cb1b1
https://doi.org/10.1007/978-1-4419-9019-8_20
https://doi.org/10.1007/978-1-4419-9019-8_20
Publikováno v:
Journal of toxicology and environmental health. 51(6)
Cadmium (Cd) is a highly toxic metal and a known carcinogen. Although the carcinogenic mechanism of action is unknown, Cd will induce transcriptional activation of c-myc and c-jun. We have previously found that the extent of Cd-induced oncogene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b31924e0ef6eb7ef1df0da1a0316413
https://pubmed.ncbi.nlm.nih.gov/9242231
https://pubmed.ncbi.nlm.nih.gov/9242231
Publikováno v:
Toxicology. 116(1-3)
Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc74df980ab1862481c1177783a92952
https://pubmed.ncbi.nlm.nih.gov/9020520
https://pubmed.ncbi.nlm.nih.gov/9020520
Autor:
James F. Hochadel, M.P. Waalkes
Publikováno v:
Toxicology. 116(1-3)
Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c26c265174b61d281a0f2c038e7ebb
https://pubmed.ncbi.nlm.nih.gov/9020510
https://pubmed.ncbi.nlm.nih.gov/9020510
Publikováno v:
Toxicology and applied pharmacology. 142(1)
Previously, we found that in vivo pretreatment with progesterone markedly increased cadmium lethality in rats, apparently by enhancing cadmium-induced hepatonecrosis. Therefore, the present study was designed to investigate this phenomenon at the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab8f09da8d8ed509e0fc63e93c39562
https://pubmed.ncbi.nlm.nih.gov/9007047
https://pubmed.ncbi.nlm.nih.gov/9007047