Výsledky vyhledávání - "James F. Downing"

Nonimmune Phagocytosis of Liposomes by Rat Alveolar Macrophages Is Enhanced by Vitronectin and Is Vitronectin-receptor Mediated

Autor: James F. Downing, William J. Martin, Gena L. Daugherty, Paul Wisniowski, Douglas G. Perry

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 17:462-470

Pulmonary alveolar macrophages (AMs) engulf diverse materials. The mechanisms allowing AMs to recognize, bind, and phagocytose these materials are poorly understood. To test the hypothesis that the adhesive glycoprotein vitronectin (Vn) acts as a non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5831b43502afd2165f4f921cd5f8f885
https://doi.org/10.1165/ajrcmb.17.4.2059

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Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus

Autor: Homer L. Twigg, William J. Martin, Rajamouli Pasula, Jo Rae Wright, James F. Downing

Publikováno v: Proceedings of the National Academy of Sciences. 92:4848-4852

The incidence of tuberculosis is increasing on a global scale, in part due to its strong association with human immunodeficiency virus (HIV) infection. Attachment of Mycobacterium tuberculosis to its host cell, the alveolar macrophage (AM), is an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36631f3dc2a5358b637c1b39494354d
https://doi.org/10.1073/pnas.92.11.4848

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Fever Induced byEscherichia colior Intrahypothalamic Prostaglandin E2Enhances Interferon-γ Synthesis

Autor: R.S. Elizondo, James F. Downing, Milton W. Taylor, K.A. Wei, E. Lundgren

Publikováno v: Journal of Interferon Research. 10:425-433

We previously showed that hyperthermia induced in rhesus monkeys (Macaca mulatta) by forced passive heating "primes" the peripheral lymphocyte population for increased synthesis of interferon-gamma (IFN-gamma). It was not clear whether these data cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47ba660655256721a7f2caa33c486ae
https://doi.org/10.1089/jir.1990.10.425

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Gamma Interferon Stimulates Rat Alveolar Macrophages To Kill Pneumocystis carinii by l-Arginine- and Tumor Necrosis Factor-Dependent Mechanisms

Autor: Rajamouli Pasula, James F. Downing, Diane L. Kachel, William J. Martin

Pneumocystis carinii pneumonia remains a serious complication for immunocompromised patients. In the present study, P. carinii organisms interacted with gamma interferon (IFN-γ)-stimulated alveolar macrophages (AMs) to activate the l -arginine-depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e7afdc72ba6d9e6ef5cb94a789eaf
https://europepmc.org/articles/PMC96467/

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Surfactant protein A (SP-A) mediates attachment of Mycobacterium tuberculosis to murine alveolar macrophages

Autor: William J. Martin, Rajamouli Pasula, Jo Rae Wright, James F. Downing, Diane L. Kachel, Thomas E. Davis

Publikováno v: American journal of respiratory cell and molecular biology. 17(2)

Attachment of Mycobacterium tuberculosis organisms to alveolar macrophages (AMs) is an essential early event in primary pulmonary tuberculosis. Surfactant protein A (SP-A) is a nonimmune opsonin present in the alveolar spaces that binds carbohydrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f01d70e2a22feba7f5dcc123e3eb7f
https://pubmed.ncbi.nlm.nih.gov/9271309

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Hyperthermia in Humans Enhances Interferon-γ Synthesis and Alters the Peripheral Lymphocyte Population

Autor: R.S. Elizondo, E.B. Walker, H. Martinez-Valdez, James F. Downing, Milton W. Taylor

Publikováno v: Journal of Interferon Research. 8:143-150

Induction of hyperthermia (39 degrees C) in human volunteers by immersion in warm water (41-45 degrees C) rapidly alters the cell populations in the peripheral blood. In addition to granulocytosis, there is an alteration of the normal ratios among T-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed6d578a0b3f452651063f65951d74f
https://doi.org/10.1089/jir.1988.8.143

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The isolation of two mutants of Saccharomycescerevisiae which demonstrate increased activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase

Autor: Martin Bard, James F. Downing, Linda S. Burrows

Publikováno v: Biochemical and Biophysical Research Communications. 94:974-979

Two mutants of Saccharomyces cerevisiae have been isolated which demonstrate increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. The increased activity of this enzyme was paralleled by increases in sterol production. The mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338915e8a84e0c5717bbf544a13c5a4e
https://doi.org/10.1016/0006-291x(80)91330-3

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Genetic and biochemical aspects of yeast sterol regulation involving 3-hydroxy-3-methylglutaryl coenzyme A reductase

Autor: James F. Downing, Martin Bard

Publikováno v: Journal of general microbiology. 125(2)

Determinations of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) activity in haploid strains and diploid hybrids of wild-type Saccharomyces cerevisiae revealed that a genetic basis exists for control of this key regulatory enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e903f06de3a99b761fc596f65b5c380f
https://pubmed.ncbi.nlm.nih.gov/7033470

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