Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

Autor: Nikunjkumar Patel, James F. Clarke, Farzaneh Salem, Tariq Abdulla, Frederico Martins, Sumit Arora, Eleftheria Tsakalozou, Arran Hodgkinson, Omid Arjmandi‐Tash, Sinziana Cristea, Priyanka Ghosh, Khondoker Alam, Sam G. Raney, Masoud Jamei, Sebastian Polak

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1060-1084 (2022)

Abstract Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and tria

Externí odkaz: https://doaj.org/article/afd2ab177bf7434a8488d0d0e8d82e93

Dermal Absorption of Pesticide Residues

Autor: Neil Morgan, Peter K. Knowles, Sarah F. Cordery, Richard H. Guy, James F. Clarke

Publikováno v: Clarke, J, Cordery, S, Morgan, N A, Knowles, P & Guy, R 2018, ' Dermal Absorption of Pesticide Residues ', Chemical Research in Toxicology, vol. 31, no. 12, pp. 1356-1363 . https://doi.org/10.1021/acs.chemrestox.8b00227

Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfacca08beff36f251876dac55dc809a
https://pubmed.ncbi.nlm.nih.gov/30468381

In Vitro Method to Quantify Dermal Absorption of Pesticide Residues

Autor: Peter K. Knowles, Sarah F. Cordery, Richard H. Guy, Neil Morgan, James F. Clarke

Publikováno v: Clarke, J F, Cordery, S F, Morgan, N A, Knowles, P K & Guy, R H 2015, ' In vitro method to quantify dermal absorption of pesticide residues ', Chemical Research in Toxicology, vol. 28, no. 2, pp. 166-168 . https://doi.org/10.1021/tx500509z

All pesticides must go through a rigorous risk assessment process in order to show that they are safe for use. With respect to dermal risk assessment for re-entry workers, the absorption value applied to predict systemic dose from this external expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9442b584eb5bd9c93589e1b730ca4443
https://pubmed.ncbi.nlm.nih.gov/25647690

Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis

Autor: K. A. Jane White, Katherine Mary Elizabeth Turner, James F. Clarke

Publikováno v: Computational and Mathematical Methods in Medicine, Vol 2012 (2012)
Computational and Mathematical Methods in Medicine

Chlamydia has a significant impact on public health provision in the developed world. Using pair approximation equations we investigate the efficacy of control programmes for chlamydia on short time scales that are relevant to policy makers. We use o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdbc60c09102ddd62e19e7350d111c2

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

Autor: James F. Clarke, Geoffrey D. Holman, Masato Kasuga, Paul Young, K Yonezawa

Publikováno v: Europe PubMed Central

Wortmannin is a potent and reversible inhibitor of insulin-stimulated PtdIns 3-kinase activity in 3T3-L1 cells (IC50 = 2.6 +/- 0.8 nM). Wortmannin inhibits the PtdIns 3-kinase activity which is precipitated with antibodies against insulin receptor su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6831a82a1affef7c53d5a3e84a538052
https://pubmed.ncbi.nlm.nih.gov/8010944