Zobrazeno 1 - 10
of 137
pro vyhledávání: '"James F Nelson"'
Autor:
Rita A Busuttil, Ana Maria Garcia, Robert L Reddick, Martijn E T Dollé, Robert B Calder, James F Nelson, Jan Vijg
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e876 (2007)
Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain. Here it is shown that in the sma
Externí odkaz:
https://doaj.org/article/72852a56fe6548478675ba0b26ae0e09
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02db579ef847b228408c9932188dc8ee
https://doi.org/10.1111/acel.13891
https://doi.org/10.1111/acel.13891
Autor:
Martin A. Javors, Randy Strong, Gene Hubbard, James F. Nelson, Jonathan Gelfond, Elizabeth Fernandez, James D. Lechleiter, Yuji Ikeno, Veronica Galvan, Adam B. Salmon, Marisa Lopez-Cruzan, Nicolas Musi, Brett C. Ginsburg, Peter J. Hornsby
Publikováno v:
GeroScience
With evolving cores, enrichment and training programs, and supported research projects, the San Antonio (SA) Nathan Shock Center has for 26 years provided critical support to investigators locally, nationally, and abroad. With its existing and growin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ae7cc7323a24a7a800261a1d642854
https://doi.org/10.1007/s11357-021-00417-y
https://doi.org/10.1007/s11357-021-00417-y
Autor:
Randy Strong, Richard A. Miller, Catherine J. Cheng, James F. Nelson, Jonathan Gelfond, Shailaja Kesaraju Allani, Vivian Diaz, Angela Olsen Dorigatti, Jonathan Dorigatti, Elizabeth Fernandez, Andrzej Galecki, Brett Ginsburg, Karyn L. Hamilton, Martin A. Javors, Kerry Kornfeld, Matt Kaeberlein, Suja Kumar, David B. Lombard, Marisa Lopez‐Cruzan, Benjamin F. Miller, Peter Rabinovitch, Peter Reifsnyder, Nadia A. Rosenthal, Molly A. Bogue, Adam B. Salmon, Yousin Suh, Eric Verdin, Herbert Weissbach, John Newman, Francesca Maccchiarini, David E. Harrison
Publikováno v:
Aging Cell. 21
Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2-activating botanical mixture PB125, sulindac, syringaresinol, or the combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0221e182f811a34962b045ce59ef5ff
https://doi.org/10.1111/acel.13724
https://doi.org/10.1111/acel.13724
Autor:
Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo V. G. von Alvensleben, Hao Li, Saunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltán Kutalik, Robert W. Williams, Johan Auwerx
Publikováno v:
Science
DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf6f9f0aa8ed26a4fed3b1596b8a035
https://pubmed.ncbi.nlm.nih.gov/36173862
https://pubmed.ncbi.nlm.nih.gov/36173862
Publikováno v:
Cancer Research. 81:PS16-18
Previous studies have shown an altered physiology in the mammary gland of aged mice, with mammary ducts displaying increased tertiary branching along with an enriched myoepithelial population compared to younger mice. It is the population of myoepith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b6162db5493dd71eeabeddfcdf40b84
https://doi.org/10.1158/1538-7445.sabcs20-ps16-18
https://doi.org/10.1158/1538-7445.sabcs20-ps16-18
Autor:
David E. Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, Marisa Lopez‐Cruzan, Francesca Macchiarini, James F. Nelson, Adrian Markewych, Alessandro Bitto, Amy L. Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M. Stearns, Molly Bogue, Richard A. Miller
Publikováno v:
Aging Cell
Aging cell, vol 20, iss 5
Aging cell, vol 20, iss 5
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p
Interventions that increase lifespan when started late in life ar
Interventions that increase lifespan when started late in life ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf94adc8c75dde5d51c892a05d8b4fd4
https://doi.org/10.1111/acel.13328
https://doi.org/10.1111/acel.13328
Autor:
Richard A. Miller, Randy Strong, David B. Lombard, Nadia Rosenthal, Andrzej T. Galecki, Peter Reifsnyder, Warren C. Ladiges, Jessica M. Snyder, Hashan Jayarathne, David B. Allison, Martin A. Javors, Molly A. Bogue, Daniel L. Smith, Adam B. Salmon, James F. Nelson, Vivian Diaz, Navasuja Kumar, David E. Harrison, Marianna Sadagurski, W. Timothy Garvey, Elizabeth Fernandez, Lucas Kniess Debarba, Francesca Macchiarini
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 21 (2020)
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2191fa28ae373d62729c8a065248b02
https://doi.org/10.1172/jci.insight.140019
https://doi.org/10.1172/jci.insight.140019
Autor:
Michael P. Murphy, James F. Nelson, Elizabeth Fernandez, Arlan Richardson, David E. Harrison, Richard A. Miller, Peter Reifsnyder, Molly A. Bogue, Adam B. Salmon, Martin A. Javors, Nicolas Musi, Randy Strong, Michael Petrascheck, Paul Anthony Marinez, Francesca Macchiarini, Sergiy Libert
Publikováno v:
Aging Cell
To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a145f8d32332c4725861873ee0e65426
https://doi.org/10.1111/acel.13269
https://doi.org/10.1111/acel.13269
Publikováno v:
SysCon
Cloud computing is now a global standard computing topology and has been widely studied for many years. Less frequently researched is the use of cloud and edge computing to optimize the performance of a system as a whole. One important aspect of clou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4330440368e0f65dfcdabcbd6cbf647
https://doi.org/10.1109/syscon47679.2020.9275876
https://doi.org/10.1109/syscon47679.2020.9275876