Zobrazeno 1 - 10
of 264
pro vyhledávání: '"James F Collins"'
Autor:
Shireen R L Flores, Savannah Nelson, Regina R Woloshun, Xiaoyu Wang, Jung-Heun Ha, Jennifer K Lee, Yang Yu, Didier Merlin, James F Collins
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252998 (2021)
Mucosal damage, barrier breach, inflammation, and iron-deficiency anemia (IDA) typify ulcerative colitis (UC) in humans. The anemia in UC appears to mainly relate to systemic inflammation. The pathogenesis of this 'anemia of inflammation' (AI) involv
Externí odkaz:
https://doaj.org/article/78c453d90d8a4521a1ae494b657fcdaa
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161033 (2016)
Iron-copper interactions were described decades ago; however, molecular mechanisms linking the two essential minerals remain largely undefined. Investigations in humans and other mammals noted that copper levels increase in the intestinal mucosa, liv
Externí odkaz:
https://doaj.org/article/dd39fbfb17774ce8ae49c7b84ab7aaee
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Beiging of adipocytes is characteristic of a higher number of mitochondria, the central hub of metabolism in the cell. However, studies show that beiging can improve metabolic health or cause metabolic disorders. Here we discuss a liver-fat crosstalk
Externí odkaz:
https://doaj.org/article/d03c361b368b4e0ab349e0d0c20093fb
Autor:
Rola S. Zeidan, Matthew Martenson, Javier A. Tamargo, Christian McLaren, Armin Ezzati, Yi Lin, Jae Jeong Yang, Hyung-Suk Yoon, Taylor McElroy, James F. Collins, Christiaan Leeuwenburgh, Robert T. Mankowski, Stephen Anton
Publikováno v:
The Journal of Nutrition, Health and Aging, Vol 28, Iss 5, Pp 100212- (2024)
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: heme (animal
Externí odkaz:
https://doaj.org/article/33c5bf35444d462e9545a32d04a2ef45
Autor:
Sukru Gulec, James F Collins
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66010 (2013)
During iron deficiency, perturbations in copper homeostasis have frequently been documented. Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; At
Externí odkaz:
https://doaj.org/article/35f9cf1b0d2045119a24795d1f192526
Autor:
Anusree Sasidharan, Breman Anil Peethambar, Keerthi Santhosh Kumar, Ashok V. Kumar, Arun Hiregange, Neil Fawkes, James F. Collins, Astrid Grosche, Sadasivan Vidyasagar
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Assessing gastrointestinal motility lacks simultaneous evaluation of intraluminal pressure (ILP), circular muscle (CM) and longitudinal muscle (LM) contraction, and lumen emptying. In this study, a sophisticated machine was developed that sy
Externí odkaz:
https://doaj.org/article/25cae9c107664f3b995093b4aaa2006d
Autor:
Limin Shi, Zhipeng Tao, Louise Zheng, Jinying Yang, Xinran Hu, Karen Scott, Annette de Kloet, Eric Krause, James F. Collins, Zhiyong Cheng
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102727- (2023)
Adipose plasticity is critical for metabolic homeostasis. Adipocyte transdifferentiation plays an important role in adipose plasticity, but the molecular mechanism of transdifferentiation remains incompletely understood. Here we show that the transcr
Externí odkaz:
https://doaj.org/article/10f9fe35ce0e40119021cc7ce0f0f995
Autor:
Limin Shi, Zhipeng Tao, Louise Zheng, Jinying Yang, Xinran Hu, Karen Scott, Annette de Kloet, Eric Krause, James F. Collins, Zhiyong Cheng
Adipose plasticity is critical for metabolic homeostasis. Adipocyte transdifferentiation plays an important role in adipose plasticity, but the molecular mechanism of transdifferentiation remains incompletely understood. Here we show that the transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49eee15c570de25ee79f43d1abffdd4
https://hdl.handle.net/10919/115606
https://hdl.handle.net/10919/115606
Autor:
Yang Yu, Regina R Woloshun, Jennifer K Lee, Pearl Onuwa Ebea, Sean Zhu, Elizabeta Nemeth, Laura Garrick, Michael Garrick, James F. Collins
Publikováno v:
Blood Journal.
Pregnancy rates in β-thalassemia are increasing, but the risk of complications is higher; thus, better understanding of maternal and fetal iron homeostasis in this disorder is needed. HbbTh3/+ (Th3/+) mice model human β-thalassemia. Both the murine
Autor:
Xiaoyu Wang, Mingzhen Zhang, Regina R. Woloshun, Yang Yu, Jennifer K. Lee, Shireen R. L. Flores, Didier Merlin, James F. Collins
Publikováno v:
Nutrients, Vol 13, Iss 5, p 1686 (2021)
Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. In the genetic, iron-loading
Externí odkaz:
https://doaj.org/article/594c0d3fb7ad4b39895a34a2de5d7635