Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James F, Truax"'
Autor:
Amber B. Daniel, John P. Rooney, David Allen, Patricia Ceger, James F. Truax, Nicole Kleinstreuer, Neepa Choksi
Publikováno v:
Regul Toxicol Pharmacol
The in vivo rabbit test is the benchmark against which new approach methodologies for skin irritation are usually compared. No alternative method offers a complete replacement of animal use for this endpoint for all regulatory applications. Variabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6aaeaf10ae6bdcdfb1519bfde2713c4
https://pubmed.ncbi.nlm.nih.gov/33757807
https://pubmed.ncbi.nlm.nih.gov/33757807
Autor:
James F. Truax, J. Patrick Condreay, Jennings F. Worley, Christopher J. Apolito, T. A. Kost, Gang An, Jeffrey L. Pfohl
Publikováno v:
Receptors and Channels. 8:99-111
A variety of transfection approaches have been used to deliver plasmids encoding ion channel genes into cells. We have used the baculovirus transduction system, BacMam, to demonstrate transient expression of multi-subunit KATP channels in CHO-K1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c6c702e77a5c196eef4afb362f061f
https://doi.org/10.3109/10606820212396
https://doi.org/10.3109/10606820212396
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 61(1)
U.S. Federal Hazardous Substances Act (FHSA) regulations specify eye safety testing procedures and hazard classification criteria for substances regulated by the U.S. Consumer Product Safety Commission (CPSC). Current regulations require up to three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081b8c8532efa2914b66b6f119ac476a
https://pubmed.ncbi.nlm.nih.gov/21745525
https://pubmed.ncbi.nlm.nih.gov/21745525
Publikováno v:
Journal of Pharmacological Methods. 23:51-61
Subplantar injection of 250 μg of trypsin in the rat resulted in a biphasic increase in pain sensitivity (hyperalgesia) with peaks at 10 and 150 min separated by a period of decreased sensitivity to pain (hypoalgesia). Hyperalgesia was assessed by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857987851935d50ae366f5f4fa70720a
https://doi.org/10.1016/0160-5402(90)90008-9
https://doi.org/10.1016/0160-5402(90)90008-9
Autor:
Jeffrey L, Pfohl, Jennings F, Worley, J Patrick, Condreay, Gang, An, Christopher J, Apolito, Tom A, Kost, James F, Truax
Publikováno v:
Receptorschannels. 8(2)
A variety of transfection approaches have been used to deliver plasmids encoding ion channel genes into cells. We have used the baculovirus transduction system, BacMam, to demonstrate transient expression of multi-subunit KATP channels in CHO-K1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b4811ee8b0d6eecc559f39c18ff59a1
https://pubmed.ncbi.nlm.nih.gov/12448791
https://pubmed.ncbi.nlm.nih.gov/12448791
Autor:
Jeffrey L. Selph, Randy T. McConnell, Pedro Cuatrecasas, Ralph Vinegar, Ned A. Porter, James F. Truax, Marvin I. Siegel
Publikováno v:
Biochemical and Biophysical Research Communications. 92:688-695
Aspirin-like drugs inhibit the metabolism of arachidonic acid via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates. These non-steroidal anti-inflammatory drugs inhibit the formation of 11-hydroxy- and 15-hydroxy-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a0e3c8423b4f5576273330c568d30d
https://doi.org/10.1016/0006-291x(80)90388-5
https://doi.org/10.1016/0006-291x(80)90388-5
Publikováno v:
Journal of Medicinal Chemistry. 32:1471-1475
Azathioprine [Imuran; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine] is a widely used immunosuppressive and antiarthritic drug. For the sake of comparison, the riboside, the 2'-deoxyriboside, and the arabinoside of azathioprine and its 2-amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6624c0dc3c3465be5adcffe97b5ade57
https://doi.org/10.1021/jm00127a013
https://doi.org/10.1021/jm00127a013
Publikováno v:
Journal of Immunopharmacology. 1:497-520
Administration of azathioprine in the diet to Lewis rats reduced the lethality of this drug relative to various regimens by gavage. This mode of administration made it possible to administer effective doses with reduced toxicity. Azathioprine blocked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822f68cb789bc4e3aedc8658c62fdd89
https://doi.org/10.3109/08923977909040548
https://doi.org/10.3109/08923977909040548
Publikováno v:
European journal of pharmacology. 37(1)
The mild analgesic activities of aspirin, phenacetin and acetaminophen have been compared in the trypsin, kaolin and carrageenan hyperalgesic assays as well as in the acetic acid writhing test. The trypsin and kaolin hyperalgesic assays were designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31def77423f04af67218586859f413a2
https://pubmed.ncbi.nlm.nih.gov/1278245
https://pubmed.ncbi.nlm.nih.gov/1278245
Publikováno v:
Prostaglandins, leukotrienes, and medicine. 20(1)
Cells were harvested from rat pleural cavity before and during the inflammatory response stimulated by carrageenan injection. The conversion of [ 14 C]arachidonate by intact cells into products of the cyclooxygenase and 5-lipoxygenase pathways was st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4e9489b411d49b9e82d5d30b47754
https://pubmed.ncbi.nlm.nih.gov/3934682
https://pubmed.ncbi.nlm.nih.gov/3934682