Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James F, Tobin"'
Autor:
Dandan Shan, Jian-liang Li, Leeying Wu, Dongmei Li, Jonathan Hurov, James F. Tobin, Ruth E. Gimeno, Jingsong Cao
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1971-1981 (2010)
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report the further characterization of the two recently identified microsomal G
Externí odkaz:
https://doaj.org/article/559f449bc4eb43a0a44052aa87f8f610
Publikováno v:
PPAR Research, Vol 2008 (2008)
Externí odkaz:
https://doaj.org/article/0c6869dc8f964146803cb7bfc71191bf
Autor:
Jingsong Cao, Yingjiang Zhou, Ruth E. Gimeno, Ronald W. Clark, Mylene Perreault, James F. Tobin, Bryan Goodwin, Ariful Qadri, Haibing Peng, Sylvie Perez, Qingcong Lin
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 306:E1176-E1187
Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two closely related genes, GPAT3 and GPAT4. To investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdadd077823eade7b8b35702cf779c4
https://doi.org/10.1152/ajpendo.00666.2013
https://doi.org/10.1152/ajpendo.00666.2013
Autor:
James F. Tobin, Anthony J. Celeste
Publikováno v:
Current Opinion in Pharmacology. 5:328-332
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848bfe20de70e9a1071e6efa3ede7beb
https://doi.org/10.1016/j.coph.2005.01.011
https://doi.org/10.1016/j.coph.2005.01.011
Autor:
Se-Jin Lee, Leslie E Stolz, Thomas Braun, Thomas Riebel, Wolfgang Kömen, James F. Tobin, Christoph Hübner, Kathryn R. Wagner, Markus Schuelke
Publikováno v:
New England Journal of Medicine. 350:2682-2688
Both acquired and inherited disorders of muscle are common; thus, greater understanding of muscle growth and maintenance is important for future therapies. Myostatin down-regulates muscle growth. These investigators describe a mutation in the gene fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00956147c2148c8fa51255ed038e197f
https://doi.org/10.1056/nejmoa040933
https://doi.org/10.1056/nejmoa040933
Publikováno v:
Biochemical and Biophysical Research Communications. 298:545-551
We have cloned and characterized two novel human low molecular weight dual specificity phosphatases (LMW-DSPs). Both genes are expressed exclusively in the testis, but are not altered in any of several disease states examined. Transfection into COS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05406ea22461d849a63663c9fdcd6065
https://doi.org/10.1016/s0006-291x(02)02488-9
https://doi.org/10.1016/s0006-291x(02)02488-9
Publikováno v:
The EMBO Journal. 19:3530-3541
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 Å and the human p70 complex at 2.8 Å resolution, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a70cf3e42556db0cee20afbaf7777e5
https://doi.org/10.1093/emboj/19.14.3530
https://doi.org/10.1093/emboj/19.14.3530
Autor:
Tarek S. Mansour, Mylene Perreault, Joel Bard, Eva Chenail, Xianbin Tian, James F. Tobin, Xiangping Li, Jason Shaoyun Xiang, Zhao-Kui Wan, Xin Xu, Manus Ipek, Darrell Panza, Kristine Svenson, Huan-Qiu Li, Eddine Saiah, Ariful Qadri, Vipin Suri, Mengmeng Wang, Christian E. Johnson, Seung Hahm
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of inactive glucocorticoid cortisone to its active form, cortisol. The glucocorticoid receptor (GR) signaling pathway has been linked to the pathophysiology of diabetes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac55ea3454d8d6acc241eb07df394729
https://europepmc.org/articles/PMC4027441/
https://europepmc.org/articles/PMC4027441/
Autor:
Yingjiang Zhou, Tiffany Gareski, John C. McKew, Ruth E. Gimeno, Mengxiao Shi, Jingsong Cao, Xin Xu, Juli Jones, Haibing Peng, Shannon Stahler, Ariful Qadri, Seung Hahm, Vipin Suri, Mylene Perreault, James F. Tobin, Xinyi Huang
Publikováno v:
The Journal of biological chemistry. 286(48)
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df44a5cab57b4fc343ff4ec144ae1b9b
https://pubmed.ncbi.nlm.nih.gov/21990351
https://pubmed.ncbi.nlm.nih.gov/21990351
Autor:
James F. Tobin, Anthony J. Celeste
Publikováno v:
Drug discovery today. 11(9-10)
Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) control the development and homeostasis of multiple tissue types in many organisms, from humans to invertebrates. These morphogens are expressed in a tissue-specific manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f433cb66c48350ee0e9bc266e7737ed
https://pubmed.ncbi.nlm.nih.gov/16635802
https://pubmed.ncbi.nlm.nih.gov/16635802